دانلود مقالات ISI درباره Orl1 + ترجمه فارسی

تجزیه و تحلیل تنظیمات محصول طبیعی گیرنده های اپیوئیدی در درمان بیماری های انسانی

Analysis of natural product regulation of opioid receptors in the treatment of human disease

Keywords: 4HNE; 4-Hydroxy-2-nonenal; AC; Adenylyl cyclase; AD; Alzheimer's disease; AMP; Adenosine monophosphate; AMPK; AMP-activated protein kinase; cAMP; Cyclic adenosine 3′,5′-monophosphate; CB; Cannabinoid receptor; CHO; Chinese hamster ovary; DAL; Dehydro-

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids

Keywords: MOR; μ-opioid receptor; 6TM MOR; six transmembrane helices μ-opioid receptor; 7TM MOR; seven transmembrane helices μ-opioid receptor; OIH; opioid induced hyperalgesia; VGCC; voltage-gated Ca2 + channels; cAMP; cyclic adenosine monophosphate; AC; adeny

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2015 سفارش ترجمه

Design, synthesis and evaluation of [3H]PF-7191, a highly specific nociceptin opioid peptide (NOP) receptor radiotracer for in vivo receptor occupancy (RO) studies

Keywords: NOP receptor; ORL1; Radiotracer; Receptor occupancy; PET

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Pharmacogenomic study of the role of the nociceptin/orphanin FQ receptor and opioid receptors in diabetic hyperalgesia

Keywords: Antihyperalgesia; Knockout mice; Nociceptin/orphanin FQ receptor; Opioid receptors; ORL1; Neuropathic pain;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor

Keywords: Boc; butoxycarbonyl; Bmax; receptor density; DMEM; Dulbecco's Modified Eagle's Medium; DMF; N,N-dimethylformamide; FBS; fetal bovine serum; GPCR; G protein-coupled receptor; HBTU; 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Activation of membrane estrogen receptors attenuates opioid receptor-like1 receptor-mediated antinociception via an ERK-dependent non-genomic mechanism

Keywords: ANOVA; analysis of variance; AUC; area under the curve; DPN; diarylpropionitrile; E2BSA; β-estradiol-6-(O-carboxymethyl)oxime: bovine serum albumin; ERK; extracellular signal-regulated kinase; GIRK; G protein-gated inwardly rectifying potassium channels;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor

Keywords: Ac-RYYRIK-NH2; the one-letter amino acid code denotes Ac-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle's medium; DMF; N,N-dimethylformamide; EC50; the concentration for the half maximal effective concentration

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Effects of the NOP receptor agonist Ro65-6570 on the acquisition of opiate- and psychostimulant-induced conditioned place preference in rats

Keywords: Drug dependence and abuse; Nociceptin; Opiate; Behavioural pharmacology; ORL1

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis and structure–activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: Part 2

Keywords: Nociceptin; NOP; ORL1; Antitussive; Opioid

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Spare interactions of highly potent [Arg14,Lys15]nociceptin for cooperative induction of ORL1 receptor activation

Keywords: EL2; The second extracellular loop; GPCR; G protein-coupled receptor; ORL1; Opioid receptor-like receptor 1; TM5; The fifth transmembrane domain; Binding site; Nociceptin; Receptor activation; Site-directed mutagenesis; Synergistic effect;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Design, synthesis, and structure–activity relationship study of a novel class of ORL1 receptor antagonists based on N-biarylmethyl spiropiperidine

Keywords: ORL1; Antagonist; N-Biarylmethyl spiropiperidine; hERG channel

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Opioid and nociceptin receptors regulate cytokine and cytokine receptor expression

Keywords: Opioid; Opioid receptors; Chemokine; Chemokine receptors; Cytokine; Nociceptin; GPCR; HIV; ORL1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties

Keywords: NOP; ORL1; Antinociception; Analgesic; Sedative; Benzimidazolone

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2007 سفارش ترجمه

Comparison of the in vitro efficacy of μ, δ, κ and ORL1 receptor agonists and non-selective opioid agonists in dog brain membranes

Keywords: Dog; Opioid receptor; ORL1; G protein; Efficacy; [35S]GTPγS

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Distribution of nociceptin and Ro64-6198 activated [35S]-GTPγS binding in the rat brain

Keywords: Autoradiography; Receptor binding; Anxiety; Pain; Depression; ORL1; Orphanin FQ;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists

Keywords: ORL1; Nociception; Opioid; Analgesia;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Nociceptin/orphanin FQ (N/OFQ) inhibits excitatory and inhibitory synaptic signaling in the suprachiasmatic nucleus (SCN)

Keywords: circadian rhythm; synaptic transmission; excitatory postsynaptic current; inhibitory postsynaptic current; GABA; calcium channel; ACSF; artificial cerebrospinal fluid; AMPA; (RS)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APV; dl-2-amino-5-pho

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه