Quantitative relationship between guanine O6-alkyl lesions produced by Onrigin™ and tumor resistance by O6-alkylguanine-DNA alkyltransferase
Keywords: AGT, O6-alkylguanine-DNA alkyltransferase; 3H-BG, [benzene-3H]O6-benzylguanine; O6-BG, O6-benzylguanine; IC50, concentration giving 50% inhibition; 90CE, 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine; 101MDCE, 1,2-bis(methylsulfonyl)-1-[(methylamino)