دانلود مقالات ISI درباره Pim Kinases + ترجمه فارسی

PIM kinases 1, 2 and 3 in intracellular LIF signaling, proliferation and apoptosis in trophoblastic cells

Keywords: PIM kinases; Trophoblast; Placenta; Intracellular signaling; Reproduction;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

PIM kinases: From survival factors to regulators of cell motility

Keywords: PIM kinases; Cancer; Motility; Migration; Invasion; Metastasis;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis of [11C]CX-6258 as a new PET tracer for imaging of Pim kinases in cancer

Keywords: [11C]CX-6258; Radiosynthesis; Positron emission tomography (PET); Pim kinases; Cancer

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors

Keywords: Pim kinases; Kinase inhibitor; Screening; Fragment based screen; Structure based drug design; Lead optimization;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors

Keywords: PIM kinases; Kinase inhibitors; 1,3,4-Thiadiazol-2-amines; Lead optimization;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2015 سفارش ترجمه

PIM kinase (and Akt) biology and signaling in tumors

Keywords: PIM kinases; Akt; Oncogenes; Cancer; Therapeutic resistance; AML; acute myeloid leukemia; AMPK; AMP activated protein kinase; CXCR-4; C-X-C chemokine receptor type 4; EGFR; epidermal growth factor receptor; EBV; Epstein-Barr virus; FLT3; FMS-like ty

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition

Keywords: Pyrazolo[4,3-a]phenanthridines; Kinase inhibitors; Pim kinases; In vitro antiproliferative activities

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors

Keywords: Pyrazolocarbazoles; Kinase inhibitors; Pim kinases; In vitro antiproliferative activities;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases

Keywords: PIM kinases; Natural product scaffold; Pyrrolopyrazinone; Kinase selectivity; Anti-cancer agents;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design

Keywords: Pim kinases; Kinase inhibitor; Structure based drug design; High throughput screening; Lead optimization

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases

Keywords: PIM kinases; Hit-to-lead; Small molecule inhibitor; Thiazolidine-2,4-dione; X-ray crystallography; Cancer

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Inflammation and survival pathways: Chronic lymphocytic leukemia as a model system

Keywords: CLL; Microenvironment; Bcl-2 family proteins; Pim kinases; Survival pathways

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه