Keywords: مدل لوله موازی; compartment model; CYP1A2; CYP2C19; drug interactions; fluvoxamine; parallel tube model; hepatic clearance; pharmacokinetics; prediction; simulation;
مقالات ISI مدل لوله موازی (ترجمه نشده)
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Simulations of Cytochrome P450 3A4-Mediated Drug-Drug Interactions by Simple Two-Compartment Model-Assisted Static Method
Keywords: مدل لوله موازی; bioavailability; cytochrome P450; drug interaction; dynamic simulation; first pass metabolism; hepatic clearance; intestinal metabolism; pharmacokinetics; simulations; parallel tube model; Ae (Ae,oral); dose fractions of urinary excreted unchanged drug af
Dynamic and Static Simulations of Fluvoxamine-Perpetrated Drug-Drug Interactions Using Multiple Cytochrome P450 Inhibition Modeling, and Determination of Perpetrator-Specific CYP Isoform Inhibition Constants and Fractional CYP Isoform Contributions to Vic
Keywords: مدل لوله موازی; compartment model; cytochrome P450; CYP1A2; drug interactions; fluvoxamine; parallel tube model; hepatic clearance; pharmacokinetics; prediction; simulations;
Determination of Hepatic Clearance with the Account of Drug-Protein Binding Kinetics
Keywords: مدل لوله موازی; protein binding kinetics; hepatic clearance; wellâstirred model; parallel tube model; dissociation; drug ionization; extracellular and intracellular water distribution; physiological model; pharmacokinetics;
The Corrected Traditional Equations for Calculation of Hepatic Clearance that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water and the Corresponding Corrected PBPK Equation
Keywords: مدل لوله موازی; hepatic clearance; well-stirred model; parallel tube model; dispersion model; drug ionization; extra- and intracellular water distribution; physiological model; PBPK equation; hepatic uptake and efflux; metabolic elimination; pharmacokinetics;
On the influence of protein binding on pharmacological activity of drugs
Keywords: مدل لوله موازی; protein binding; drug exposure; drug efficiency; bioavailability; wellâstirred model; parallel tube model; dispersion model; tissue-plasma partitioning; clearance; drug-receptor binding;
Prediction of the possibility of the secondary peaks of iv bolus drug plasma concentration time curve by the model that directly takes into account the transit time through the organ
Keywords: مدل لوله موازی; secondary peaks; clearance; transit time; mathematical model; parallel tube model; well-stirred model; pharmacokinetics;