Keywords: PB، فنوباربیتال; AEDs, antiepileptic drugs; PB, phenobarbital; VPA, sodium valproate; NERs, Noda epileptic ratsEpilepsy models; Antiepileptic drugs; EEG; Non-priming; Genetics; Rat
مقالات ISI PB، فنوباربیتال (ترجمه نشده)
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Keywords: PB، فنوباربیتال; AED, antiepileptic drug; ANOVA, analysis of variance; BLA, basolteral amygdala; EEG, electroencephalogram; HPLC, high-performance liquid chromatography; LTG, lamotrigine; NIH, National Institutes of Health; PB, phenobarbital; PHT, phenytoin; SE, status ep
Transdifferentiated rat pancreatic progenitor cells (AR42J-B13/H) respond to phenobarbital in a rat hepatocyte-specific manner.
Keywords: PB، فنوباربیتال; B13/H, AR42J-B13/H cells; Cyp, Cytochrome P450; PB, phenobarbital; PROD, pentoxyresorufin-O-dealkylase; qRT-PCR, quantitative reverse transcription-PCR. BSA bovine serum albumin; Egf, epidermal growth factor; Erl., erlotinib; Veh, vehicle. DMSO dimethyl s
Montelukast potentiates the anticonvulsant effect of phenobarbital in mice: An isobolographic analysis
Keywords: PB، فنوباربیتال; CysLT1, cysteinyl leukotriene receptor 1; PTZ, pentylenetetrazole; COX, cyclooxygenase; LOX, lipoxygenase; LTD4, leukotriene D4; MTK, montelukast; PB, phenobarbital; NaCl, sodium chloride; AED, antiepileptic drug; PGE2, prostaglandine E2; BBB, blood–brain
Role of rat cytochromes P450 in the oxidation of 17α-ethinylestradiol
Keywords: PB، فنوباربیتال; α-NF, α-naphthoflavone; CO, carbon monoxide; CYP, cytochrome P450; DMSO, dimethyl sulfoxide; EE2, 17α-ethinylestradiol; EtOH, ethanol; HPLC, high performance liquid chromatography; OCs, oral contraceptives; PB, phenobarbital; PCN, pregnenolon 16α-carbonit
Time and dose-dependent effects of phenobarbital on the rat liver miRNAome
Keywords: PB، فنوباربیتال; miRNA, microRNA; PB, phenobarbital; CAR, Constitutive Androstane Receptor; ppm, parts per million; pparα, peroxisome proliferator-activated receptorsmicroRNA; Xenobiotic; Dose; Temporal; Proliferation
Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression
Keywords: PB، فنوباربیتال; AMPK, AMP-activated protein kinase; CAR, constitutive androstane receptor; CYP, cytochrome P450; epo, erythropoietin; HRE, hypoxia-responsive element; ho-1, heme oxygenase-1; HIF, hypoxia inducible factor; PHD, prolyl hydoxylase; PB, phenobarbital; PBREM,
Role of the nuclear xenobiotic receptors CAR and PXR in induction of cytochromes P450 by non-dioxinlike polychlorinated biphenyls in cultured rat hepatocytes
Keywords: PB، فنوباربیتال; PCBs, polychlorinated biphenyls; DL, dioxinlike; NDL, non-dioxinlike; CAR, constitutive androstane receptor; PXR, pregnane X receptor; CYP, cytochrome P450; siRNA, small interfering RNA; OA, okadaic acid; PB, phenobarbital; Dex, dexamethasonePolychlorinat
Liver carcinogenesis: Rodent models of hepatocarcinoma and cholangiocarcinoma
Keywords: PB، فنوباربیتال; CCA, cholangiocarcinoma; CCl4, carbon tetrachloride; CDD, choline deficient diet; DEN, N-nitrosodiethylamine; HCC, hepatocellular carcinoma; NAFLD, non-alcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; PB, phenobarbital; PH, partial hepat
Identification and expression analysis of NADH-cytochrome b5 reductase gene in the cotton bollworm, Helicoverpa armigera
Keywords: PB، فنوباربیتال; CBR, NADH-cytochrome b5 reductase; CPR, NADPH-cytochrome P450 reductase; P450s, cytochrome P450 enzyme systems; PB, phenobarbital; TM, trans-membrane; RT-PCR, reverse transcription-polymerase chain reaction; RT-qPCR, real-time quantitative polymerase chai
Modulations of cytochrome P450 expression in diabetic mice by berberine
Keywords: PB، فنوباربیتال; BER, berberine; BNF, beta-naphthoflavone; CF, clofibrate; CYPs, cytochrome P450; DEX, dexamethasone; INH, isoniazid; MET, metformin; PB, phenobarbital; STZ, streptozotocinBerberine; Cytochrome P450; Diabetic mice; Mouse hepatocytes; Streptozotocin
Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes
Keywords: PB، فنوباربیتال; 1-ABT, 1-aminobenzotriazole; BROD, 7-benzyloxyresorufin O-dealkylation; DCF, 2′,7′-dichlorofluorescein; DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; DMSO, dimethylsulfoxide; GSH, glutathione; LDH, lactate dehydrogenase; PB, phenobarbital; VPA, valpr
Successful ECT treatment for medically refractory nonconvulsive status epilepticus in pediatric patient
Keywords: PB، فنوباربیتال; VPA, Valproate; LEV, Levetiracetam; CLB, Clobazam; LOR, Loarzepam; PB, Phenobarbital; MDZ, Midazolam; FEN, Fentanyl; TPM, Topiramate; PEN, Pentobarbital; KET, KetamineStatus epilepticus; Nonconvulsive status epilepticus; Electroconvulsive therapy; Pediatr
Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens
Keywords: PB، فنوباربیتال; FZ, furazolidone; PB, phenobarbital; β-NF, β-naphthoflavone; APN, aminopyrine; APND, aminopyrine N-demethylase; DPI, diphenylene iodonium chloride; DMSO, dimethyl sulfoxideChicken; Cytochrome P450; Furazolidone; Liver; NADPH cytochrome P450 reductase
Induction of a detoxification gene in Drosophila melanogaster requires an interaction between tissue specific enhancers and a novel cis-regulatory element
Keywords: PB، فنوباربیتال; Xenobiotic; Cytochrome P450; Gene regulation; Tissue specific expression; Midgut; DetoxificationCRE, cis-regulatory element; PB, Phenobarbital; P450, cytochrome 450; PXR, pregnane X receptor; CAR, constitutive androstane receptor; AhR, aryl hydrocarbon re
The nuclear import of the constitutive androstane receptor by importin/Ran-GTP systems
Keywords: PB، فنوباربیتال; CAR, constitutive androstane/active receptor; XRS, xenochemical response signal; PB, phenobarbital; NPC, nuclear pore complexes; IPO13, importin 13; NLS, nuclear localization signal; NES, nuclear export signal; GR, glucocorticoid receptor; AR, androgen re
Evaluation of the immunosensitizing potential of chlorogenic acid using a popliteal lymph node assay in BALB/c mice
Keywords: PB، فنوباربیتال; AFCs, antibody-forming cells; CGA, chlorogenic acid; CI, cellularity index; DF, Diclofenac sodium salt; HRs, immune-mediated hypersensitivity reactions; LMWCs, low molecular weight compounds; PB, Phenobarbital; PLNA, popliteal lymph node assay; RA, report
Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region
Keywords: PB، فنوباربیتال; AhR, aryl hydrocarbon receptor; XRE, xenobiotic-responsive element; CYP, cytochrome P450; CAR, constitutive androstane receptor; RXRα, retinoid X receptor α; h, human; PB, phenobarbital; DMEM, Dulbecco's modified Eagle's medium; FBS, fetal bovine serum; C
Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4α
Keywords: PB، فنوباربیتال; CAR, nuclear constitutive active/androstane receptor; PXR, pregnane X receptor; CYP, cytochrome P450; EGR1, early growth response 1; HNF4α, hepatocyte-enriched nuclear factor 4α; OAREKI, OA response element KI; PB, phenobarbital; PBREM, PB responsive enha
Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells
Keywords: PB، فنوباربیتال; PCBs, Polychlorinated biphenyls; DL-PCBs, Dioxin-like-PCBs; NDL-PCBs, Non-dioxin-like-PCBs; TCDD, 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Et, Etoposide; LMB, Leptomycin B; PB, Phenobarbital; HepG2, Human hepatocellular carcinoma cell line; Mdm2, Murine doubl
Chemopreventive compounds—View from the other side
Keywords: PB، فنوباربیتال; AhR, Ah receptor; B[a]P, benzo[a]pyrene; BNF, β-naphthoflavone; CYP, cytochrome P450; DEX, dexametazone; GST, glutathione S-transferase; IQ, 2-amino-3-methylimidazo(4,5-f)quinoline; NAT, N-acetyltransferase; PB, phenobarbital; PCN, pregnenolone-16α-carbon
Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions
Keywords: PB، فنوباربیتال; CAR, constitutive androstane receptor; Cy3-CTP, cyanine 3-cytosine triphosphate; Cy5-CTP, cyanine 5-cytosine triphosphate; CYP450, cytochrome P450; DMSO, dimethyl sulfoxide; FCS, fetal calf serum; IPA, Ingenuity Pathways Analysis; PB, phenobarbital; PCA,
Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species
Keywords: PB، فنوباربیتال; CAR, constitutive activated/androstane receptor; CXR, chicken X receptor; D3T, dithiol-3-thione; Nrf2, nuclear factor (erythroid-derived 2)-like 2; PB, phenobarbital; PCN, pregnenolone 16 alpha-carbonitrile; PFAA, perfluoroalkyl acids; PFDA, perfluorodeca
Involvement of oxidative stress in the hepatotoxicity induced by aromatic antiepileptic drugs
Keywords: PB، فنوباربیتال; AAED, aromatic antiepileptic drugs; CB, carbamazepine; CB-B, bioactivated carbamazepine; GSH, reduced glutathione; GSSG, oxidized glutathione; MDA, malondialdehyde; PB, phenobarbital; PB-B, bioactivated phenobarbital; P-SH, sulfhydryl proteins; PT, phenyt
Cell shape, cell–cell contact, cell–extracellular matrix contact and cell polarity are all required for the maximum induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes
Keywords: PB، فنوباربیتال; apo, apolipoprotein; CAR, constitutive activator receptor; CYP, cytochrome P-450; EHS, Engelbreth-Holm-Swan; IDPN, 3,3′-iminodipropionitrile; PB, phenobarbital; TIC, type I collagen; TIVC, type IV collagen; UGT, UDP-glucuronosyltransferaseHepatocyte; Phen
Coordinated induction of drug transporters and phase I and II metabolism in human liver slices
Keywords: PB، فنوباربیتال; PB, phenobarbital; BNF, β-naphthoflavone; RIF, rifampicin; CAR, constitutive androstane receptor; AhR, aryl hydrocarbon receptor; PXR, steroid and xenobiotics receptor; 7-EC, 7-ethoxycoumarin; BSEP (ABCB11), canalicular bile salt export pump; 7-HC, 7-hydr
Application and interpretation of hPXR screening data: Validation of reporter signal requirements for prediction of clinically relevant CYP3A4 inducers
Keywords: PB، فنوباربیتال; CAR, constitutive androstane receptor; CYP, cytochrome P450; DEX, dexamethasone; GR, glucocorticoid receptor; NCEs, new chemical entities; PB, phenobarbital; PCN, pregnenolone 16α-carbonitrile; PPAR, peroxisome proliferator activated receptor; PXR, pregna
Aromatic antiepileptic drugs and mitochondrial toxicity: Effects on mitochondria isolated from rat liver
Keywords: PB، فنوباربیتال; AAED, aromatic antiepileptic drugs; AED, antiepileptic drugs; CB, carbamazepine; CB-B, bioactivated carbamazepine; CCCP, carbonyl cyanide m-chlorophenylhydrazone; PB, phenobarbital; PB-B, bioactivated phenobarbital; PT, phenytoin; PT-B, bioactivated pheny
Benign infantile convulsions associated with mild gastroenteritis: A retrospective study of 39 cases including virological tests and efficacy of anticonvulsants
Keywords: PB، فنوباربیتال; Benign convulsions; Mild gastroenteritis; Rotavirus; Norovirus; CarbamazepineCBZ, carbamazepine; CwG, benign convulsions associated with mild gastroenteritis; DZP, diazepam; EEG, electroencephalogram; MDZ, midazolam; PB, phenobarbital; PHT, phenytoin.
Assessment of hepatocellular damage and hematological alterations in mice chronically fed p-dimethyl aminoazobenzene and phenobarbital
Keywords: PB، فنوباربیتال; GSH, reduced glutathione; Hb, hemoglobin; MMP, matrix metalloproteinase; p-DAB, p-dimethyl aminoazobenzene; PB, phenobarbital; SEM, scanning electron microscopy; TEM, transmission electron microscopyReduced glutathione; Hemoglobin; Matrix metalloproteinas
Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy
Keywords: PB، فنوباربیتال; AED, antiepileptic drug; DRRC, dose–response relationship curve; GABA, γ-aminobutyric acid; MES, maximal electroshock seizures; MEST, maximal electroshock seizure threshold; MPAE, maximum possible antinociceptive effect; PB, phenobarbital; PTZ, pentylenet
A sandwich-cultured rat hepatocyte system with increased metabolic competence evaluated by gene expression profiling
Keywords: PB، فنوباربیتال; CYP450, cytochrome P450; PB, phenobarbital; DEX, dexamethasone; β-NF, β-naphthoflavone; DMEM, Dulbecco’s modified Eagle’s medium; FCS, fetal calf serum; PBS, phosphate buffered saline; KHB, Krebs Henseleit buffer; CTP, cytosine triphosphate; DMSO, dimethy
Epileptic fits and epilepsy in the elderly: General reflections, specific issues and therapeutic implications
Keywords: PB، فنوباربیتال; AD, Alzheimer's disease; AED(s), anti-epileptic drug(s); CBZ, carbamazepine; CNS, central nervous system; CYP, cytochrome P; GBP, gabapentin; LTG, lamotrigine; LEV, levetiracetam; OXC, oxcarbazepine; PGB, pregabalin; PB, phenobarbital; PHT, phenytoin; PRM
An in vivo and in vitro comparison of CYP gene induction in mice using liver slices and quantitative RT-PCR
Keywords: PB، فنوباربیتال; CYP, cytochrome P450; RT, reverse transcription; PCR, polymerase chain reaction; βNF, β-naphthoflavone; PB, phenobarbital; DEX, dexamethasone; dNTP, 2′-deoxynucleoside 5′-triphosphate; dATP, 2′-deoxyadenine 5′-triphosphate; dGTP, 2′-deoxyguanine 5′-tripho
Cytotoxicity of sanguinarine in primary rat hepatocytes is attenuated by dioxin and phenobarbital
Keywords: PB، فنوباربیتال; AhR, aryl hydrocarbon receptor; CYP, cytochrome P450; EROD, 7-ethoxyresorufin-O-deethylase; FURA, furafylline; PB, phenobarbital; QBA, quaternary benzo[c]phenanthridine alkaloid; SA, sanguinarine; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxinSanguinarine; Cyt
Proximal HNF1 element is essential for the induction of human UDP-glucuronosyltransferase 1A1 by glucocorticoid receptor
Keywords: PB، فنوباربیتال; UGT, UDP-glucuronosyltransferase; PB, phenobarbital; PBREM, PB response enhancer module; DE, distal element; DEX, dexamethasone; GR, human glucocorticoid receptor; GRE, glucocorticoid responsive element; CAR, constitutive androstane receptor; PXR, human p
Localization of the nuclear receptor CAR at the cell membrane of mouse liver
Keywords: PB، فنوباربیتال; PB, phenobarbital; BN-PAGE, blue native polyacrylamide gel electrophoresis; SDS–PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresisNuclear receptor; CAR; Phenobarbital; Nuclear translocation; Cytochrome P450; Drug metabolism and transport