دانلود مقالات ISI درباره P450، سیتوکروم P450 + ترجمه فارسی

سمیت سلولهای نفتالین در موشهای کمبود هیدرولاز اپوکسی میکروسیمال

Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice

Keywords: P450، سیتوکروم P450; P450, cytochrome P450; GSH, glutathione; GST, glutathione transferase; KO, knockout; mEH, microsomal epoxide hydrolase; NA, naphthalene; NQ, naphthoquinone; OSHA, Occupational Safety and Health Administration; WT, wild typeCytochrome P450; Cell injury/cel

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

سیگنال زیستی توسط مولکول های معدنی کوچک

Biological signaling by small inorganic molecules

Keywords: P450، سیتوکروم P450; ALDH, aldehyde dehydrogenase; CGRP, calcitonin gene-related peptide; CO, carbon monoxide; COX, cyclooxygenase; CBS, cystathionine β-synthase; CSE, cystathionine γ-lyase; P450, cytochrome P450; N2O3, dinitrogen trioxide; N2O4, dinitrogen tetraoxide; GAPDH,

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

استنشاق دی اکسید گوگرد باعث کاهش کیفیت اسپرم و تغییر بافت شناسی بیضه از طریق افزایش بیان پروتئین های CREM و ACT در بافت بیضه موش می شود

Sulfur dioxide inhalation lowers sperm quality and alters testicular histology via increasing expression of CREM and ACT proteins in rat testes

Keywords: P450، سیتوکروم P450; SO2, sulfur dioxide; P450, cytochrome P450; CREM, cAMP-responsive element modulator; ACT, activator of CREM; CYPs, 17 cytochrome P450; E2, 17β-estradiol; CRE, response element; DAB, 3,3′-diaminobenzidine; CTRL, control; H.E, eosin hematoxylinSulfur dioxid

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Two mutations in nAChR beta subunit is associated with imidacloprid resistance in the Aphis gossypii

Keywords: P450، سیتوکروم P450; nAChR, nicotinic acetylcholine receptor; P450, cytochrome P450; ABC transporter, ATP binding cassette transporter; GST, glutathione S-transferase; UGT, UDP-glucuronosyltransferase; NGS, next generation sequencing; 2DE, two-dimentional electrophoresis; IEF

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway

Keywords: P450، سیتوکروم P450; B[a]P, benzo[a]pyrene; P450, cytochrome P450; DHA, docosahexaenoic acid; DPA, docosapentaenoic acid; EPA, eicosapentaenoic acid; ER, endoplasmic reticulum; HPLC, high-performance liquid chromatography; MUFA, monounsaturated fatty acid; PUFA, polyunsaturat

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation

Keywords: P450، سیتوکروم P450; ARE, Antioxidant response element; Nrf2, Nuclear factor erythroid 2-like 2; KO, Knockout; WT, Wild-type; P450, Cytochrome P450; NASH, Nonalcoholic steatohepatitis; NAFLD, Nonalcoholic fatty liver disease; co-IP, Co-immunoprecipitationCoumarin 7-hydroxylas

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Bimodal action of miroestrol and deoxymiroestrol, phytoestrogens from Pueraria candollei var. mirifica, on hepatic CYP2B9 and CYP1A2 expressions and antilipid peroxidation in mice

Keywords: P450، سیتوکروم P450; BROD, benzyloxyresorufin O-dealkylase; ES, estradiol benzoate; MDA, malondialdehyde; mRNA, messenger RNA; MROD, methoxyresorufin O-dealkylase; NADPH, reduced nicotinamide adenine dinucleotide phosphate; P450, cytochrome P450; PCR, polymerase chain reactio

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling

Keywords: P450، سیتوکروم P450; Benzo[a]pyrene; Cytochrome P450; Cytochrome P450 oxidoreductase; DNA adducts; Immunohistochemistry; Polycyclic aromatic hydrocarbonBaP, benzo[a]pyrene; BPDE, benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide; Cyt b5, cytochrome b5; P450, cytochrome P450; HRN, H

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

High-resolution melting curve analysis to establish CYP2C19∗2 single nucleotide polymorphism: Comparison with hydrolysis SNP analysis

Keywords: P450، سیتوکروم P450; Single nucleotide polymorphism; High-resolution melting curve analysis; Hydrolysis SNP analysis; CYP2C19∗2HRM, high-resolution melting curve; P450, cytochrome P450; PCR, polymerase chain reaction; SNP, single nucleotide polymorphism

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Metabolism related toxicity of diclofenac in yeast as model system

Keywords: P450، سیتوکروم P450; GSH, glutathione; HLM, human liver microsomes; NSAID, nonsteroidal anti-inflammatory drug; P450, cytochrome P450; ROS, reactive oxygen speciesDiclofenac; Yeast; Cytochrome P450; Oxidative metabolism; Reactive oxygen species

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Gender-associated modulation of inducible CYP1A1 expression by andrographolide in mouse liver

Keywords: P450، سیتوکروم P450; AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; B6, C57BL/6; D2, DBA/2; EROD, ethoxyresorufin O-deethylase; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; 3-MC, 3-methylcholanthrene; P450, cytochrome P450; PAH, polycyclic aromatic hydroc

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Characterization of a new cytochrome P450 enzyme, CYP2S1, in rats: Its regulation by aryl hydrocarbon receptor agonists

Keywords: P450، سیتوکروم P450; P450, cytochrome P450; AhR, aryl hydrocarbon receptor; 3-MC, 3-methylcholanthrene; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; ARNT, aryl hydrocarbon receptor nuclear translocator; XRE, xenobiotic response element; cDNA, complementary deoxyribonucleic acid

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Metabolic stability of superoxide and hydroxyl radical adducts of a cyclic nitrone toward rat liver microsomes and cytosol: A stopped-flow ESR spectroscopy study

Keywords: P450، سیتوکروم P450; AscOx, ascorbic acid oxidase; BSA, bovine serum albumin; BocMPO, 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide; P450, cytochrome P450; DEPMPO, 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide; DPI, diphenyliodonium; DMPO, 5,5-dimethyl-1-pyrroline N-

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Identification of amino acid residues involved in 4-chloroindole 3-hydroxylation by cytochrome P450 2A6 using screening of random libraries

Keywords: P450، سیتوکروم P450; P450, cytochrome P450; NPR, NADPH-cytochrome P450 reductase; SRS, substrate recognition sites; PCR, polymerase chain reaction; epPCR, error-prone PCR; IPTG, d-isopropyl-β-thiogalactopyranoside; APCI, atmospheric pressure chemical ionization; WT, wild type

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s

Keywords: P450، سیتوکروم P450; P450, cytochrome P450; CPZ-SG, chlorpromazine GSH conjugate; TDZ-SG, thioridazine GSH conjugate; PI, precursor ion; EPI, enhanced product ion; HLM, human liver microsomes; GSH, glutathioneBioactivation; Reactive metabolites; Chlorpromazine; Thioridazine;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease

Keywords: P450، سیتوکروم P450; P450, cytochrome P450; TLR4, toll-like receptor 4; DSS, dextran sulfate sodium; TNBS, trinitrobenzenesulfonic acid; IL, interleukin; TNFα, tumor necrosis factor alpha; LPS, lipopolysaccharide; PMN, polymorphonuclear lymphocytes; PPARα, peroxisome prolifer

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Myotoxicity of gemfibrozil in Cynomolgus monkey model and its relationship to pharmacokinetic properties

Keywords: P450، سیتوکروم P450; PPAR, peroxisome proliferator-activated receptor; P450, cytochrome P450; UGT, UDP-glucuronosyltransferases; AUC, area under concentration–time curve; Cmax, peak concentration; T1/2, elimination half-life; CMC-Na, sodium carboxymethylcellulose; HPLC, high

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice

Keywords: P450، سیتوکروم P450; P450, cytochrome P450; EROD, 7-ethoxyresorufin O-deethylation; PROD, 7-pentoxyresorufin O-dealkylation; NDM, nitrosodimethylamine N-demethylation; NFO, nifedipine oxidationSophora flavescens; Cytochrome P450; Mice; Gender; Liver

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

The monoterpenoids citral and geraniol are moderate inhibitors of CYP2B6 hydroxylase activity

Keywords: P450، سیتوکروم P450; P450, cytochrome P450; HLM, human liver microsomes; LC/MS/MS, liquid chromatography/tandem mass spectrometryMonoterpenoids; Inhibition; CYP2B6; Bupropion; Citral; Geraniol

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

The influence of Sutherlandia frutescens on adrenal steroidogenic cytochrome P450 enzymes

Keywords: P450، سیتوکروم P450; HPA, hypothalamic–pituitary–adrenal; GABA, gamma-aminobutyric acid; P450, cytochrome P450; CYP17, P450 17α-hydroxylase; PREG, pregnenolone; 17OH-PREG, 17-hydroxypregnenolone; DHEA, dehydroepiandrosterone; PROG, progesterone; 17OH-PROG, 17-hydroxyprogester

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s

Keywords: P450، سیتوکروم P450; P450, cytochrome P450; TCAs, tricyclic antidepressants; PI, precursor ion; EPI, enhanced product ion; HLM, human liver microsomes; GSH, glutathioneAmitriptyline; Nortriptyline; Bioactivation; P450; Hepatotoxicity; Arene oxide

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites

Keywords: P450، سیتوکروم P450; P450, cytochrome P450; NAPQI, N-acetyl-p-benzoquinoneimine; tr, retention time; ADRs, adverse drug reactions; IDRs, idiosyncratic drug reactions; GSH, glutathione; RLM, rat liver microsomes; HLM, human liver microsomesReactive metabolites; Adverse drug re

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Role of Gln 85 of human CYP27A1 in 25-hydroxyvitamin D3-binding and protein folding

Keywords: P450، سیتوکروم P450; P450, cytochrome P450; CYP, cytochrome P450; ADR, NADPH-adrenodoxin reductase; ADX, adrenodoxin; 25(OH)D3, 25-hydroxyvitamin D3; 1α,25(OH)2D3, 1α,25-dihydroxyvitamin D3; VDDR-I, vitamin D-dependent rickets type I; CTX, cerebrotendinous xanthomatosisCYP27A

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

The in vitro metabolism of a pyrethroid insecticide, permethrin, and its hydrolysis products in rats

Keywords: P450، سیتوکروم P450; PBAlc, 3-phenoxybenzyl alcohol; PBAld, 3-phenoxybenzaldehyde; PBAcid, 3-phenoxybenzoic acid; HPLC, high-performance liquid chromatography; P450, cytochrome P450; CES, carboxylesteraseCarboxylesterase; Cytochrome P450; Trans-permethrin; Cis-permethrin; 3-p

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: Structure–effect relationships and evidence for an allosteric mechanism

Keywords: P450، سیتوکروم P450; UGT, UDP-glucuronosyltransferase; E3G, Estradiol 3β-d-glucuronide; E17G, Estradiol 17β-d-glucuronide; 4-MU, 4-methylumbelliferone; UDP-GlcA, uridine 5′-diphosphoglucuronic acid; P450, cytochrome P450; G6P, glucose-6-phosphate; 11β-HSD, 11β-hydroxysteroid

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Elevation of 8-hydroxydeoxyguanosine and cell proliferation via generation of oxidative stress by organic arsenicals contributes to their carcinogenicity in the rat liver and bladder

Keywords: P450، سیتوکروم P450; MMAV, monomethylarsonic acid; DMAV, dimethylarsinic acid; TMAOV, trimethylarsine oxide; ROS, reactive oxygen species; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; P450, cytochrome P450; CYP2B1, CYP1A1 and CYP1A2, 2B1, 1A1 and 1A2 isoenzymes of cytochrome P450, re

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

The ins and outs of cytochrome P450s

Keywords: P450، سیتوکروم P450; P450, Cytochrome P450; pw, Pathway; TMP, Thermal motion pathway; RAMD, Random acceleration molecular dynamics; SRS, Substrate Recognition Site; PDB, Protein Databank; Cymal-5, cyclohexyl-pentyl-β-d-maltosideCytochrome P450; Protein dynamics; Ligand bindin

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

Impact of Andrographis paniculata crude extract on mouse hepatic cytochrome P450 enzymes

Keywords: P450، سیتوکروم P450; EROD, ethoxyresorufin O-dealkylation; 3-MC, 3-methylcholanthrene; MROD, methoxyresorufin O-dealkylation; P450, cytochrome P450; PB, phenobarbital sodium; PROD, pentoxyresorufin O-dealkylationAndrographis paniculata; Cytochrome P450; Ethoxyresorufin O-deal

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Vitamin E deficiency accelerates nitrate tolerance via a decrease in cardiac P450 expression and increased oxidative stress

Keywords: P450، سیتوکروم P450; P450, cytochrome P450; NTG, nitroglycerin; NO, nitric oxide; cAK, cAMP-activated protein kinase; cGK-I, cGMP-activated protein kinase I; NOx, nitrite and nitrate; HNE, 4-hydroxy-2-nonenal; MDA, malondialdehyde; ROS, reactive oxygen species; RNS, reactive

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

The regulation of cytochrome P450 2E1 during LPS-induced inflammation in the rat

Keywords: P450، سیتوکروم P450; LPS, lipopolysaccharide; CNS, central nervous system; P450, cytochrome P450; TNFα, tumor necrosis factor alpha; IL-1β, interleukin-1β; IFNγ, interferon gamma; NF-κB, nuclear factor-kappa B; Ap-1, activator protein-1; i.c.v., intracerebroventricular; i.p.,

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol

Keywords: P450، سیتوکروم P450; I.P., intraperitoneally; Mab, monoclonal antibody; 3-MC, 3-methylcholanthrene; P450, cytochrome P450; RT-PCR, reverse transcription-polymerase chain reaction; S-9, postmitochondrialBitertanol; Induction; Inhibition; CYP1A1; CYP2B; CYP3A

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Marine invertebrate cytochrome P450: Emerging insights from vertebrate and insect analogies

Keywords: P450، سیتوکروم P450; AHR, Aryl hydrocarbon receptor; 20E, 20-hydroxyecdysone; BaP, Benzo(a)pyrene; P450, Cytochrome P450; E, Ecdysone; E20MO, Ecdysone 20-monooxygenase; EST, Expressed sequence tag; PAHs, Polycyclic aromatic hydrocarbons; CYP1A IPP, CYP1A immunopositive protei

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2006 سفارش ترجمه

Immunopropylactic approaches against chemical carcinogenesis

Keywords: P450، سیتوکروم P450; B[a]P, benzo[a]pyrene; BPDE, anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; 7,8-diol-B[a]P, 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene; GI, gastrointestinal; P450, cytochrome P450; PAH, polycyclic aromatic hydrocarbonImmunoprophylaxis; Immu

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2005 سفارش ترجمه