
Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation
Keywords: ALS2; Rac1; Macropinosome; Endosome; Autophagosome; AmphisomeALS, amyotrophic lateral sclerosis; GEF, guanine nucleotide exchange factor; RLD, regulator of chromosome condensation 1-like domain; DH, Dbl-homology; PH, pleckstrin-homology; VPS9, vacuolar pr