Dual mechanism of microenvironmental pH modulation and foam melt extrusion to enhance performance of HPMCAS based amorphous solid dispersion
Keywords: API; active pharmaceutical ingredient; ASD; amorphous solid dispersion; HME; Hot-melt extrusion; HPMCAS; Hydroxypropyl methylcellulose acetate succinate; PAT; Process Analytical Technology; QbD; Quality by Design; Foam melt extrusion; Amorphous solid disp