
Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates: Design, synthesis and biological evaluation as potential anticancer agents
Keywords: Pyrrolobenzodiazepine; Quinazolinone; DNA binding affinity; Anticancer activity; Molecular modeling; Molecular dynamics; Apoptosis; p53; p21; p27; NF-κB; Cytochrome-c; B-cell lymphoma 2 (Bcl-2); Cyclin dependent kinase-2 (CDK-2); Active caspase-3; Poly (A