دانلود مقالات ISI درباره PH، همخوانی پلکسترین + ترجمه فارسی

Identification of a novel mouse Dbl proto-oncogene splice variant: Evidence that SEC14 domain is involved in GEF activity regulation

Keywords: PH، همخوانی پلکسترین; Dbl, Diffuse Large B cell Lymphoma; GEF, Guanine nucleotide exchange factor; PH, Pleckstrin homology; DH, Dbl homology; CRAL, Cellular Retinaldehyde domain; TRIO, Triple functional domain; SEC14p, Saccaromyces cerevisiae phosphatidylinositol transfer prot

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Functional characterization of the pleckstrin homology domain of a cellulose synthase from the oomycete Saprolegnia monoica

Keywords: PH، همخوانی پلکسترین; PH, pleckstrin homology; CesA, cellulose synthase; PtdIns, phosphatidylinositide; PtdIns-(3)-P, phosphatidylinositol-(3)-phosphate; PtdIns-(3,4)-P2, phosphatidylinositol-(3,4)-diphosphate; PtdIns-(3,5)-P2, phosphatidylinositol-(3,5)-diphosphate; PtdIns-(4

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer

Keywords: PH، همخوانی پلکسترین; GPCR, G-protein-coupled receptor; PH, pleckstrin homology; PI, phosphatidylinositoll; TGN, trans-Golgi networkPhosphatidylinositol; PI4P; 4-Kinase; Phospholipid

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

α-Syntrophin is required for the hepatocyte growth factor-induced migration of cultured myoblasts

Keywords: PH، همخوانی پلکسترین; PH, pleckstrin homology; SU, syntrophin unique; HGF, hepatocyte growth factor; C57, C57bl6/J; αKO, α-syntrophin knockout; AB, α; β2, syntrophin double knockout; FLA, transgenic mouse expressing full length α-syntrophin only in muscle cells; DMEM, Dulbecco

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Akti-1/2, an allosteric inhibitor of Akt 1 and 2, efficiently inhibits CaMKIα activity and aryl hydrocarbon receptor pathway

Keywords: PH، همخوانی پلکسترین; PI3, phosphatidylinositol 3; CaMK, Ca2+/calmodulin-dependent protein kinase; AhR, aryl hydrocarbon receptor; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; PKB, protein kinases B; PH, pleckstrin homology; Rictor/TORC2, rapamycin-insensitive mTOR complex 2; HE

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

The PH domain adaptor protein Bam32/DAPP1 functions in mast cells to restrain FcɛRI-induced calcium flux and granule release

Keywords: PH، همخوانی پلکسترین; Bam32, B cell adaptor molecule of 32 kDa; BMMC, bone marrow-derived mast cell; DAPP1, dual adaptor for phophotyrosine and phosphoinositides; PH, pleckstrin homology; PI3K, phosphoinositide 3-kinase; SHIP, Src homology 2-containing domain inositol polyphos

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Protein kinase D as a potential new target for cancer therapy

Keywords: PH، همخوانی پلکسترین; PKD, protein kinase D; DAG, diacylglycerol; CaMK, calcium/calmodulin-dependent kinase; PH, pleckstrin homology; PKC, protein kinase C; GPCR, G protein-coupled receptor; ERK, extracellular signal-regulated kinase; HDAC, histone deacetylase; SphK2, sphingos

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

The myriad roles of Anillin during cytokinesis

Keywords: PH، همخوانی پلکسترین; F-actin, filamentous actin; GEF, guanine nucleotide exchange factor; GAP, GTPase activating protein; PH, pleckstrin homology; AH, Anillin homology; SH3, Src homology 3; TCA, trichloroacetic acid; FRET, fluorescence/Förster resonance energy transfer; NLS,

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

PtdIns5P protects Akt from dephosphorylation through PP2A inhibition

Keywords: PH، همخوانی پلکسترین; PtdIns, phosphatidylinositol; PH, Pleckstrin Homology; PX, Phox Homology; FYVE, Fab1p, YOTB, Vps27 and EEA1; PTEN, phosphatase and tensin homologue deleted on chromosome 10; SHIP, SH2 containing inositol lipid phosphatasePtdIns5P; Phosphoinositide; Akt; P

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Differential regulation of Akt/protein kinase B isoforms during cell cycle progression

Keywords: PH، همخوانی پلکسترین; MEF, mouse embryo fibroblast; PI3K, phosphatidylinositol 3-kinase; PtdIns-(3,4,5)P3, phosphatidylinositol 3,4,5-trisphosphate; PTEN, phosphatase and tensin homolog; PKB, protein kinase B; PH, pleckstrin homology; mTOR, mammalian target of rapamycinAkt/pro

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Pasteurella multocida toxin activates Gβγ dimers of heterotrimeric G proteins

Keywords: PH، همخوانی پلکسترین; F, fluorescence; fMLP, formyl-methionyl-leucyl-phenylalanine; GRK, G-protein-coupled-receptor kinase 1; GRP1, general receptor for phosphoinositides-1; IP, inositol phosphates; MEF, mouse embryonic fibroblasts; PH, pleckstrin homology; PI3K, phosphoinosit

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Insulin increase in MAP kinase phosphorylation is shifted to early time-points by overexpressing APS, while Akt phosphorylation is not influenced

Keywords: PH، همخوانی پلکسترین; APS, Adaptor protein with a PH and SH2 domain; CAP, c-Cbl associated protein; CHO-IR, Chinese hamster ovary cells-overexpressing the insulin receptor; IRS, insulin receptor substrate; MAPK, Mitogen activated protein kinase; PH, Pleckstrin Homology; PtdIns

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain

Keywords: PH، همخوانی پلکسترین; Akt, protein kinase B; PI3K, phosphoinositide 3-kinase; PH, pleckstrin homology; PDK1, 3-phosphoinositide-dependent protein kinase 1; DPIEL, deoxyphosphatidylinositol ether lipid; PI, phosphoinositol; kNN, k nearest neighbor; QSAR, quantitative structure–

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Proline Isomerization Preorganizes the Itk SH2 Domain for Binding to the Itk SH3 Domain

Keywords: PH، همخوانی پلکسترین; Itk, interleukin-2 tyrosine kinase; SH3, Src homology 3; SH2, Src homology 2; PH, Pleckstrin homology; pY, phosphotyrosine; RDC, residual dipolar coupling; NOE, nuclear Overhauser enhancement; NOESY, NOE spectroscopy; 3D, three-dimensional; TOCSY, total c

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2009 سفارش ترجمه

Crystal structure of the Bruton’s tyrosine kinase PH domain with phosphatidylinositol

Keywords: PH، همخوانی پلکسترین; SH, Src homology; PH, Pleckstrin homology; PtdIns(3,4,5)P3, phosphatidylinositol-3,4,5-triphosphate; Ins(1,3,4,5)P4, d-myo-inositol 1,3,4,5-tetrakisphosphateComplex structure; Pleckstrin homology domain; Phosphatidylinositol; Membrane targeting; Dimerizat

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Regulation of cell structure and function by actin-binding proteins: Villin’s perspective

Keywords: PH، همخوانی پلکسترین; DSS, dextran sodium sulfate; EMT, epithelial-to-mesenchymal transition; FRET, fluorescence resonance energy transfer; LPA, lysophosphatidic acid; PH, pleckstrin homology; PIP2, phosphatidylinositol 4,5-bisphosphate; PLC-γ1, phospholipase C-gamma 1; SEYFP,

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

The Role of the Conserved Switch II Glutamate in Guanine Nucleotide Exchange Factor-Mediated Nucleotide Exchange of GTP-Binding Proteins

Keywords: PH، همخوانی پلکسترین; GEF, guanine nucleotide exchange factor; GAP, GTPase-activating protein; wt, wild type; DH, dibble homology; PH, pleckstrin homology; GST, glutathione S-transferase; GDI, GDP-dissociation inhibitor; mGDP, 2′,3′-bis(O)-N-methylanthraniloyl-GDPG protein; GE

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1

Keywords: PH، همخوانی پلکسترین; GEF, guanine nucleotide exchange factor; CRD, cysteine-rich domain; DH, Dbl homology; CR, conserved region; EM, electron microscopy; SAXS, small-angle X-ray scattering; GDP, guanosine diphosphate; GTP, guanosine triphosphate; PH, pleckstrin homology; GNE,

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2008 سفارش ترجمه

Human, but not rat, IRS1 targets to the plasma membrane in both human and rat adipocytes

Keywords: PH، همخوانی پلکسترین; GFP, green fluorescent protein; HA, hemagglutinin; IR, insulin receptor; IRS, insulin receptor substrate; PH, pleckstrin homology; PTB, phosphotyrosine binding; SH2, Src homology 2Insulin receptor substrate; Human; Rat; Insulin; Plasma membrane; Signaling

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

High resolution crystal structures of the p120 RasGAP SH3 domain

Keywords: PH، همخوانی پلکسترین; SH3, Src homology 3; SH2, Src homology 2; RasGAP, Ras GTPase activating protein; G3BP, RasGAP SH3 binding protein; p190, Rho GTPase activating protein; PH, pleckstrin homology; SAD, Single-wavelength anomalous diffractionRasGAP; SH3 domain; Dimerization;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver

Keywords: PH، همخوانی پلکسترین; CAR, constitutive active/adrostane receptor; PXR, pregnane X receptor; RXR, retinoid X receptor; ECT2, epithelial cell-transforming gene 2; PH, pleckstrin homology; DH, Dbl homology; TCPOBOP, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene; PB, phenobarbitalNu

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

The lipid-binding SEC14 domain

Keywords: PH، همخوانی پلکسترین; GOLD, Golgi dynamics; PH, pleckstrin homology; PtdCho, phosphatidylcholine; PtdIns, phosphatidylinositol; PtdSer, phosphatidylserine; PX, phox homology; SEC14, Sec14p homology; SPF, supernatant protein factor; TAP, tocopherol-associated proteinSEC14; CRAL

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Structural determinants of LL5β subcellular localisation and association with filamin C

Keywords: PH، همخوانی پلکسترین; PI3K, phosphoinositide 3-OH kinase; PtdIns(3,4,5)P3, phosphatidylinositol 3,4,5-trisphosphate; PKB, protein kinase B; PH, pleckstrin homology; PDGF, platelet derived growth factor.LL5β; filamin; PI3K; PH domain; Cytoskeleton

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

The Grb2/PLD2 Interaction Is Essential for Lipase Activity, Intracellular Localization and Signaling in Response to EGF

Keywords: PH، همخوانی پلکسترین; shRNA, short hairpin RNA; EGFR, epidermal growth factor receptor; PLD, phospholipase D; PH, pleckstrin homology; PX, phox; WT, wild-typePLD2; Grb2; shRNA; co-localization; site-directed mutagenesis

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Role of the α1 integrin cytoplasmic tail in the formation of focal complexes, actin organization, and in the control of cell migration

Keywords: PH، همخوانی پلکسترین; CHO, Chinese hamster ovary; FAK, focal adhesion kinase; GDI, guanine nucleotide dissociation inhibitor; GEF, guanine nucleotide exchange factor; PH, pleckstrin homology; PI3K, phosphatidylinositol 3-kinase; PIP2, phosphatidylinositol-4,5-bisphosphate; PIP

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells

Keywords: PH، همخوانی پلکسترین; PtdIns(3,4)P2, phosphatidylinositol-(3,4)-biphosphate; PtdIns(3,4,5)P3, phosphatidylinositol-(3,4,5)-triphosphate; PtdIns(4,5)P2, phosphatidylinositol-(4,5)-biphosphate; PLC, phospholipase C; PH, pleckstrin homology; PI3-K, phosphoinositide 3-kinase; PTEN

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2007 سفارش ترجمه

Structural Basis for the Phosphorylation-regulated Focal Adhesion Targeting of Type Iγ Phosphatidylinositol Phosphate Kinase (PIPKIγ) by Talin

Keywords: PH، همخوانی پلکسترین; NMR; PTB domain; talin; PIP2, phosphatidylinositol-4,5-bisphosphatePIP2, phosphatidylinositol-4,5-bisphosphate; PIPKIγ, type Iγ phosphatidylinositol phosphate kinase; FA, focal adhesion; PH, pleckstrin homology; ENTH, epsin N-terminal homology; PX, PtdIns

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM

Keywords: PH، همخوانی پلکسترین; ATM, ataxia-telangiectasia mutated; CHX, cycloheximide; CK2, casein kinase-2; CKIP-1, casein kinase-2 interacting protein-1; LZPR, leucine zipper and proline-rich domain; PH, pleckstrin homology; PI3K, phosphoinositol-3-kinaseCKIP-1; ATM; p53 degradation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

AKT can be activated in the nucleus

Keywords: PH، همخوانی پلکسترین; PH, pleckstrin homology; PtdIns, phosphatidylinositol; PI3Ks, phosphoinositide 3-kinases; HEK 293, human embryonic kidney 293; NLS, nuclear localization signal; NES, nuclear export signalAKT; Nuclear localization; Activation; Nucleus

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

γ-Syntrophin scaffolding is spatially and functionally distinct from that of the α/β syntrophins

Keywords: PH، همخوانی پلکسترین; PH, pleckstrin homology; PDZ, domain first identified in PSD-95Discs-large, and ZO-1; RACE, rapid amplification of cDNA ends; Pab, polyclonal antibody; Mab, Monoclonal antibody; GST, glutathione S-transferase; nNOS, neuronal nitric oxide synthase; DGKζ, d

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Coordinated intracellular translocation of phosphoinositide-specific phospholipase C-δ with the cell cycle

Keywords: PH، همخوانی پلکسترین; DG, diacylglycerol; LMB, leptomycin B; NES, nuclear export signal; NLS, nuclear localization signal; NPC, nuclear pore complex; PH, pleckstrin homology; PHD, plant homeodomain; PI, phosphoinositide; PI3K, PtdIns 3-kinase; PKC, protein kinase C; PLC, phosp

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity

Keywords: PH، همخوانی پلکسترین; Cer, ceramide; Sph, sphingosine; CERK, ceramide kinase; SPHK, sphingosine kinase; C1P, ceramide 1-phosphate; S1P, sphingosine 1-phosphate; PH, pleckstrin homology; DGK, diacylglycerol kinase; PIP, phosphatidylinositol phosphateCeramide kinase; Ceramide; C

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه