Discovery and in vitro and in vivo profiles of N-ethyl-N-[2-[3-(5-fluoro-2-pyridinyl)-1H-pyrazol-1-yl]ethyl]-2-(2H-1,2,3-triazol-2-yl)-benzamide as a novel class of dual orexin receptor antagonist
Keywords: OX1, orexin 1; OX2, orexin 2; CSF, cerebrospinal fluid; POC, proof-of-concept; DORA, dual orexin receptor antagonist; REM, rapid eye movement; NREM, non-REM; HATU, N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium he