Keywords: متابولیسم فاز I; Bosentan; Perfluorinated analogues; Metabolic specificity; Phase I metabolism; HLM; Cl; Clearance; CYP; Cytochrome P450; DDI; drug-drug interactions; ERA; Endothelin Receptor Antagonist; ET-1; Endothelin 1; ETA; Endothelin receptor A; ETB; Endothelin rece
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Status Epilepticus Decreases Brain Cytochrome P450 2D4 Expression in Rats
Keywords: متابولیسم فاز I; CYP enzymes; phase I metabolism; CNS; drug-metabolizing enzymes; mRNA; HDAC; histone deacetylase; KA; kainic acid; Oct-1; octamer transcription factor 1; SE; status epilepticus; YY1; yin yang 1;
In vitro phase I metabolism of gamabufotalin and arenobufagin: Reveal the effect of substituent group on metabolic stability
Keywords: متابولیسم فاز I; Gamabufotalin; Arenobufagin; CYP enzymes; Phase I metabolism; Human liver microsomes;
Cytochrome P450 Activity in Ex Vivo Cornea Models and a Human Cornea Construct
Keywords: متابولیسم فاز I; cell culture; cell lines; cytochrome P450; phase I metabolism; drug metabolizing enzymes; in vitro models; ophthalmic drug delivery; tissue engineering;
Hepatocytes: The powerhouse of biotransformation
Keywords: متابولیسم فاز I; Hepatocytes; Biotransformation enzymes; Phase I metabolism; Phase II metabolism
Dried chicory root modifies the activity and expression of porcine hepatic CYP3A but not 2C - Effect of in vitro and in vivo exposure
Keywords: متابولیسم فاز I; Detoxification; Bioactive compounds; Phase I metabolism; Boar taint; Gender; Chicory;
Biomimetic in vitro oxidation of lapachol: A model to predict and analyse the in vivo phase I metabolism of bioactive compounds
Keywords: متابولیسم فاز I; Lapachol; Naphtoquinones; Biomimetic oxidation; Jacobsen catalyst; Drug metabolism; Phase I metabolism;
Effects of Uremic Toxins on Transport and Metabolism of Different Biopharmaceutics Drug Disposition Classification System Xenobiotics
Keywords: متابولیسم فاز I; disease effects; BDDCS; organic anion-transporter polypeptide transporters; hepatocytes; CYP enzymes; microsomes; phase I metabolism
An assessment of the impact of physico-chemical and biochemical characteristics on the human kinetic adjustment factor for systemic toxicants
Keywords: متابولیسم فاز I; Human kinetic adjustment factor (HKAF); Interindividual variability; Monte Carlo simulations; Phase I metabolism; Risk assessment; Steady-state conditions; ToxicokineticsADH, alcohol dehydrogenase; CSAF, chemical-specific adjustment factor; CYP, cytochrom
Interstrain Differences of In Vitro Metabolic Stability and Impact on Early Drug Discovery
Keywords: متابولیسم فاز I; ADME; high-performance/pressure liquid chromatography (HPLC); microsomes; mass spectrometry; in vitro models; metabolic clearance; cytochrome P450; phase I metabolism;
Human metabolism of atrazine
Keywords: متابولیسم فاز I; Atrazine; Human liver microsomes; Cytochrome P450; Human liver S9 fractions; Human metabolism; Phase I metabolism; Phase II metabolism; Glutathione conjugation; LC/MS/MS
Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization
Keywords: متابولیسم فاز I; CYP450; Horse; CYP2C; Diclofenac; Mephenytoin; Tolbutamide; Warfarin; Phase I metabolism
Cytochrome P450 expression is moult stage specific and regulated by ecdysteroids and xenobiotics in the crab Carcinus maenas
Keywords: متابولیسم فاز I; Crustacean; CYP; Induction; Moulting; PAH; Phase I metabolism; Gene regulation
Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver
Keywords: متابولیسم فاز I; CYP450; Horse; CYP2D; Dextromethorphan; Debrisoquine; Phase I metabolism
Allosteric kinetics of human carboxylesterase 1: Species differences and interindividual variability
Keywords: متابولیسم فاز I; phase I enzyme; prodrugs; enzyme kinetics; phase I metabolism;
Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells
Keywords: متابولیسم فاز I; HepG2; Hepatocytes; Phase I metabolism; Cytochrome P450; Induction studies; Cytotoxicity
Intermoult duration affects the susceptibility of shore crabs Carcinus maenas (L.) to pyrene and their ability to metabolise it
Keywords: متابولیسم فاز I; P450; CYP; Monooxygenases; Polycyclic aromatic hydrocarbons; Phase I metabolism; Pyrene; 1-Hydroxypyrene; Crustacean
Nuclear Receptors and Drug Disposition Gene Regulation
Keywords: متابولیسم فاز I; induction; phase I metabolism; phase II metabolism; solute transporters; cell biology;