Regular articleDevelopment of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro da
Keywords: Brain; Transporter; Lumbar puncture; Blood-brain barrier (BBB); Blood-cerebrospinal fluid barrier (BCSFB); Physiologically-based pharmacokinetic (PBPK) model; In vitro-in vivo extrapolation (IVIVE); Inter-individual variability; Modelling and simulati