
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors
Keywords: AD; Alzheimer disease; cAMP; cyclic adenosine monophosphate; CREB; cAMP response element-binding protein; cGMP; cyclic guanosine monophosphate; OLT; object location test; ORT; object recognition test; PDE; phosphodiesterase; PDE4Is; PDE4 inhibitors; PTC;