Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases
Keywords: IRS, insulin receptor substrate; IGF, insulin-like growth factor; SH2, src homology region 2; Bt2cAMP, dibutyryl cyclic adenosine 3′, 5′-monophosphate; TNF, tumor necrosis factor; PI 3-kinase, phosphoinositide 3-kinase; Grb2, growth factor receptor-bound