Amide-based inhibitors of p38α MAP kinase. Part 2: Design, synthesis and SAR of potent N-pyrimidyl amides
Keywords: p38; MAP; Kinase; Antiinflammatory
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Amide-based inhibitors of p38α MAP kinase. Part 1: Discovery of novel N-pyridyl amide lead molecules
Keywords: p38; MAP; Kinase; Antiinflammatory
X-ray crystal structure of JNK2 complexed with the p38α inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors
Keywords: JNK2; p38; BIRB796; Protein crystallography; X-ray crystal structure; DFG-out; Protein kinase; Kinase inhibitor; Structure-based drug designJNK, c-Jun N-terminal kinase; MAP, mitogen-activated protein
The activation of p38alpha, and not p38beta, mitogen-activated protein kinase is required for ischemic preconditioning
Keywords: βKO; p38β knock-out; I/R%; myocardial infarction as a percentage of myocardium at risk of infarction; DRα; drug-resistant p38α; DRβ; drug-resistant p38β; HSP27; heat stress protein of 27 kDa; MAPK; mitogen-activated protein kinase; MAPKK; mitogen-a
The role of Mitogen activated protein kinase (MAPK) in sperm functions
Keywords: MAPK; ERK; p38; Spermatogenesis; Spermatozoa; Sperm motility
Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells
Keywords: Chronic oxidative stress; Tau phosphorylation; Alzheimer's disease; JNK; p38; PP2A
Lefty antagonises TGF-β1 induced epithelial–mesenchymal transition in tubular epithelial cells
Keywords: Renal fibrosis; E-cadherin; α-Smooth muscle actin; Smad; JNK; p38
Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition
Keywords: p38; Kinase; Triazolopyridines
Tri- and tetrasubstituted imidazoles as p38α mitogen-activated protein kinase inhibitors
Keywords: p38; MAP kinase; Pyridinylimidazoles; ATP competitive inhibitors
Part 2: Structure–activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase
Keywords: p38; MAP kinase; TNF; Pyrazolopyridazine
Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors
Keywords: p38; Kinase; Pyrimidines; TNF-α; IL-1β
YC-1 enhances natural killer cell differentiation from hematopoietic stem cells
Keywords: YC-1; NK cells; Differentiation; Hematopoietic stem cells; p38
Comparative study of p38 MAPK signal transduction pathway of peripheral blood mononuclear cells from patients with coal-combustion-type fluorosis with and without high hair selenium levels
Keywords: Fluorosis; Selenium; p38; NF-kB p65; Caspase-3; Signal transduction pathway; p53
Development of an indirect ELISA test using an affinity purified surface antigen (P38) for sero-diagnosis of canine Neospora caninum infection
Keywords: Neospora caninum; Dog; ELISA; NcSRS2; P38; Canine neosporosis
Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells
Keywords: Dorsomorphin; LDN-193189; BMP signalling; p38; Akt
Biochemical and biophysical characterization of unique switch pocket inhibitors of p38α
Keywords: Kinase; Switch pocket; p38; DFG-out
Differential induction of MAP kinase signalling pathways by cadmium in primary cultures of mouse embryo limb bud cells
Keywords: JNK; p38; MAPK; Signal transduction; Embryotoxicity; Cadmium; Mouse; Limb bud
Human bone marrow-derived stromal cells show highly efficient stress-resistant adipogenesis on denatured collagen IV matrix but not on its native counterpart: Implications for obesity
Keywords: NC I; native collagen I matrix; DC I; denatured collagen I matrix; TCP; tissue culture plastic; ERK; extracellular signal-regulated kinase; p38; p38 mitogen-activated protein kinase; Raf or Raf-1; serine/threonine-specific kinase in ERK activating cascade
Pharmacological profile of AW-814141, a novel, potent, selective and orally active inhibitor of p38 MAP kinase
Keywords: MAP kinases; p38; Inflammation; Arthritis; Tumor necrosis factor-α; Interleukin; Kinases; Collagen-induced arthritis
Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice
Keywords: Resveratrol; Chronic colitis; Cytokines; COX-2; iNOS; p38
Parathyroid hormone(1-34)-induced apoptosis in neuronal rat PC12 cells: Implications for neurotoxicity
Keywords: Parathyroid hormone(1-34); PC12 cell; Cytotoxicity; ERK; p38
JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoter
Keywords: Palmitic acid (hexadecanoic acid); Thrombomodulin; JNK; p38; ATF-2; Histone deacetylase4 (HDAC4)
Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice
Keywords: Hypoxia-ischemia; G protein-coupled receptor kinase 2; Microglia; p38; TNF-α; Minocycline; Neonatal; Neuron;
Enhanced selectivity profile of pyrazole-urea based DFG-out p38α inhibitors
Keywords: Kinase inhibitor; p38; Pyrazole-urea; DFG-out
PAF exerts a direct apoptotic effect on the rat H9c2 cardiomyocytes in Ca2+-dependent manner
Keywords: PAF; Ca2+; p38; Apoptosis; Ischemia; Caspase-3
Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia
Keywords: ASK1; apoptosis-sensitive kinase; MAPK; mitogen-activated protein kinase; MAPKK/MKK; MAPK kinase; MAPKKK; MAPKK kinase; JNK; c-Jun N-terminal kinase; ERK; extracellularly regulated kinase; SAPK; stress-activated protein kinase; MEKK; MAPK/ERK kinase; MLK;
Additive effects of C2-ceramide on paclitaxel-induced premature senescence of human lung cancer cells
Keywords: p38; Senescence; Paclitaxel; Ceramide; p21waf1/cip1
Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli
Keywords: p53; CK2; p38; Phosphorylation; Serine 392;
Glycogen synthase kinase-3 and p38 MAPK are required for opioid-induced microglia apoptosis
Keywords: Opioids; Microglia; Akt; GSK3β; p38; Apoptosis
Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy
Keywords: Curcumin analogs; EF24; p38; p38 inhibitors; Lung cancer
Inhibition of centriole duplication by centrobin depletion leads to p38–p53 mediated cell-cycle arrest
Keywords: Centrobin; Centrosome; G1–S arrest; p53; p38
Building arks for tRNA: Structure and function of the Arc1p family of non-catalytic tRNA-binding proteins
Keywords: tRNA; Arc1p; Trbp111; p43; p38; p18aaRS, aminoacyl-tRNA synthetase; NLS, nuclear localization signal; NES, nuclear export signal
Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure
Keywords: MTK1; Heart failure; Apoptosis; p38; JNK
The multikinase inhibitor Sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE2 in murine macrophages
Keywords: Sorafenib; IL-12; p38; MSK; Macrophages
Negative modulation of invariant natural killer T cell responses to glycolipid antigens by p38 MAP kinase
Keywords: α-galactosylceramide; NKT cell; MAPK; p38; Signaling
Treatment with Histone Deacetylase Inhibitor Attenuates MAP Kinase Mediated Liver Injury in a Lethal Model of Septic Shock1
Keywords: septic shock; acetylation; LPS; suberoylanilide hydroxamic acid; histone; MAP kinase; p38; ERK; IL-10; IL-6; liver
Curcumin p38-dependently enhances the anticancer activity of valproic acid in human leukemia cells
Keywords: Valproic acid; Curcumin; Histone deacetylase; Leukemia; p38; bax;
Peripheral Formalin Injury Induces 2 Stages of Microglial Activation in the Spinal Cord
Keywords: Microglia; spinal cord; formalin; mitogen-activated protein kinases; p38
KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase
Keywords: p38; Kinase; Inhibitor; TNF (Tumor necrosis factor); Arthritis
ES936 stimulates DNA synthesis in HeLa cells independently on NAD(P)H:quinone oxidoreductase 1 inhibition, through a mechanism involving p38 MAPK
Keywords: DCFH-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DZQ; 2,5 bis-[1-aziridyl]-1,4 benzoquinone; ES936; 5-methoxy-1,2-dimethyl-3-[(4-nitrophenol)methyl]-indole-4,7-dione; FCS; fetal calf serum; Het; hydroethidine; NQO1, NAD(P)H; quinone oxidoreductase
Microglial/macrophage GRK2 determines duration of peripheral IL-1β-induced hyperalgesia: Contribution of spinal cord CX3CR1, p38 and IL-1 signaling
Keywords: Microglia; Inflammatory hyperalgesia; G protein-coupled receptor kinase 2; IL-1β; CX3CR1; p38;
Pain MechanismResearch PaperA cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia
Keywords: pain; PSD-95; hyperalgesia; WDR; LTP; p38; CCI; chronic constriction injury; PDZ; PSD-95 Discs large, Zona occludens 1; PSD; post-synaptic density protein; PWL; paw withdrawal latencies; TMR; tetramethylrhodamine; TS; tetanic stimulation; WDR; wide dynami
αA-Crystallin associates with α6 integrin receptor complexes and regulates cellular signaling
Keywords: chaperone; lens; apoptosis; integrin; ERK; p38; JNK
Multiple protein kinase pathways mediate amplified IL-6 release by human lung fibroblasts co-exposed to nickel and TLR-2 agonist, MALP-2
Keywords: Airborne particulate-derived metals; Mitogen-activated protein kinase; p38; Phosphoinositide 3-kinase; Cyclooxygenase; Hypoxia-inducible factor-1α; Innate immunity; Cytokines
Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors
Keywords: B-Raf; p38; Type-II; Allosteric; Kinase inhibitor; Structure-base design; de novo
Riluzole protects against glutamate-induced slowing of neurofilament axonal transport
Keywords: Amyotrophic lateral sclerosis; Motor neuron disease; Extracellular-regulated kinase; p38; Neurofilament; Axonal transport
Peroxynitrite-induced p38 MAPK pro-apoptotic signaling in enterocytes
Keywords: Necrotizing enterocolitis; Nitric oxide; Peroxynitrite; Enterocytes; p38; AKT
Part 1: Structure–Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase
Keywords: p38; MAP kinase; TNF; Pyrazolopyridinone