Keywords: مهار کننده های PDE4; Toxoplasma gondii; PDE4 inhibitors; Rolipram; Cytokines; Mice
مقالات ISI مهار کننده های PDE4 (ترجمه نشده)
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Role of efflux transporters in the absorption, distribution and elimination in rodents of a novel PDE4 inhibitor, CHF6001
Keywords: مهار کننده های PDE4; ADME; absorption, distribution, metabolism and excretion; AUC0-t(last); area under the concentration-time curve up to the last measurable concentration; AUCinf; area under the concentration-time curve up to infinity; AUCÏ; area under the concentration-ti
Design and synthesis of 4,5,6,7âtetrahydroâ1Hâ1,2âdiazepinâ7âone derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors
Keywords: مهار کننده های PDE4; Phosphodiesterase 4; PDE4 inhibitors; Diazepinone derivatives; Compound library;
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment
Keywords: مهار کننده های PDE4; PDE4D inhibitors; cAMP enhancers; Memory behavior test; Pharmacokinetic analyses; Molecular dynamics simulation; In silico ADMET properties; AD; Alzheimer Disease; cAMP; cyclic adenosine monophosphate; CR3; conserved region 3; CREB; cAMP response element-
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors
Keywords: مهار کننده های PDE4; AD; Alzheimer disease; cAMP; cyclic adenosine monophosphate; CREB; cAMP response element-binding protein; cGMP; cyclic guanosine monophosphate; OLT; object location test; ORT; object recognition test; PDE; phosphodiesterase; PDE4Is; PDE4 inhibitors; PTC;
Novel Roflumilast analogs as soft PDE4 inhibitors
Keywords: مهار کننده های PDE4; PDE4 inhibitors; Soft drug; SAR; Esterase; COPD
Identification of 2,3-disubstituted pyridines as potent, non-emetic PDE4 inhibitors
Keywords: مهار کننده های PDE4; Phosphodiesterase 4; PDE4 inhibitors; 2,3-Disubstituted pyridine; Structure activity relationship; Anti-inflammatory agent
Application of a phosphodiesterase-4 (PDE4) inhibitor to abort chronic toxoplasmosis and to mitigate consequential pathological changes
Keywords: مهار کننده های PDE4; Toxoplasma gondii; PDE4 inhibitors; Rolipram; cAMP; TNF-α; Histopathology
Identification of 2,3-disubstituted pyridines as potent, orally active PDE4 inhibitors
Keywords: مهار کننده های PDE4; Phosphodiesterase 4; PDE4 inhibitors; 2,3-Disubstituted pyridine; Structure-activity relationship; Anti-inflammatory agent;
Discovery of novel 1,4-dihydropyridine-based PDE4 inhibitors
Keywords: مهار کننده های PDE4; Dihydropyridine scaffold; PDE4 inhibitors; Docking; X-ray crystallography
Phosphodiesterase inhibitors. Part 1: Synthesis and structure–activity relationships of pyrazolopyridine–pyridazinone PDE inhibitors developed from ibudilast
Keywords: مهار کننده های PDE4; Cyclic 3′,5′-nucleotide phosphodiesterase (PDE); Ibudilast; PDE3 inhibitors; PDE4 inhibitors; Respiratory disease
Phosphodiesterase inhibitors. Part 2: Design, synthesis, and structure-activity relationships of dual PDE3/4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory and bronchodilatory activity
Keywords: مهار کننده های PDE4; Cyclic 3â²,5â²-nucleotide phosphodiesterase (PDE); Ibudilast; PDE3 inhibitors; PDE4 inhibitors; Respiratory disease;
Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment
Keywords: مهار کننده های PDE4; MK-0952; PDE4 inhibitors; Mild cognitive impairment
Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity
Keywords: مهار کننده های PDE4; Pyrazoles; Pyrazolo[3,4-d]pyridazinones; PDE4 inhibitors; Structure–activity relationship; Molecular modeling
Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration
Keywords: مهار کننده های PDE4; PDE4 inhibitors; SAR; Crystallography; Quinoline
Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors
Keywords: مهار کننده های PDE4; PDE4 inhibitors; SAR; Crystallography; Pyrazolopyridine
The novel phosphodiesterase 4 inhibitor, CI-1044, inhibits LPS-induced TNF-α production in whole blood from COPD patients
Keywords: مهار کننده های PDE4; PDE4 inhibitors; Inflammation; COPD; Human whole blood;
Synthesis, biological evaluation and molecular modelling studies on benzothiadiazine derivatives as PDE4 selective inhibitors
Keywords: مهار کننده های PDE4; Benzothiadiazine; PDE4 inhibitors; Antioxidant; Chronic inflammatory diseases;
Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation
Keywords: مهار کننده های PDE4; B-CLL; B cell chronic lymphocytic leukemia; PDE4; type 4 cAMP phosphodiesterase; Glucocorticoid therapy; B-CLL; PDE4 inhibitors; cAMP; PKA; GRE;