
Chronic treatment with the opioid antagonist naltrexone favours the coupling of spinal cord μ-opioid receptors to Gαz protein subunits
Keywords: Opioid antagonist; Opioid receptors; G-protein; Adenylyl cyclase; Constitutive activity; Inverse agonismAC, Adenylyl cyclase; DAMGO, Tyr-d-Ala-Gly-Me-Fe-Gly-ol-enkephalin; FK, Forskolin; ODN, oligodeoxyribonucleotides; PTX, Pertussis toxin