دانلود مقالات ISI درباره فسفودی استراز 4 + ترجمه فارسی

ایمنی درازمدت پماد کراتوورول 2٪ در کودکان و بزرگسالان مبتلا به درماتیت آتوپیک ملایم و متوسط

Long-term safety of crisaborole ointment 2% in children and adults with mild to moderate atopic dermatitis

Keywords: فسفودی استراز 4; atopic dermatitis; crisaborole; eczema; long-term safety; ointment; PDE4; phosphodiesterase-4; topical treatment; AD; atopic dermatitis; AE; adverse event; ISGA; Investigator's Static Global Assessment; PDE4; phosphodiesterase-4; SAE; serious adverse even

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Rates of escalation to triple COPD therapy among incident users of LAMA and LAMA/LABA

Keywords: فسفودی استراز 4; Combination therapy; COPD; Inhaled corticosteroids; Long-acting bronchodilators; LAMA/LABA; Fixed-dose dual bronchodilators; CDS; Chronic Disease Score; CI; confidence interval; COPD; chronic obstructive pulmonary disease; ER; emergency room; FDC; fixed-d

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion

Keywords: فسفودی استراز 4; Bax; Bcl-2 associated x protein; Bcl-2; B-cell lymphoma-2; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; CREB; cAMP-response element binding protein; GFAP; glial fibrillary acidic protein; H&E; haematoxylin and eosin; Iba-1; ionized c

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Design, synthesis, and biological evaluation of novel catecholopyrimidine based PDE4 inhibitor for the treatment of atopic dermatitis

Keywords: فسفودی استراز 4; Atopic dermatitis; Phosphodiesterase-4; Catecholopyrimidine; Dinitrochlorobenzene; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2018 سفارش ترجمه

The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata

Keywords: فسفودی استراز 4; Phosphodiesterase-4; Natural inhibitor; Selaginpulvilins K; Crystal structure; Recognition mechanism;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Reduced COPD Exacerbation Risk Correlates With Improved FEV1

Keywords: فسفودی استراز 4; COPD exacerbations; COPD mechanisms; COPD pharmacology; BD; bronchodilator; dFEV1; between-group difference in change in predose (trough) FEV1 from the beginning to the end of the trial; HR; hazard ratio; non-BD; nonbronchodilator; PDE4; phosphodiesterase

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery and modelling studies of natural ingredients from Gaultheria yunnanensis (FRANCH.) against phosphodiesterase-4

Keywords: فسفودی استراز 4; Phosphodiesterase-4; Gaultheria yunnanensis (FRANCH.); Anti-inflammatory agents

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

OPA-15406, a novel, topical, nonsteroidal, selective phosphodiesterase-4 (PDE4) inhibitor, in the treatment of adult and adolescent patients with mild to moderate atopic dermatitis (AD): A phase-II randomized, double-blind, placebo-controlled study

Keywords: فسفودی استراز 4; atopic dermatitis; atopic eczema; OPA-15406; phosphodiesterase type 4 inhibitor; topical agents; topical calcineurin inhibitor; AD; atopic dermatitis; BSA; body surface area; DLQI; Dermatology Life Quality Index; EASI; Eczema Area and Severity Index; IGA;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

PDE4 Inhibition as Potential Treatment of Epidermolysis Bullosa Acquisita

Keywords: فسفودی استراز 4; Akt; RAC-alpha serine/threonine-protein kinase; COL7; type VII collagen; EBA; epidermolysis bullosa acquisita; IC; immune complex; MAPK; mitogen-activated protein kinase; PD; pemphigoid disease; PDE4; phosphodiesterase-4; PMA; phorbol 12-myristate 13-acet

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2016 سفارش ترجمه

Decrease of phosphorylated CREB and ERK in nucleus accumbens is associated with the incubation of heroin seeking induced by cues after withdrawal

Keywords: فسفودی استراز 4; CREB; cAMP response element binding protein; ERK; extracellular regulated protein kinases; PDE4; phosphodiesterase-4; aCSF; arificial cerebrospinal fluid; Addiction; cAMP; Opioid; Phosphodiesterase-4; Transcription factor;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Roflumilast added to triple therapy in patients with severe COPD: A real life study

Keywords: فسفودی استراز 4; COPD exacerbations; Phosphodiesterase-4 inhibitors; Combination therapy; Side effects; AECOPD; acute exacerbation of COPD; ICS; inhaled corticosteroids; LABA; long-acting β-agonist; LAMA; long-acting muscarinic antagonist; PDE-4; phosphodiesterase-4;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

The molecular basis for the inhibition of phosphodiesterase-4D by three natural resveratrol analogs. Isolation, molecular docking, molecular dynamics simulations, binding free energy, and bioassay

Keywords: فسفودی استراز 4; Phosphodiesterase-4; Resveratrol analog; Inhibition; Mechanism; Modeling; Bioassay;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Methylxanthines do not affect rhythmogenic preBötC inspiratory network activity but impair bursting of preBötC-driven motoneurons

Keywords: فسفودی استراز 4; C4; fourth cervical; CPA; cyclopiazonic acid; DMPX; 3,7-dimethyl-1-propargylxanthine; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; Hepes; hydroxyethyl piperazineethanesulfonic acid; IRCs; ictal respiratory changes; P; postnatal day; PDE4; phosphodiesterase-

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2013 سفارش ترجمه

The type 4 phosphodiesterase inhibitors rolipram and YM976 facilitate recall of the weak version of the passive avoidance task in the day-old chick

Keywords: فسفودی استراز 4; Chick; Phosphodiesterase-4; Rolipram; YM976; Memory; Passive avoidance;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Cilomilast for COPD : Results of a 6-Month, Placebo-Controlled Study of a Potent, Selective Inhibitor of Phosphodiesterase 4

Keywords: فسفودی استراز 4; cilomilast; COPD; phosphodiesterase-4; phosphodiesterase-4 enzymeCI, confidence interval; PDE, phosphodiesterase; SGRQ, St. George’s Respiratory Questionnaire

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Effects of ciclamilast, a new PDE 4 PDE4 inhibitor, on airway hyperresponsiveness, PDE4D expression and airway inflammation in a murine model of asthma

Keywords: فسفودی استراز 4; Phosphodiesterase-4; PDE4D; Ciclamilast; Dexamethasone; Inflammation; Cytokines; Goblet cell; Airways hyperresponsiveness; Asthma

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Treatments for COPD

Keywords: فسفودی استراز 4; ATS; American Thoracic Society; COPD; chronic obstructive pulmonary disease; CXCR1/CXCR2; chemokine receptors 1 and 2; ERS; European Respiratory Society; FEV1; forced expiratory volume in 1 s; GOLD; Global Initiative for Chronic Obstructive Lung Disease;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه

Keynote review: Phosphodiesterase-4 as a therapeutic target

Keywords: فسفودی استراز 4; Pharmaceutical Science; Drug Discovery; Biochemistry; Chemical Biology; Structural Biology; phosphodiesterase-4; rolipram; chronic obstructive pulmonary disease; COPD; asthma; cancer; depression; cyclic AMP;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2005 سفارش ترجمه