
Melanocortin 1 receptor mutations impact differentially on signalling to the cAMP and the ERK mitogen-activated protein kinase pathways
Keywords: GPCR, G protein-coupled receptor; MC1R, melanocortin 1 receptor; NDP-MSH, norleucine4d-phenylalanine7-melanocyte-stimulating hormone; RHC, red hair colour; MAPK, mitogen-activated protein kinase; PC12, rat pheochromocytoma cell line; wtMC1R, wild-type MC1