Keywords: Pgp، P-glycoprotein; PVC, polyvinyl chloride; TBT, tributyltin; DBT, dibutyltin; IC50, half inhibitory concentration; MDR, multidrug resistance; Pgp, P-glycoprotein; PEG, polyethylene glycol; GI50, growth inhibition 50%; ID50, the half-inhibition dose; NSAIDs, non-steroidal a
مقالات ISI Pgp، P-glycoprotein (ترجمه نشده)
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Keywords: Pgp، P-glycoprotein; Chalcone; Metal complex; Antiobesity; Antioxidant; CytotoxicityOE, oleoyl estrone; ROS, reactive oxygen species; SD, spargue–dawley; Pgp, P-glycoprotein; BCRP, breast cancer resistant protein; MRP1, multidrug resistance-associated protein 1; TGA, thermal
ABC-B transporter genes in Dirofilaria immitis
Keywords: Pgp، P-glycoprotein; Dirofilaria immitis; P-glycoprotein; Genetic identificationML, macrocyclic lactones; LOE, loss of efficacy; Kb, kilobase; Tm, melting temperature; TM, transmembrane domain; Pgp, P-glycoprotein; ATP, adenosine triphosphate; IVM, ivermectin
Quercetin–POM (pivaloxymethyl) conjugates: Modulatory activity for P-glycoprotein-based multidrug resistance
Keywords: Pgp، P-glycoprotein; Quercetin; Pivaloxymethyl; Multidrug resistance (MDR); P-glycoprotein (Pgp); ModulatorMDR, multidrug resistance; POM, pivaloxymethyl; Pgp, P-glycoprotein; PBS, phosphate buffered saline; DMSO, dimethylsulfoxide; RPMI-1640 medium, Roswell Park Memorial Ins
Insights in the chemical components of liposomes responsible for P-glycoprotein inhibition
Keywords: Pgp، P-glycoprotein; Pgp, P-glycoprotein; MRPs, multidrug-resistance related proteins; BCRP, breast cancer resistance protein; PEG, polyethylene glycol; DPPG, 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-glycerol; DOTAP, 1,2-dioleoyloxy-3-trimethylammoniumpropanchloride; DPPC, 1,
Hydroxypropyl-Sulfobutyl-β-Cyclodextrin Improves the Oral Bioavailability of Edaravone by Modulating Drug Efflux Pump of Enterocytes
Keywords: Pgp، P-glycoprotein; cyclodextrins; edaravone; bioavailability; permeability; P-glycoprotein; lipid raft; Caco-2 cells; pharamcokinetics; solubility; CDs, cyclodextrins; HP-SBE-βCD, hydroxypropylsulfobutyl-β-cyclodextrin; HP-βCD, hydroxypropyl-β-cyclodextrin; SBE-βCD, su
MDR-selective microbial-based therapy: A novel approach to cancer treatment
Keywords: Pgp، P-glycoprotein; MDR, multidrug resistance; MBT, MDR-selective bacterial therapy; BCG, Bacillus Calmete–Guerin; MRP, Multidrug resistance-associated protein; Pgp, P-glycoprotein; MIC, minimum inhibitory concentration; MHC, major histocompatibility complex; CADD, chlamydia
PXR-mediated P-glycoprotein induction by small molecule tyrosine kinase inhibitors
Keywords: Pgp، P-glycoprotein; ABC, ATP-binding cassette; ATP, adenosine triphosphate; DMSO, dimethylsulfoxide; MDCKII, Madin Darby canine kidney II – MDCKII; MDR1, multidrug resistance protein 1; NR, nuclear receptor; PGP, P-glycoprotein; PXR, pregnane X receptor; siRNA, short inhibit
Effect of repeated dosing on rifampin exposure in BALB/c mice
Keywords: Pgp، P-glycoprotein; CYP3A, cytochrome P450 3A; Pgp, P-glycoprotein; PXR, pregnane X receptor; TB, tuberculosisMouse; Rifampin; CYP3A; Pgp; Induction
Mechanistic basis for unexpected bioavailability enhancement of polyelectrolyte complexes incorporating BCS class III drugs and carrageenans
Keywords: Pgp، P-glycoprotein; SDS, sodium dodecyl sulfate; TPGS, tocopheryl polyethylene glycol succinate; PGP, P-Glycoprotein; TJs, tight junctions; API, active pharmaceutical ingredient; PECs, polyelectrolyte complexes; KBR, Krebs-Ringer-Bicarbonate-buffer. pH 7.4; R, transsegmental
Synthesis of 5,7-disubstituted-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as microtubule inhibitors
Keywords: Pgp، P-glycoprotein; MT, microtubule; MDR, multiple drug resistance; Pgp, P-glycoprotein; MRP, multidrug-resistance proteins; TLC, thin layer chromatography; NMR, nuclear magnetic resonance; HRMS, high resolution mass spectraPyrrolo[2,3-d]pyrimidines; Microtubule inhibitors;
PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation
Keywords: Pgp، P-glycoprotein; BBB, blood–brain barrier; BCSFB, blood–CSF-barrier; CNS, central nervous system; CSF, cerebrospinal fluid; ER, efflux ratio; PD, pharmacodynamic; Pgp, P-glycoprotein; PK, pharmacokinetic; IVIVC, in vitro–in vivo correlationsCerebrospinal fluid; P-glycopro
MDR1 single nucleotide polymorphism C3435T in Turkish patients with non-small-cell lung cancer
Keywords: Pgp، P-glycoprotein; ABCB1, adenosine triphosphate (ATP); ATP, adenosine triphosphate; CR, complete response; HR, hazard ratio; MDR, multi-drug resistance; NSCLC, non small cell lung cancer; PCR, polymerase chain reaction; PD, progressive disease; Pgp, P-glycoprotein; PR, par
Improving the prediction of the brain disposition for orally administered drugs using BDDCS
Keywords: Pgp، P-glycoprotein; BDDCS, Biopharmaceutics drug disposition classification system; BBB, Blood–brain barrier; Pgp, P-glycoprotein; CNS, Central nervous systemBrain disposition; Data mining; Drug discovery; Rules of thumb
Therapeutics, imaging and toxicity of nanomaterials in the central nervous system
Keywords: Pgp، P-glycoprotein; CNS, central nervous system; BBB, blood brain barrier; CMT, carrier mediated transcytosis; AMT, absorptive mediated transcytosis; RTM, receptor mediated transcytosis; Pgp, P-glycoprotein; SC, spinal cord; EEG, electroencephalography; MEG, magnetoencephalo
Increasing oxime efficacy by blood–brain barrier modulation
Keywords: Pgp، P-glycoprotein; OP, organophosphate; BBB, blood–brain barrier; Pgp, p-glycoprotein; AChE, acetylcholinesterase; BCRP, breast cancer resistance protein (BCRP); TQD, tariquidarNerve agent; Tariquidar; HI6; Seizures; P-glycoprotein
Darunavir/ritonavir and raltegravir coadministered in routine clinical practice: Potential role for an unexpected drug interaction
Keywords: Pgp، P-glycoprotein; Ctrough, trough concentration; CVinter, inter-individual coefficient of variation; CVintra, intra-individual coefficient of variation; SD, standard deviation; CI, confidence intervals; IQR, interquartile range; Pgp, P-glycoprotein; DRV, darunavir; RAL, ra
A LDL-masked liposomal-doxorubicin reverses drug resistance in human cancer cells
Keywords: Pgp، P-glycoprotein; LDL, low density lipoprotein; LDLR, low density lipoprotein receptor; Pgp, P-glycoprotein; MDR, multidrug resistance; ABC, ATP binding cassette; NO, nitric oxide; HMGCR, 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Lipodox, liposomal doxorubicin; apo-
Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors
Keywords: Pgp، P-glycoprotein; IP, inflection point; sAPP_NF, cell based assay utilizing NF mutation for sAPP. See Ref. 15; PGP, P-glycoprotein; Papp, apparent permeability value; PB, protein binding; IP, dosing: intraperitoneal dosing; Mpk, milligrams of compound per kilogram of anima
Pgp inhibition by UIC2 antibody can be followed in vitro by using tumor-diagnostic radiotracers, 99mTc-MIBI and 18FDG
Keywords: Pgp، P-glycoprotein; Pgp, P-glycoprotein; mAb, monoclonal antibody; mdr, multidrug resistance; CSA, cyclosporine A; 99mTc-MIBI, 99mTc-hexakis-2-methoxybutylisonitrille; 18FDG, 2-[18F]fluoro-2-deoxy-d-glucose; R123, rhodamine 123; DNR, daunorubicin; Pacl, paclitaxel; Bepr, bep
Schistosoma mansoni express higher levels of multidrug resistance-associated protein 1 (SmMRP1) in juvenile worms and in response to praziquantel
Keywords: Pgp، P-glycoprotein; MDR, multidrug resistance; MRP, multidrug resistance-associated protein; PZQ, praziquantel; Pgp, P-glycoprotein; ABC, ATP-binding cassetteSchistosoma mansoni; Multidrug resistance-associated protein; Multidrug resistance; Praziquantel; ABC transporter; AB
Association of ion-channel genotype and macrocyclic lactone sensitivity traits in Haemonchus contortus
Keywords: Pgp، P-glycoprotein; MOX, moxidectin; IVM, ivermectin; ML, macrocyclic lactone; SA, sodium azide; GABA, gamma amino butyric acid; Pgp, P-glycoprotein; PCR, polymerase chain reactionHaemonchus contortus; Ivermectin; Moxidectin; Larval motility; Adult feeding; Anthelmintic resi
Targeted cytotoxic somatostatin analog AN-162 inhibits growth of human colon carcinomas and increases sensitivity of doxorubicin resistant murine leukemia cells
Keywords: Pgp، P-glycoprotein; SST, somatostatin; DOX, doxorubicin; CRC, colorectal cancer; MDR, multiple drug resistance; MTS, 3-(45-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium; TopII, Topoisomerase II; Pgp, P-glycoprotein; MRP-1, MDR related prot
American ginseng: Potential structure–function relationship in cancer chemoprevention
Keywords: Pgp، P-glycoprotein; COX-2, cyclooxygenase-2; ECs, endothelial cells; IC50, 50% inhibitory concentration; MMP, matrix metalloproteinase; NF-κB, nuclear factor-κB; Pgp, P-glycoprotein; PPD, protopanaxadiol; PPT, protopanaxatriolAmerican ginseng; Panax quinquefolius; Asian gins
Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys
Keywords: Pgp، P-glycoprotein; Pgp, P-glycoprotein; MDR1, multidrug resistance protein; CNS, central nervous system; CSF, cerebral spinal fluid; ISF, interstitial fluid; BBB, blood–brain barrier; BCSFB, blood–CSF barrier; CCSF, compound concentration in CSF; Cup, unbound compound conce
Suppressive effect of tobacco smoke extracts on oral P-glycoprotein function and its impact in smoke-induced insult to oral epidermal cells
Keywords: Pgp، P-glycoprotein; TS, tobacco smoke; Pgp, P-glycoprotein; OEC-M1, oral epidermal carcinoma cell line, Meng-1; CTS, the cyclohexane extract of tobacco smoke; ITS, the isopropanol extract of tobacco smoke; Rh 123, rhodamine 123Tobacco smoke; P-glycoprotein; Oral cell insult
Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1α in human colon cancer cells
Keywords: Pgp، P-glycoprotein; Pgp, P-glycoprotein; HIF-1 α, hypoxia-inducible factor-1α; CaMKII, calmodulin kinase II; BAPTA, 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid; KB-R7943, 2-[2-[4-(4-nitrobenzyloxy) phenyl]ethyl]isothiourea; KN93, 2-[N-(2-hydroxyethyl)]-N-(4-meth
Translational Coupling Controls Expression and Function of the DrrAB Drug Efflux Pump
Keywords: Pgp، P-glycoprotein; Pgp, P-glycoprotein; SD, Shine–Dalgarno; ORF, open reading frame; RBS, ribosome binding sitedrug resistance; ABC transporter assembly; DrrAB; translational coupling; doxorubicin resistance
The role of ATP-binding cassette (ABC) proteins in protozoan parasites
Keywords: Pgp، P-glycoprotein; Pgp, P-glycoprotein; MRP, multidrug resistance-associated protein; MDR, multidrug resistance; ABC, ATP-binding cassetteProtozoan; ATP-binding cassette transporter; ABC; P-glycoprotein; MRP; Resistance
The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood–brain barrier in patients with generalized epilepsy
Keywords: Pgp، P-glycoprotein; AED(s), antiepileptic drug(s); Pgp, P-glycoprotein; BBB, blood–brain barrier; CSF, cerebrospinal fluid; S, serum; PB, phenobarbitalCerebrospinal fluid; Drug resistance; Epilepsy; P-glycoprotein; Phenobarbital; Polymorphism; Genetic
Development of taxane resistance in a panel of human lung cancer cell lines
Keywords: Pgp، P-glycoprotein; SCLC, small cell lung cancer; LCLC, large cell lung cancer; NSCLC, non-small cell lung cancer; H1299, NCI-H1299; H460, NCI-H460; FCS, foetal calf serum; Pgp, P-glycoprotein; MRP-1, multidrug resistance protein 1; 5-FU, 5-fluorouracil; VP-16, etoposide; NS
ABC transporters and the accumulation of imatinib and its active metabolite CGP74588 in rat C6 glioma cells
Keywords: Pgp، P-glycoprotein; ABC, ATP-binding cassette; BBB, blood–brain barrier; Bcrp, breast cancer resistance protein; Mrp, multidrug resistance-associated protein; Pgp, P-glycoprotein; qRT-PCR, real time quantitative reverse transcription-polymerase chain reaction; PDGF, platelet
Enhancing drug absorption using lipids: A case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections
Keywords: Pgp، P-glycoprotein; AmpB, amphotericin B; CSA, cyclosporine A; FZ, Fungizone®; GI, gastrointestinal; PgP, P-glycoprotein; HIV, human immunodeficiency virus; AIDS, autoimmune deficiency syndrome; RBC, red blood cells; SNEDDS, self-nanoemulsification drug delivery system; PEG,
P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus
Keywords: Pgp، P-glycoprotein; IVM, ivermectin; PLP, P-glycoprotein-like protein; OvPLP, Onchocerca volvulus P-glycoprotein-like-protein gene; ABC, ATP binding cassette; Pgp, P-glycoprotein; OvPgp, Onchocerca volvulus P-glycoprotein gene; hsp60, heat shock protein 60; SNP, single nucle
The yeast Pdr5p multidrug transporter: How does it recognize so many substrates?
Keywords: Pgp، P-glycoprotein; ABC, ATP-binding cassette; chl, chloramphenicol; R6g, rhodamine 6G; clo, clotrimazole; MIC, minimum inhibitory concentration; TPCl, tripentyltin chloride; Pgp, P-glycoprotein; trit, tritylimidazole; IAAP, 125iodoarylazidoprazosinYeast multidrug resistance
Reversal of drug resistance in breast carcinoma cells by anti-mdr1 ribozyme regulated by the tumor-specific MUC-1 promoter
Keywords: Pgp، P-glycoprotein; Multidrug resistance; Reversal; Ribozyme; Specific expressionMDR, multidrug resistance; Pgp, p-glycoprotein; EGFP, Enhanced Green Fluorescence Protein
The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding
Keywords: Pgp، P-glycoprotein; ABC, ATP-binding cassette; CFTR, cystic fibrosis transmembrane regulator; NBD, nucleotide-binding domain; Pgp, P-glycoprotein; TM, Transmembrane domainABC transporter; ATP hydrolysis; Nucleotide-binding domain; Homology modeling; Multidrug resistance; Seq
Marked decrease of cyclosporin bioavailability caused by coadministration of ginkgo and onion in rats
Keywords: Pgp، P-glycoprotein; Pgp, P-glycoprotein; CYP, cytochrome P450; T1/2, half-life; AUC0–5 h, area under the blood concentration–time curve from time zero to 5 h; Cmax, the peak blood concentration; Tmax, time to reach Cmax; MRT, mean residence timeCyclosporin; Ginkgo; Onion; In
The ABC of auxin transport: The role of p-glycoproteins in plant development
Keywords: Pgp، P-glycoprotein; PGP, p-glycoprotein; MDR, multidrug resistance; PAT, polar auxin transport; IAA, indole-3-acetic acid; NPA, 1-N-naphthylphthalamic acid; TWD1, TWISTED DWARF1p-Glycoprotein; ABC transporter; Auxin; Multidrug resistance; Plant development
The nitroxide Tempol modulates anthracycline resistance in breast cancer cells
Keywords: Pgp، P-glycoprotein; MDR, multridrug resistance; DOX, doxorubicin; Pgp, P-glycoprotein; MRP, MDR-related protein; TPL, Tempol; WT, wild type; ROS, reactive oxygen species; mAb, monoclonal antibody; NAC, N-acetylcysteine; H2DCF-DA, 2′,7′dichlorodihydrofluorescein diacetate; DM
Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations
Keywords: Pgp، P-glycoprotein; BT, bongkrekic acid; DMEM, Dulbecco's modified Eagle's Medium; GSH, glutathione; GST, glutathione-S-transferase; MRP, multidrug resistance protein; MDR1, multidrug resistance-associated protein; NAC, N-acetyl-cysteine; Pgp, P-glycoprotein; S.E., standard
Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells
Keywords: Pgp، P-glycoprotein; [125I]IAAP, [125I]iodoarylazidoprazosin; MDR, multidrug resistance; Pgp, P-glycoprotein; PI, propidium iodide; Rh-123, rhodamine-123; SDS-PAGE, sodium doedecyl sulphate-polyacrylamide gel electrophoresis; SRB, sulforhodamine BGomisin A; Multidrug resistan
Up-regulation of lactosylceramide synthase in MDR1 overexpressing human liver tumour cells
Keywords: Pgp، P-glycoprotein; ABC, ATP-binding cassette; Cer, ceramide; CSA, cyclosporin A; GlcCer, glucosylceramide; HPTLC, high performance thin layer chromatography; LacCer, lactosylceramide; Pgp, P-glycoprotein; SM, sphingomyelinHepG2; Sphingolipids; Gangliosides; Lactosylceramide