Keywords: Electron affinity; Energy of the lowest unoccupied molecular orbital; Keap1/Nrf2/ARE pathway; Nrf2 activator; NAD(P)H:quinone oxidoreductase 1 (NQO1) inducer; QSAR;
مقالات ISI (ترجمه نشده)
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Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3Ã/Fyn pathway
Keywords: Cardiomyopathy; Angiotensin II; Nrf2 activator; Oxidative stress;
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults
Keywords: Isoflavone; 7-O-methylbiochanin A; Oxidative stress; Nrf2 activator; ARE; antioxidant response element; COPD; chronic obstructive pulmonary disease; γ-GCS; γ-glutamyl cysteine synthetase; GSH; glutathione; HO-1; heme oxygenase-1; Keap1; Kelch-like ECH-a
Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells
Keywords: AO; acridine orange; ARE; antioxidant response element; As(III); sodium arsenite; CC; column chromatography; CHX; cycloheximide; COPD; chronic obstructive pulmonary disease; DAPI; 6-diamidino-2-phenylindole; EB; ethidium bromide; γ-GCS; γ-glutamylcystei
Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism
Keywords: Nrf2 activator; CDDO-Im; Carnosic acid; Neuroblastoma; Carbonyl stress; Methylglyoxal; GSH synthesis; AGEs; advanced glycation end products; AKR; aldo-keto reductase; BSO; buthionine sulfoximine; CA; carnosic acid; CEL; Nε-(1-carboxyethyl)lysine; CDDO-Im
Molecular similarity guided optimization of novel Nrf2 activators with 1,2,4-oxadiazole core
Keywords: Keap1; Kelch-like ECH-associated protein-1; Nrf2; nuclear factor erythroid 2-related factor 2; ARE; antioxidant response element; NQO1; NAD(P)H/quinone oxidoreductase; HO-1; heme oxygenase-1; γ-GCS; γ-glutamyl cysteine synthetase; VS; virtual screening;