Keywords: Choroid plexus carcinoma; Mouse model; Myc; Trp53; Otx2; Paediatric cancer;
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Keywords: 6-OHDA; 6-hydroxydopamine; Aβ; amyloid-β; AD; Alzheimer disease; ALS; amyotrophic lateral sclerosis; APOE4; apolipoprotein E4; APP; amyloid precursor protein; ASCL1; achaete-scute family basic helix-loop-helix transcription factor 1; ATP; adenosine trip
Keywords: 2210010C04Rik; RIKEN cDNA 2210010C04 gene; 5330417C22Rik; RIKEN cDNA 5330417C22 gene; A1AT; alpha1-antitrypsin; Ago1; argonaute RISC catalytic component 1; Amy2a5; amylase 2a5; Amy2b; amylase, alpha 2B; AP1/JUN; jun proto-oncogene; Bmp; bone morphogenetic
Keywords: Inherited Retinal Dystrophies; Transcription factors; OTX2; CRX; NRL
Keywords: Homeoproteins; Cortical regionalisation; Retino-tectal; Barrel field; Otx2; Engrailed;
Keywords: Microphthalmia; Anophthalmia; Coloboma; Developmental eye defects; eye genes; Mutation; SOX2; OTX2;
Knockdown of the thyroid hormone transporter MCT8 in chicken retinal precursor cells hampers early retinal development and results in a shift towards more UV/blue cones at the expense of green/red cones
Keywords: Thyroid hormone; Monocarboxylate transporter 8; Retina; Development; Chicken embryo; RNA interference; AP; alkaline phosphatase; BRN3a; brain-specific homeobox/POU domain protein 3a; CNS; central nervous system; CRX; Cone-Rod homeobox; DAC; displaced amac
Tau Deficiency Down-Regulated Transcription Factor Orthodenticle Homeobox 2 Expression in the Dopaminergic Neurons in Ventral Tegmental Area and Caused No Obvious Motor Deficits in Mice
Keywords: mDANs; midbrain dopaminergic (DA) neurons; OTX2; Orthodenticle homeobox 2; PD; Parkinson's disease; Lmx1b; LIM homeobox transcription factors 1-beta; Pitx3; pituitary homeobox 3; Girk2; G protein-gated inwardly rectifying K+ channel; DAT; dopamine trans
Novel and functional ATG12 gene variants in sporadic Parkinson's disease
Keywords: PD; Parkinson's disease; ATG; autophagy-related gene; DSVs; DNA sequence variants; SNCA; alpha synuclein gene; LRRK2; leucine-rich repeat kinase 2; VPS35; vacuolar protein sorting 35; PINK1; PTEN-induced kinase 1; GBA; Glucocerebrosidase; CMA; chaperone-m
Comparative analysis of the neurula transcriptomes of two species of flatfishes: Platichthys stellatus and Paralichthys olivaceus
Keywords: BMP; Bone Morphogenetic Protein; BMPR; Bone Morphogenetic Protein Receptor; BLAST; Basic Local Alignment Search Tool; ERBB; Erb-b2 Receptor Tyrosine Kinase; FGF; Fibroblast Growth Factor; FGFR; Fibroblast Growth Factor Receptor; FZ; Frizzled; HOXB1B; Home
Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast
Keywords: Otx2; Nanog; pluripotency; embryonic stem cells; preimplantation epiblast
Neuroplasticity and MRI: A perfect match
Keywords: AChEI; Acetyl choline esterase inhibitor; AD; Axial diffusivity; ADC; Apparent diffusion coefficient; ASL; Arterial spin labeling; BBB; Blood-brain barrier; BDNF; Brain-derived neurotrophic factor; BrdU; Bromodeoxyuridine; BOLD; Blood-oxygenation level-
SOX2, OTX2 and PAX6 analysis in subjects with anophthalmia and microphthalmia
Keywords: Anophthalmia; Microphthalmia; SOX2; OTX2; PAX6
AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression
Keywords: Anterior-posterior axis; Anterior visceral endoderm; Otx2; Dkk1; Time-lapse imaging; Cell lineage tracing;
Stem cell profiling in head and neck cancer reveals an Oct-4 expressing subpopulation with properties of chemoresistance
Keywords: HNSCC; Head and neck cancer; Cancer stem cells; Stem cell profiling; Oct-4; Oct-4A; CD44; GATA4; Goosecoid; HNF-3ß/FoxA2; Otx2; PDX-1/IPF1; Sox17
Otx2 expression in anterior neuroectoderm and forebrain/midbrain is directed by more than six enhancers
Keywords: Otx2; Enhancer; Anterior neuroectoderm; Forebrain; Midbrain;
Increased dopaminergic innervation in the brain of conditional mutant mice overexpressing Otx2: Effects on locomotor behavior and seizure susceptibility
Keywords: 5-HT; serotonin; ANOVA; analysis of variance; DA; dopamine; Dat; dopamine transporter; EEG; electroencephalographic recordings; GAD65; glutamic acid decarboxylase 65Â kD; GCL; granule cell layer of the dentate gyrus; glyco-Dat; glycosylated active form of
Specific expression pattern of a novel Otx2 splicing variant during neural differentiation
Keywords: ORF; open reading frame; MEF; mouse embryonic fibroblast; ESC; embryonic stem cell; FBS; fetal bovine serum; eGFP; enhanced green fluorescence protein; lncRNA; long non-protein coding RNA; Otx2; Alternative splicing; Non-coding RNA; Neural differentiation
Gene dosage of Otx2 is important for fertility in male mice
Keywords: Hypothalamus; Gonadotropin-releasing hormone; Pituitary; Otx2; Homeodomain;
The homeobox gene Otx2 in development and disease
Keywords: OTX2; homeobox; DNA binding protein; forebrain; retinal development; photoreceptor;
Experience-dependent development of perineuronal nets and chondroitin sulfate proteoglycan receptors in mouse visual cortex
Keywords: CSPGs; chondroitin sulfate proteoglycans; ECM; extracellular matrix; GAG; glycosaminoglycan; GABA; γ-aminobutyric acid; HA; hyaluronan; LAR; leukocyte common antigen-related phosphatase; NgR; nogo receptor; NGS; normal goat serum; OD; ocular dominance; O
Concurrent deletion of BMP4 and OTX2 genes, two master genes in ophthalmogenesis
Keywords: BMP4; OTX2; 14q22AM, anophthalmia–microphthalmia
Agnathia-otocephaly complex: A case report and examination of the OTX2 and PRRX1 genes
Keywords: DNA; Deoxyribonucleic Acid; HSV; Herpes simplex virus; VSD; Ventricular septal defect; APGAR; Appearance, Pulse, Grimace, Activity, Respiration; NICU; Neonatal Intesive Care Unit; PCR; Polymerase Chain Reaction; HFD; Hypomandibular faciocranial dysostosis
orthodenticle/otx ortholog expression in the anterior brain and eyes of Sepia officinalis (Mollusca, Cephalopoda)
Keywords: Sepia officinalis; Development; otx2; Brain regionalization; Eyes
A lineage specific enhancer drives Otx2 expression in teleost organizer tissues
Keywords: Otx2; Head organizer; Enhancer; Teleost; Evolution; Anterior visceral endoderm; Transgenic;
Multiple origins, migratory paths and molecular profiles of cells populating the avian interpeduncular nucleus
Keywords: Interpeduncular nucleus; PAX7; Nkx6.1; Otp; Otx2; Cell migration; Isthmus; Rhombomere 1
Eye development genes and known syndromes
Keywords: Anophthalmia/Microphthalmia; SOX2; Anophthalmia-Esophageal-Genital (AEG) syndrome; OTX2;
Septo-optic dysplasia and other midline defects: The role of transcription factors: HESX1 and beyond
Keywords: Septo-optic dysplasia; pituitary; HESX1; SOX2; SOX3; OTX2
Identification of a retina-specific Otx2 enhancer element active in immature developing photoreceptors
Keywords: Retina; Development; Otx2; Specification; Photoreceptors; Enhancer element; Electroporation
Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes
Keywords: Retina; Repressor; Photoreceptor cell; Ankyrin repeat; Transcriptional cofactor; Crx; cone-rod homeobox; Otx2; orthodenticle homolog 2; Nrl; neural retina leucine zipper; Nr2e3; nuclear receptor subfamily 2 group E member 3;
Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm
Keywords: Otx2; Head organizer; Anterior visceral endoderm; Anterior mesendoderm; Cis-element; Evolution
Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons
Keywords: Locus coeruleus; Development; Mid-hindbrain organizer; Isthmic organizer; Bone morphogenetic proteins; Bmp5; Bmp7; Otx2; Noradrenaline; Hindbrain;
Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization
Keywords: Otx2; Otx1; Enhancer; Forebrain; Midbrain; Isthmus
The Pax3 and Pax7 paralogs cooperate in neural and neural crest patterning using distinct molecular mechanisms, in Xenopus laevis embryos
Keywords: Pax3; Pax7; Brain; Neural crest; Mesoderm; FGF; WNT; Otx2; Krox20; Snail2; Patterning;
Rapid adaptation of molecular resources from zebrafish and medaka to develop an estuarine/marine model
Keywords: Medaka; Zebrafish; Oryzias dancena; Oryzias melastigma; Marine model; DM1A; MF20; Islet-1; HuC/HuD; Dlx2; Otx2; Eng2; Krox-20;
Critical role of the embryonic mid-hindbrain organizer in the behavioral response to amphetamine and methylphenidate
Keywords: psychostimulants; isthmic organizer; hyperactivity; Otx2; dopamine; serotonin; AMPH; amphetamine; CPu; caudate putamen; DA; dopaminergic; DAT; dopamine transporter; EPM; elevated plus maze; FLU; fluoxetine; HPLC; high performance liquid chromatography; MH
Spatial and temporal regulation of Wnt/β-catenin signaling is essential for development of the retinal pigment epithelium
Keywords: Wnt/β-catenin signaling; Retinal pigment epithelium; Neural retina; Mitf; Otx2
Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm
Keywords: Otx2; Visceral endoderm; Head morphogenesis; A–P axis conversion; Gastrulation; Forebrain; Midbrain; Dkk1; Lefty1
Elucidating the phenomenon of HESC-derived RPE: Anatomy of cell genesis, expansion and retinal transplantation
Keywords: Age-related macular degeneration; Human embryonic stem cells; Retinal Pigment Epithelium; OTX2; Pax6; PMEL17; Cytokeratin 8; RPE65; RCS dystrophic rat; Phagocytosis
Emerging restorative treatments for Parkinson's disease
Keywords: Ad; adenovirus; AAV; adeno-associated virus; BBB; blood-brain barrier; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; CD45; cluster of differentiation 45; CNTF; ciliary neurotrophic factor; CSF; cerebrospinal fluid; DAT;
Ontogenetic expression of the Otx2 and Crx homeobox genes in the retina of the rat
Keywords: Otx2; Crx; homeobox; retina; development; ratAANAT, arylalkylamine N-acetyltransferase; Crx, cone–rod homeobox; GCL, ganglion cell layer; HIOMT, hydroxyindole-O-methyltransferase; INL, inner nuclear layer; IPL, inner plexiform layer; NR, neural retina; ON
Molecular mechanisms underlying inner ear patterning defects in kreisler mutants
Keywords: Inner ear; Kreisler; MafB; Endolymphatic sac; Wnt2b; Otx2; Dlx5; Gbx2; Mouse
Melatoninergic differentiation of retinal photoreceptors: Activation of the chicken hydroxyindole-O-methyltransferase promoter requires a homeodomain-binding element that interacts with Otx2
Keywords: photoreceptor; melatonin; hydroxyindole-O-methyltransferase; Otx2; transcriptional regulation; chicken; retina; pineal
The chick/quail transplantation model: Discovery of the isthmic organizer center
Keywords: Development and regeneration; Pattern, formation, compartment and boundaries; Chick/quail chimeras; Otx2; Gbx2; Fgf8; En2; Isthmic organizer; MHB; Mes/metencephalon;
Functional analysis of transcriptional repressor Otx3/Dmbx1
Keywords: HD, homeodomain; Gal4dbd, Gal4 DNA binding domain; aa, amino acid; GST, glutathione S-transferase; EMSA, electrophoretic mobility shift assay; tk, thymidine kinase; dpc, days postcoitumHeterodimerization; Otx2; Otx3/Dmbx1
Antagonistic interaction between IGF and Wnt/JNK signaling in convergent extension in Xenopus embryo
Keywords: Wnt; IGF; JNK; Otx2; Xbra; Xenopus; Gastrulation; Convergent extension; Morphogenetic movements;
chokh/rx3 specifies the retinal pigment epithelium fate independently of eye morphogenesis
Keywords: RPE development; rx3; Eye development; Gene duplication; Morphogenesis; otx2; Robustness; Zebrafish; Genetics; Selector gene;
Comparative analysis of gnathostome Otx gene expression patterns in the developing eye: implications for the functional evolution of the multigene family
Keywords: Otx1; Otx2; Otx5; Crx; Mitf; Neural retina differentiation; Retina pigmented epithelium; Photoreceptors; Bipolar; Dogfish; Multigene family;