دانلود مقالات ISI درباره Peptidomimetics + ترجمه فارسی

Synthesis of self-assembling arylopeptoid bearing hydrophilic polymer on the basis of soluble polymer-supported liquid-phase synthesis

Keywords: Self-assembly; Peptidomimetics; Oligomer; Polymer-supported synthesis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents

Keywords: Dual action compounds; Smac mimetics; Zinc chelation; Apoptosis; Peptidomimetics;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

1,2,3-Triazole-based inhibitors of Porphyromonas gingivalis adherence to oral streptococci and biofilm formation

Keywords: Azides; Biofilms; Click chemistry; Oxazoles; Peptidomimetics;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

An expedient synthesis of non-racemic N-alkylated pyrrolidin-2,5-diones and piperidin-2,6-diones as peptidomimetics

Keywords: Peptidomimetics; N-Alkylation; Piperidin-2,6-dione;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71

Keywords: HFMD; hand, foot and mouth disease; 3Cpro; 3C proteinase; EV71; enterovirus 71; HRV; human rhinovirus; NMR; nuclear magnetic resonance; RP-HPLC; reverse phase-high pressure liquid chromatography; TFA; trifluoroacetic acid; LC; liquid chromatography; MS; m

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Cyclic RGD peptidomimetics containing 4- and 5-amino-cyclopropane pipecolic acid (CPA) templates as dual αVβ3 and α5β1 integrin ligands

Keywords: Synthesis; 2,3-Methanopipecolic acids; Peptidomimetics; Ligands; Integrins

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Carbohydrate-based peptidomimetics targeting neuropilin-1: Synthesis, molecular docking study and in vitro biological activities

Keywords: MRI; magnetic resonance imaging; AKT; serine/threonine protein kinase; ERK1/2; extracellular signal-regulated protein kinases 1 and 2; Neuropilin-1; VEGF; Carbohydrate scaffolds; Peptidomimetics; Molecular modeling;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and antimicrobial activity of small cationic amphipathic aminobenzamide marine natural product mimics and evaluation of relevance against clinical isolates including ESBL-CARBA producing multi-resistant bacteria

Keywords: ESBL-CARBA; Aminobenzamides; Antibacterial; Antimicrobial; Marine natural product mimics; Multi-resistant bacteria; Peptidomimetics;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Improved in vitro evaluation of novel antimicrobials: potential synergy between human plasma and antibacterial peptidomimetics, AMPs and antibiotics against human pathogenic bacteria

Keywords: Antimicrobial peptide; Peptidomimetics; Antibiotics; Plasma; Synergy

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis and anti-HIV-1 evaluation of hydrazide-based peptidomimetics as selective gelatinase inhibitors

Keywords: Hydrazide derivatives; Quinoxalinone; Selective gelatinase inhibitors; Peptidomimetics; Anti-HIV activity

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Development of the first internally-quenched fluorescent substrates of human cathepsin C: The application in the enzyme detection in biological samples

Keywords: FRET substrates; cysteine proteases; Cathepsin C; Peptidomimetics;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

N-alkylated dipeptide amides and related structures as imitations of the melanocortins’ active core

Keywords: Melanocortins; Peptidomimetics; Peptoid–peptide hybrids; Solid phase organic synthesis; Structure–activity; QSAR; NMR

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and characterization of gadolinium-Peptidomimetic complex as an αvβ3 integrin targeted MR contrast agent

Keywords: Integrin αvβ3; Gadolinium; DOTA; Peptidomimetics; Antagonist; Gd-153; MR imaging;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

N-Substituted arylsulfonamide building blocks as alternative submonomers for peptoid synthesis

Keywords: Peptoids; Peptidomimetics; Solid-phase synthesis; Nitrobenzenesulfonamides;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Activity of lipo-cyclic γ-AApeptides against biofilms of Staphylococcus epidermidis and Pseudomonas aeruginosa

Keywords: Biofilm prevention; Peptidomimetics; Antimicrobial;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Oxazoles for click chemistry II: synthesis of extended heterocyclic scaffolds

Keywords: Oxazoles; Azides; Click chemistry; Peptidomimetics; Biofilms;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Design, synthesis and aphicidal activity of N-terminal modified insect kinin analogs

Keywords: Insect kinins; N-terminal modified; Peptidomimetics; Aphicidal activity; Insecticides;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Microwave (MW) irradiated Ugi four-component reaction (Ugi-4CR): Expedited synthesis of steroid–amino acid conjugates – A novel class of hybrid compounds

Keywords: Steroid–amino acid conjugates; Peptidomimetics; Artificial enzymes; Phospholipid membranes; Multi component reactions; Ugi-4CR

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Recent progress of sugar amino acids: Synthetic strategies and applications as glycomimetics and peptidomimetics

Keywords: Sugar amino acids; Synthetic strategy; Glycomimetics; Peptidomimetics

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

Keywords: Coronavirus; 3CLpro; Feline infectious peritonitis; Structure-based drug design; Peptidomimetics;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The fluoroalkene motif as a surrogate of the amide bond: syntheses of AA-Ψ[(Z) and (E)-CFCH]-Pro pseudodipeptides and an Enalapril analogue

Keywords: Fluoroalkene; Proline; Peptidomimetics;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Mimicking bone extracellular matrix: Integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium

Keywords: Peptidomimetics; Integrins; Titanium; Functionalization; Osteointegration;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

In silico studies, synthesis and binding evaluation of substituted 2-pyrrolidinones as peptidomimetics of RGD tripeptide sequence

Keywords: Peptidomimetics; RGD; Integrin; Docking; Synthesis; Binding

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of a series of novel compounds with moderate anti-hepatitis C virus NS3 protease activity in vitro

Keywords: HCV; Protease inhibitors; Peptidomimetics; Triazole; Acylsulfonamide;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2015 سفارش ترجمه

Tetrahedron report number 1078Amino acid chlorides: a journey from instability and racemization toward broader utility in organic synthesis including peptides and their mimetics

Keywords: Amino acid chlorides; Sterically hindered coupling; Peptides; Peptidomimetics; Heterocycles;

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2015 سفارش ترجمه

New paradigm of an old target: An update on structural biology and current progress in drug design towards plasmepsin II

Keywords: Malaria; Plasmepsin II; Aspartic protease; Peptidomimetics; Protease inhibitor; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2015 سفارش ترجمه

Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes

Keywords: Peptidomimetics; Anti-inflammatory; Anti-hyperalgesic; COX-2; 5-LOX inhibitors; ACN; acetonitrile; COX; cyclooxygenase; LOX; lipoxygenase; SAID; steroidal anti-inflammatory drugs; NSAID; non-steroidal anti-inflammatory drugs; COXIBS; selective cyclooxygen

دانلود رایگان متن کامل مقاله ISI 116 صفحه سال انتشار : 2015 سفارش ترجمه

βγ-fused turn structures in sugar amino acid (SAA) containing cyclic tetrapeptides with α3δ architecture

Keywords: Macrocycles; Peptidomimetics; βγ-fused turns; Conformational study; Molecular dynamics;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

SPION-Smac mimetic nano-conjugates: Putative pro-apoptotic agents in oncology

Keywords: SPION nanoparticles; Smac mimetics; Pro-apoptotics; Oncology; Peptidomimetics

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Second generation, arginine-rich (R-X′-R)4-type cell-penetrating α-ω-α-peptides with constrained, chiral ω-amino acids (X′) for enhanced cargo delivery into cells

Keywords: Cell-penetrating peptide; Constrained chiral amino acid; Peptidomimetics; (R-X-R)-motif; α-ω-α-Peptide;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Chameleonic reactivity of α-amino nitrile-derived ureas. Synthesis of highly functionalized imidazolidin-2-one and imidazolidine-2,4-dione derivatives

Keywords: Peptidomimetics; Tautomerism; α-Amino nitriles; Imidazolidine-2-one derivatives; Hydantoin derivatives;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Ala-7, His-10 and Arg-12 are crucial amino acids for activity of a synthetically engineered μ-conotoxin

Keywords: NaV-channel; voltage-gated sodium channel; CD; circular dichroism; (μ-)Conotoxin; Voltage-gated sodium channel; Midi R2; Circular dichroism; Cone snail; Peptidomimetics;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Structure–activity relationships of sugar-based peptidomimetics as modulators of amyloid β-peptide early oligomerization and fibrillization

Keywords: Amyloid β-peptide; Alzheimer's disease; Oligomers; Peptidomimetics; Glycopeptides; Capillary electrophoresis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Peptidomimetics with tunable tertiary amide bond containing substituted β-proline and β-homoproline

Keywords: Peptidomimetics; β-Proline and β-homoproline; cis-trans Isomerization; 2D-NMR; DFT;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Small molecule mimetics of an interferon-α receptor interacting domain

Keywords: Interferon; Peptidomimetics; IFN-α receptor;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis and assay of retro-α4β1 integrin-targeting motifs

Keywords: VLA-4 ligands; Scintillation proximity assay; Cell adhesion inhibition; Peptidomimetics; Retro sequences; β2-Proline; Diphenylurea; IsoaspartateVCAM, vascular cell adhesion molecule; ECM, extracellular matrix; VT, vitronectin; FN, fibronectin; phg, d-phen

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Short analogs and mimetics of human urocortin 3 display antidepressant effects in vivo

Keywords: Depressive disorder; Urocortin 3 fragments; Antidepressants; Peptidomimetics; Azapeptides

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis of truncated analogues of preptin-(1–16), and investigation of their ability to stimulate osteoblast proliferation

Keywords: Preptin; Peptidomimetics; Osteoporosis; Ring closing metathesis (RCM)

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Targeting integrins αvβ3 and α5β1 with new β-lactam derivatives

Keywords: Lactams; Integrins; Azetidinones; Peptidomimetics; Agonists; Cell adhesion

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Recent approaches to medicinal chemistry and therapeutic potential of dipeptidyl peptidase-4 (DPP-4) inhibitors

Keywords: Diabetes; Dipeptidyl peptidase-4; Glucagon like peptide (GLP)-1; Non-peptidomimetics; Peptidomimetics;

دانلود رایگان متن کامل مقاله ISI 140 صفحه سال انتشار : 2014 سفارش ترجمه

Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade

Keywords: Peptidomimetics; Ugi reaction; Multi-component reaction; N-acyliminium ion; Heterocycles;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Surprising behavior of NXO-peptides toward the lithium hydroxide solvolysis

Keywords: Peptidomimetics; NXO-building blocks; l-Phenylalanine; Modified amino acids; Rearrangement;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Application of the rule of shielding in the design of novel fluorinated structural motifs and peptidomimetics

Keywords: Fluorine; NMR; Peptidomimetics; Pentafluorosulfanyl; Fluorinated fragments;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Solid phase synthesis of Smac/DIABLO-derived peptides using a 'Safety-Catch' resin: Identification of potent XIAP BIR3 antagonists

Keywords: SPPS; Safety-Catch resin; Peptidomimetics; Smac/DIABLO; XIAP BIR3; Cancer resistance; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Chirality of the molecular assembly determined by intra-/inter-N-H⋯O hydrogen bonding in doubly substituted N-octanoylglyoxylic amides

Keywords: Glyoxylamides; N-Acylisatins; Assembly; Peptidomimetics;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies

Keywords: SARS; SARS-CoV 3CLpro; Dipeptide; Peptidomimetics; Cysteine protease inhibitors;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

RANKL targeted peptides inhibit osteoclastogenesis and attenuate adjuvant induced arthritis by inhibiting NF-κB activation and down regulating inflammatory cytokines

Keywords: RANK; RANKL; Arthritis; NF-κB; Osteoprotegrin; Peptidomimetics;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Highly functionalized 2-oxopiperazine-based peptidomimetics: An approach to PAR1 antagonists

Keywords: PAR1 antagonists; Peptidomimetics; 2-Oxopiperazines; α-Amino nitriles; Platelet antiaggregant activity; Cytotoxicity;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases

Keywords: Peptidomimetics; Coronavirus; X-ray crystallography; Protease

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Selectivity in the potentiation of antibacterial activity of α-peptide/β-peptoid peptidomimetics and antimicrobial peptides by human blood plasma

Keywords: Peptidomimetics; Plasma; Synergy; Escherichia coli; Staphylococcus aureus

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه