دانلود مقالات ISI درباره PDE، فسفودی استراز + ترجمه فارسی

اصلاح یک سیکلاز-فسفودی استراز دیوژنیلات دو طرفه برای تولید موثر دیوگانیلات مونوفسفره

Modification of a bi-functional diguanylate cyclase-phosphodiesterase to efficiently produce cyclic diguanylate monophosphate

Keywords: PDE، فسفودی استراز; Cyclic-diGMP, bis-3′-5′-cyclic dimeric guanosine monophosphate; GTP, guanosine-5′-triphosphate; pGpG, 5′-phosphoguanylyl-(3′,5′)-guanosine); DGC, diguanylate cyclase; PDE, phosphodiesterase; AvHaCE, Agrobacterium vitis H-NOX associated cyclic-diGMP proces

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

نقش YddV سنسور گلوبین همراه در یک جمعیت بیوفیلم اشرشیاکلی بالغ

The role of the globin-coupled sensor YddV in a mature E. coli biofilm population

Keywords: PDE، فسفودی استراز; AB, antibiotics; c-di-GMP, cyclic di-guanosine monophosphate; CV, crystal violet; DGC, diguanylate cyclase; GCS, globin-coupled sensor; IPTG, isopropyl β-d-1-thiogalactopyranoside; PDE, phosphodiesterase; PGA, poly-N-acetylglucosamineGlobin-coupled sensor

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Validation of a UPLC–MS/MS method for the simultaneous determination of E6005, a phosphodiesterase 4 inhibitor, and its metabolite in human plasma

Keywords: PDE، فسفودی استراز; HQ, Chigh QC; IS, internal standard; LLOQ, lower limit of quantification; LQC, low QC; MQC, middle QC; PDE, phosphodiesterase; QC, quality control; RE, relative error; RSD, relative standard deviations; ULOQ, upper limit of quantification; UPLC–MS/MS, ult

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Antipruritic mechanisms of topical E6005, a phosphodiesterase 4 inhibitor: Inhibition of responses to proteinase-activated receptor 2 stimulation mediated by increase in intracellular cyclic AMP

Keywords: PDE، فسفودی استراز; cAMP, cyclic adenosine 3′,5′-monophosphate; EIA, enzyme immunoassay; IgG, immunoglobulin G; LTB4, leukotriene B4; PDE, phosphodiesterase; PAR2, proteinase-activated receptor 2; PBS, phosphate-buffered salinecAMP; Itch; Phosphodiesterase; Proteinase-activa

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery of tetrahydropyrido[4,3-d]pyrimidine derivatives for the treatment of neuropathic pain

Keywords: PDE، فسفودی استراز; GABA, gamma-aminobytyric acid; NMDA, N-methyl-D-aspartate; AMPA, 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid; PDE, phosphodiesterase; P2X7, purinoreceptor subtype; DCM, dichloromethane; THF, tetrahydrofuran; DMF, dimethyl formamide; ELISA,

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Investigation of cAMP microdomains as a path to novel cancer diagnostics

Keywords: PDE، فسفودی استراز; cAMP, Cyclic adenosine monophosphate; sAC, Soluble adenylyl cyclase; tmAC, Transmembrane adenylyl cyclase; PDE, Phosphodiesterase; PKA, Protein kinase A; AKAP, A kinase anchoring protein; EPAC, Exchange protein activated by cAMP; GEF, Guanine nucleotide e

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Sarcoplasmic reticulum Ca2 + cycling protein phosphorylation in a physiologic Ca2 + milieu unleashes a high-power, rhythmic Ca2 + clock in ventricular myocytes: Relevance to arrhythmias and bio-pacemaker design

Keywords: PDE، فسفودی استراز; AP, action potential; β-ARs, β-adrenergic receptor stimulation; Ca2 +, calcium; IBMX, isobutyl-1-methylxanthine; LCR, local Ca2 + releases; PDE, phosphodiesterase; PKA, protein kinase A; PLB, phospholamban; PP, protein phosphatases; RyRs, ryanodine recept

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Levodopa-induced dyskinesias are associated with transient down-regulation of cAMP and cGMP in the caudate-putamen of hemiparkinsonian rats: Reduced synthesis or increased catabolism?

Keywords: PDE، فسفودی استراز; cAMP, cyclic adenosine monophosphate; cGMP, cyclic guanosine monophosphate; PDE, phosphodiesterase; 6-OHDA, 6-hydroxydopamine; PDE10A, phosphodiesterase 10A; PDE1B, phosphodiesterase 1BParkinson disease; Levodopa dyskinesia; cAMP; cGMP; Phopsphodiesterase

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

The c-di-GMP recognition mechanism of the PilZ domain of bacterial cellulose synthase subunit A

Keywords: PDE، فسفودی استراز; c-di-GMP, cyclic dimeric guanosine monophosphate; ITC, isothermal titration calorimetry; CeS, cellulose synthase; DGC, diguanylate cyclase; PDE, phosphodiesterase; STING, stimulator of interferon genesX-ray crystallography; PilZ domain; c-di-GMP; Bacteria

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Effect of sildenafil, a selective phosphodiesterase 5 inhibitor, on the anticonvulsant action of some antiepileptic drugs in the mouse 6-Hz psychomotor seizure model

Keywords: PDE، فسفودی استراز; PDE, phosphodiesterase; NO, nitric oxide; cGMP, cyclic guanosine 3′,5′-monophosphate; NOS, nitric oxide synthase; GC, guanylate cyclase; PKG, cGMP-dependent protein kinase; PTZ, pentylenetetrazole; MES, maximal electroshock seizures; MEST, maximal electro

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Neuronal expression of soluble adenylyl cyclase in the mammalian brain

Keywords: PDE، فسفودی استراز; cAMP, Cyclic 3′,5′-adenosine monophosphate; PDE, phosphodiesterase; sAC, Soluble adenylyl cyclase (ADCY10, Sacy); HCO3−, bicarbonate; WT, wild type; C1KO, Sacytm1Lex/Sacytm1Lex or sAC-C1 domain knockout mice; C2KO, ADCY10del/ADCY10del or sAC-C2 domain kno

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes – A role for the transcription factor NFAT and phosphodiesterase 3B

Keywords: PDE، فسفودی استراز; CL, CL316,243; GIP, glucose-dependent insulinotropic polypeptide; GSK, glycogen synthase kinase; NFAT, nuclear factor of activated T-cells; PDE, phosphodiesterase; PKB, protein kinase B; T2D, type 2 diabetesOsteopontin; GIP; Adipocytes; NFAT; Phosphodiest

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Simultaneous LC–MS/MS analysis of the biomarkers cAMP and cGMP in plasma, CSF and brain tissue

Keywords: PDE، فسفودی استراز; cAMP, cyclic adenosine-3′,5′-monophosphate; cGMP, cyclic guanosine-3′,5′-monophosphate; PDE, phosphodiesterase; LC–MS/MS, liquid chromatography coupled to tandem mass spectrometry; MRM, multiple reaction monitoring; aCSF, artificial cerebrospinal fluid; I

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D

Keywords: PDE، فسفودی استراز; AC, adenylyl cyclase; PDE, phosphodiesterase; PHD, prolyl hydroxylase domain protein; H9c2 cells, a cell line derived from embryonic rat heart; SDS, sodium dodecyl sulfate; PAGE, polyacrylamide gel electrophoresiscAMP; Prolyl hydroxylase domain protein; A

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Tadalafil for the Treatment of Pulmonary Arterial Hypertension : A Double-Blind 52-Week Uncontrolled Extension Study

Keywords: PDE، فسفودی استراز; PDE-5; pulmonary arterial hypertension; tadalafilAE, adverse event(s); PAH, pulmonary arterial hypertension; PDE, phosphodiesterase; 6MWD, 6-min walk distance; T20 mg, tadalafil 20 mg; T40 mg, tadalafil 40 mg; WHO-FC, World Health Organization functional

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa

Keywords: PDE، فسفودی استراز; c-di-GMP, cyclic diguanylic acid; DGC, diguanylate cyclase; PDE, phosphodiesterase; pGpG, linear diguanylic acid; 2′-AHC-c-di-GMP, 2′-aminohexylcarbamoyl-c-di-GMP; NHS, N-hydroxysuccinimide; 2′-Fluo-AHC-c-di-GMP, 2′-O-(6-[Fluoresceinyl]-aminohexylcarbamoy

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Validated RP-UHPLC PDA and GC–MS methods for the analysis of psychoactive alkaloids in Sceletium tortuosum

Keywords: PDE، فسفودی استراز; CNS, central nervous system; ICH, International Conference of Harmonisation; PDE, phosphodiesterase; SIM, selective ion monitoring; PDA, photodiode array; Sa, uncertainty in the y intercept; Sb, uncertainty in the slope; Sy/x, random calibration uncertain

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Multistate Allostery in Response Regulators: Phosphorylation and Mutagenesis Activate RegA via Alternate Modes

Keywords: PDE، فسفودی استراز; BME, β-mercaptoethanol; HDXMS, hydrogen/deuterium exchange mass spectrometry; PDE, phosphodiesterase; RR, response regulator; PDB, Protein Data Bankprotein dynamics; phosphoaspartate signaling; amide hydrogen/deuterium exchange mass spectrometry; conforma

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2012 سفارش ترجمه

Effects of testosterone on the lower urinary tract go beyond the prostate: New insights, new treatment options

Keywords: PDE، فسفودی استراز; DHT, dihydrotestosterone; ED, erectile dysfunction; DHEA-S, dehydroepiandrosterone sulphate; LOH, late-onset hypogonadism; NO(S), nitric oxide (synthase); PDE, phosphodiesterase; TU, testosterone undecanoateTestosterone; Prostate; Lower urinary tract symp

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Combined intracavernous vasoactive drugs and sildenafil citrate in treatment of severe erectile dysfunction not responding to on-demand monotherapy

Keywords: PDE، فسفودی استراز; ED, erectile dysfunction; CDUS, colour Doppler ultrasonography; PGE1, prostaglandin E1; EH(S), Erection Hardness (Score); ICI, intracavernous injection; PSV, peak systolic velocity; EDV, end-diastolic velocity; RI, resistance index; PDE, phosphodiesterase

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Cilomilast counteracts the effects of cigarette smoke in airway epithelial cells

Keywords: PDE، فسفودی استراز; TLR4, Toll like receptor 4; COPD, Chronic obstructive pulmonary disease; CSE, Cigarette smoke extracts; LPS, Lipopolysaccharide; PDE, Phosphodiesterase; cAMP, Cyclic AMP; CIL, CilomilastPhosphodiesterase inhibitors; Toll like receptors; Cigarette smoke; A

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Nitric oxide affects IL-6 expression in human peripheral blood mononuclear cells involving cGMP-dependent modulation of NF-κB activity

Keywords: PDE، فسفودی استراز; IL-6; NF-κB; Nitric oxide; cGMP; PBMCEMSA, electrophoretic mobility shift assay; GC, guanylyl cyclase; GSNO, S-nitrosoglutathione; IBMX, 3-isobutyl-1-methylxanthine; ODQ, 1H-[1,2,4]oxadiazolo[4,3-α]quinoxalin-1-one; PDE, phosphodiesterase; PKG, cGMP-depen

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Effect of bitter compounds on amylase secretion in murine submandibular glands: Signaling pathway mechanisms

Keywords: PDE، فسفودی استراز; CV, circumvallate papillae; GCT, granular convoluted tubule; GPCR, G protein coupled receptors; IP1, inositol monophosphate; IP3, inositol triphosphate; PDE, phosphodiesterase; PKA, protein kinase A; PLCβ2, phospholipase Cβ2; SMG, submandibular glands; T2

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Dihydroartemisinin can inhibit calmodulin, calmodulin-dependent phosphodiesterase activity and stimulate cellular immune responses

Keywords: PDE، فسفودی استراز; CaM, calmodulin; ART, artemisinin; DHA, dihydroartemisinin; PDE, phosphodiesterase; DTH, delayed type hypersensitivityArtemisinin; Calmodulin; Dihydroartemisinin; Phosphodiesterase

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

2′,3′-cAMP hydrolysis by metal-dependent phosphodiesterases containing DHH, EAL, and HD domains is non-specific: Implications for PDE screening

Keywords: PDE، فسفودی استراز; bis-pNPP, bis(p-nitrophenyl)phosphate; AP, alkaline phosphatase; CNPase, 2′,3′-cyclic-nucleotide 3′-phosphodiesterase; PDE, phosphodiesterase; PPT, phosphopantetheinyl; HPLC, high performance liquid chromatography2′,3′-cAMP; Phosphodiesterase; Hydrolysis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells

Keywords: PDE، فسفودی استراز; cAMP, cyclic adenosine monophosphate; Treg, regulatory T cells; Tcon, conventional T cells; PDE, phosphodiesterase; AC, adenylyl cyclase; IL-2, interleukin-2; mAbs, monoclonal Abs; ddADO, 2′,3′-dideoxy-adenosine; Dip, DipyridamoleCyclic adenosine monophos

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

KMUP-1 attenuates serum deprivation-induced neurotoxicity in SH-SY5Y cells: Roles of PKG, PI3K/Akt and Bcl-2/Bax pathways

Keywords: PDE، فسفودی استراز; BDNF, brain-derived neurotrophic factor; cGMP, cyclic guanosine monophosphate; CREB, cAMP response element-binding protein; nNOS, neuronal nitric oxide synthase; PDE, phosphodiesterase; PI3K, phosphatidylinositol 3-kinase; PKG, cGMP-dependent protein kina

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Structural Insight into the Mechanism of c-di-GMP Hydrolysis by EAL Domain Phosphodiesterases

Keywords: PDE، فسفودی استراز; c-di-GMP, cyclic diguanylate; PDE, phosphodiesterase; PDB, Protein Data Bank; TIM, triosephosphate isomerase; bis-p-NPP, bis-para-nitrophenyl phosphate; SAD, single-wavelength anomalous diffraction; Me1, metal ion-1; Me2, metal ion-2; water-1, catalytic w

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2010 سفارش ترجمه

Regulation of AMP-activated protein kinase by cAMP in adipocytes: Roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis

Keywords: PDE، فسفودی استراز; PDE, phosphodiesterase; cAMP, cyclic AMP; Epac, exchange proteins directly activated by cAMP; AMPK, AMP-activated protein kinase; PKA, protein kinase A; PKB, protein kinase B; ACC, acetyl CoA carboxylase; ISO, isoproterenol; INS, insulinPDE3B; PDE4; Epac;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells

Keywords: PDE، فسفودی استراز; EPA, eicosapentaenoic acid; ABCA1, ATP-binding cassette transporter A1; RCT, reverse cholesterol transport; FATP, fatty acid transfer protein; ACS, acyl-CoA synthetase; AC, adenyl cyclase; PDE, phosphodiesterase; cAMP, cyclic AMP; PKA, protein kinase A; d

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway

Keywords: PDE، فسفودی استراز; ET-1, Endothelin-1; NO, nitric oxide; ROCK, Rho-associated coiled coil containing kinase; MAPK, mitogen-activated protein kinase; NOS, nitric oxide synthase; PDE, phosphodiesterase; SNP, sodium nitroprusside; SNAP, S-nitroso-n-acetylpenicillamine; SRF, se

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Crystal Structure of the IrrE Protein, a Central Regulator of DNA Damage Repair in Deinococcaceae

Keywords: PDE، فسفودی استراز; HTH, helix-turn-helix; Dcp, dipeptidyl carboxypeptidase; PDE, phosphodiesterase; DLS, dynamic light scattering; RDRM, radiation/desiccation response motifIrrE; Deinococcus; gene regulation; radiotolerance; zinc

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Role of a differentially expressed cAMP phosphodiesterase in regulating the induction of resistance against oxidative damage in Leishmania donovani

Keywords: PDE، فسفودی استراز; 8-BrcAMP, 8-bromo-cAMP; pCPTcAMP, parachlorophenylthio-cAMP; PDE, phosphodiesterase; FCS, fetal calf serum; IBMX, 3-isobutyl-1-methylxanthine, ODC, ornithine decarboxylase; ORF, open reading frame; PBS, phosphate-buffered saline; ROS, reactive oxygen spec

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Determinants for the Activation and Autoinhibition of the Diguanylate Cyclase Response Regulator WspR

Keywords: PDE، فسفودی استراز; c-di-GMP, bis-(3′–5′)-cyclic dimeric guanosine monophosphate; PDE, phosphodiesterase; REC, receiver domain; SEC, size-exclusion chromatography; I-site, inhibitory site; PDB, Protein Data Bank; CR, Congo red; CHESS, Cornell High Energy Synchrotron Sourcesi

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2009 سفارش ترجمه

Feasibility of using a surface plasmon resonance-based biosensor to detect and quantify yessotoxin

Keywords: PDE، فسفودی استراز; SPR, surface plasmon resonance; DSP, diarrhetic shellfish poisoning; YTX, yessotoxin; PDE, phosphodiesterase; DMSO, dimethyl sulfoxide; PBS, phosphate-buffered saline; HBS-EP, hepes buffered saline; NHS, N-hydroxysuccimide; EDC, ethyl-N-(dimethylaminoprop

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor

Keywords: PDE، فسفودی استراز; COX, cyclooxygenase; NO, nitric oxide; PDE, phosphodiesterase; PKG, cyclic GMP-dependent protein kinase.Nitrate tolerance; Nitroglycerin; Phosphodiesterase; Aorta (rat)

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Salvage of Sildenafil Failures With Bremelanotide: A Randomized, Double-Blind, Placebo Controlled Study

Keywords: PDE، فسفودی استراز; receptors; melanocortin; erectile dysfunction; drug therapy; sildenafil; PT-141ED, erectile dysfunction; IIEF, International Index of Erectile Function; MC, melanocortin; PDE, phosphodiesterase

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging

Keywords: PDE، فسفودی استراز; cGMP, guanosine 3',5'-cyclic monophosphate; DMSO, dimethylsulfoxide; PBS, phosphate buffer saline; MRP, mulitidrug resistance protein; NOS, nitric oxide synthase; NMDA, N-methyl-d-aspartate; PDE, phosphodiesterase; PKG, protein kinaseG; sGC, soluble guany

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Involvement of cyclic GMP in phytochrome-controlled flowering of Pharbitis nil

Keywords: PDE، فسفودی استراز; cGMP; Flowering; Pharbitis nil; Photoperiodic induction; PhytochromecGMP, guanosine-3′:5′-cyclic monophosphate; GC, guanylate cyclase; IBMX, 3-isobutyl-1-methylxanthine; PDE, phosphodiesterase; SNP, sodium nitroprusside

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Role of intracellular cAMP in differentiation-coupled induction of resistance against oxidative damage in Leishmaniadonovani

Keywords: PDE، فسفودی استراز; pCPTcAMP, para-chlorophenylthio cAMP; DDA, dideoxyadenosine; H89, N-[2-((p-bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide; PDE, phosphodiesterase; FCS, fetal calf serum; PKA, protein kinase A; IBMX, 3-isobutyl-1-methylxanthine; ORF, open reading fra

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2008 سفارش ترجمه

Isolated Septal Fibrosis or Hematoma—Atypical Peyronie’s Disease?

Keywords: PDE، فسفودی استراز; penis; penile induration; ultrasonography; wounds and injuries; pentoxifyllineCSL, circumscribed septal lesion; ED, erectile dysfunction; PD, Peyronie’s disease; PDE, phosphodiesterase

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Involvement of l-arginine–nitric oxide–cyclic guanosine monophosphate pathway in the antidepressant-like effect of venlafaxine in mice

Keywords: PDE، فسفودی استراز; AMP, Adenosine monophosphate; cGMP, Cyclic guanosine monophosphate; FST, Forced swim test; NET, Norepinephrine transporter; NO, Nitric oxide; NOS, Nitric oxide synthase; PDE, Phosphodiesterase; SERT, Serotonin transporter; sGC, soluble guanylate cyclaseCy

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Novel mechanisms of the regulation of Protein kinase B in adipocytes; implications for Protein kinase A, Epac, Phosphodiesterases 3 and 4

Keywords: PDE، فسفودی استراز; PKB, protein kinase B; PKA, protein kinase A; Epacs, Exchange proteins directly activated by cAMP; PDE, phosphodiesterase; ACC, acetyl-CoA carboxylaseInsulin; PI3K; Phosphodiesterase inhibitor; cAMP; Adipocyte; Lipogenesis; ACC

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Lipoic acid stimulates cAMP production in T lymphocytes and NK cells

Keywords: PDE، فسفودی استراز; AC, adenylyl cyclase; cAMP, cyclic AMP; DHLA, dihydrolipoic acid; DMLA, dimethyl lipoic acid; IBMX, isobutylmethylxanthine; LA, lipoic acid; LPM, lipoamide (DL 6,8-thioctic acid amide); NK, natural killer cell; PDE, phosphodiesterase; PGE2, prostaglandin

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Various effects of antidepressant drugs on bone microarchitectecture, mechanical properties and bone remodeling

Keywords: PDE، فسفودی استراز; SSRIs, selective serotonin-reuptake inhibitors; PDE, phosphodiesterase; BV/TV, %, trabecular bone volume; Tb.N, trabecular number; Tb.Sp, μm, trabecular separation; Tb.Th, μm, trabecular thickness; DA, degree of anisotropyAntidepressant treatment; PDE inh

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity

Keywords: PDE، فسفودی استراز; prepulse inhibition; schizophrenia; animal model; psychopharmacology; novel targets; phosphodiesterase inhibitorANOVA, analysis of variance; bg, background; EPS, extrapyramidal side effects; PDE, phosphodiesterase; PPI, prepulse inhibition of acoustic sta

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

A Cell-Based, High-Throughput Screen for Small Molecule Regulators of Hepatitis C Virus Replication

Keywords: PDE، فسفودی استراز; HCV, hepatitis C virus; HMG-CoA, hydroxyl-methyl-glutaryl coenzyme A; HTS, high-throughput screening; PDE, phosphodiesterase; PEG-IFN, pegylated interferon; S/B, signal-to-background; SVR, sustained virologic response

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages

Keywords: PDE، فسفودی استراز; EHNA, erythro-9-(2-hydroxy-3-nonyl)adenine; GC, guanylyl cyclase; HBSS, Hank's balanced salt solution; IBMX, 3-isobutyl-1-methylxanthine; PDE, phosphodiesterase; PEM, peritoneal exudate macrophage; PMSF, phenylmethylsulfonyl fluoride; RPM, resident perito

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Involvement of a Go-type G-protein coupled to guanylate cyclase in the phototransduction cGMP cascade of molluscan simple photoreceptors

Keywords: PDE، فسفودی استراز; 4-AP, 4-aminopyridine; l-DIL, l-cis-diltiazem; PDE, phosphodiesterase; MB, methylene blue; NEM, N-ethylmaleimide; GC, guanylate cyclase; C16BAC, benzalkonium chloride (C16H33N[CH3]2-C7H7Cl)Molluscan simple photoreceptors; Nonvisual photoreceptive modality

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

A Randomized, Placebo-Controlled, Phase II Study of Tetomilast in Active Ulcerative Colitis

Keywords: PDE، فسفودی استراز; DAI, Disease Activity Index; FS, flexible sigmoidoscopy; IBDQ, Inflammatory Bowel Disease Questionnaire; LOCF, last observation carried forward; PDE, phosphodiesterase; RB, rectal bleeding

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه