
COX inhibitors Indomethacin and Sulindac derivatives as antiproliferative agents: Synthesis, biological evaluation, and mechanism investigation
Keywords: COX inhibitor; Indomethacin; Sulindac; Anti-cancer; Tubulin inhibitorCOX, Cyclooxygenase; NSAIDs, non-steroidal anti-inflammatory drugs; PDK, phosphoinositide-dependent kinase; Hsp27, heat shock protein 27; Wnt, “Wnt” was created from a combination of the