دانلود مقالات ISI درباره PK، فارماکوکینتیک + ترجمه فارسی

یک روش اسپکترومتری جرمی کروماتوگرافی مایع با کارایی بالا برای تعیین آرتمتر و دی هیدروترمیزینین در پلاسمای انسانی

A high-performance liquid chromatography–tandem mass spectrometry method for the determination of artemether and dihydroartemisinin in human plasma

Keywords: PK، فارماکوکینتیک; Artemether; Dihydryartemisinin; Epimerization; Degradation by malaria related hemolytic products; LC–MS/MS; ValidationART, artemether; DHA, dihydroartimisinin; PK, pharmacokinetics; UV, ultraviolet; LLOQ, lower limit of quantitation; APCI, atmospheric pre

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

مدلسازی فارماکوکینتیک مبتنی بر فیزیولوژی برای ارزیابی اثرات متقابل داروهای بالینی با الیزوپروویر

Physiologically based pharmacokinetic modeling for assessing the clinical drug–drug interaction of alisporivir

Keywords: PK، فارماکوکینتیک; CYP, cytochrome P450; DDI, drug–drug interactions; DPM, disintegrations per minute; HCV, hepatitis C virus; HLM, human liver microsomes; PBPK, Physiologically-based pharmacokinetics; PK, pharmacokinetics; TDI, time-dependent inhibitorCL, clearance; Drug–d

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

تبدیل درمان برای بیماران مبتلا به هموفیلی B: به روز رسانی در مورد پیشرفت بالینی فاکتور IX انعقاد نوترکیب اتصال دهنده پروتئین فیوژن نوترکیب با آلبومین نوترکیب (RIX-FP)

Transforming the treatment for hemophilia B patients: update on the clinical development of recombinant fusion protein linking recombinant coagulation factor IX with recombinant albumin (rIX-FP)

Keywords: PK، فارماکوکینتیک; Hemophilia B; PROLONG-9FP; rIX-FP; Recombinant factor IX; On-demand; ProphylaxisAEs, adverse events; AsBR, annualized spontaneous bleeding rate; FIX, factor IX; IV, intravenous; pdFIX, plasma-derived factor IX; PK, pharmacokinetics; rFIX, recombinant fact

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Pharmacokinetics and pharmacodynamics of glycyrrhetinic acid with Paeoniflorin after transdermal administration in dysmenorrhea model mice

Keywords: PK، فارماکوکینتیک; Glycyrrhetinic acid; Paeoniflorin; Pharmacokinetics; Pharmacodynamics; Analgesic; Transdermal drug deliveryPLD, Chinese peony-Liquorice Decoction; GA, glycyrrhetinic acid; PF, paeoniflorin; TTS, transdermal therapeutic system; PK, pharmacokinetics; PD, ph

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Quantification of 5,7-dimethoxyflavone in mouse plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS) and its application to a pharmacokinetic study

Keywords: PK، فارماکوکینتیک; 5,7-DMF, 5,7-dimethoxyflavone; LC–MS/MS, liquid chromatography–tandem mass spectrometry; PK, pharmacokinetics; LLOQ, lower limit of quantification; HPLC, high performance liquid chromatography; GC, gas chromatography; TMF, 5,7,4′-trimethoxyflavone; ACN, a

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Garcinol: Current status of its anti-oxidative, anti-inflammatory and anti-cancer effects

Keywords: PK، فارماکوکینتیک; Garcinia indica; Garcinol; Pharmacodynamics; Pharmacokinetics; ToxicologyG. indica, Garcinia indica; PD, pharmacodynamics; PK, pharmacokinetics; ADME, absorption, distribution, metabolism and elimination; OH•−, hydroxyl radical; ROS, reactive oxygen speci

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Impact of IgG2 high molecular weight species on neonatal Fc receptor binding assays

Keywords: PK، فارماکوکینتیک; HMWs; Aggregates; SEC; Antibody; FcRn bindingmAb, monoclonal antibody; FcRn, neonatal Fc receptor; PK, pharmacokinetics; AlphaScreen, amplified luminescent proximity homogeneous assay screen; SEC, size exclusion chromatography; HMWs, high molecular weight

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Are children undergoing cardiac surgery receiving antibiotics at subtherapeutic levels?

Keywords: PK، فارماکوکینتیک; 16; 20; 27; 41.1%fT, percent of dosing interval; Cmax, maximum total plasma concentration; CPB, cardiopulmonary bypass; IV, intravenous; MIC, minimal inhibitory concentration; PK, pharmacokinetics; VD, volume of distribution

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Metabolism and physiologically based pharmacokinetic modeling of flumioxazin in pregnant animals

Keywords: PK، فارماکوکینتیک; PBPK, physiologically based pharmacokinetics; Km, Michaelis–Menten constant; Vmax, maximum velocity; PPO, protoporphyrinogen oxidase; NMR, nuclear magnetic resonance; MS, mass spectrometry; PK, pharmacokinetics; LSC, liquid scintillation counter; Pt, part

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

The LEVANT I (Lutonix Paclitaxel-Coated Balloon for the Prevention of Femoropopliteal Restenosis) Trial for Femoropopliteal Revascularization : First-in-Human Randomized Trial of Low-Dose Drug-Coated Balloon Versus Uncoated Balloon Angioplasty

Keywords: PK، فارماکوکینتیک; angioplasty; drug-coated balloon; drug-eluting balloon; paclitaxel; peripheral vascular disease; restenosisDCB, drug-coated balloon(s); ITT, intention to treat; LLL, late lumen loss; PK, pharmacokinetics; TLR, target lesion revascularization(s)

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors

Keywords: PK، فارماکوکینتیک; FAAH, fatty acid amide hydrolase; EC, endogenous cannabinoid; AEA, arachidonoylethanolamide; CB1, cannabinoid 1; CB2, cannabinoid 2; SAR, Structure–activity relationship; DMPK, drug metabolism and pharmacokinetics; PK, pharmacokinetics; PD, pharmacodynami

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Lead optimization of isocytosine-derived xanthine oxidase inhibitors

Keywords: PK، فارماکوکینتیک; XOR, xanthine oxidoreductase; XO, xanthine oxidase; PK, pharmacokinetics; AUC, area under curve; XDH, xanthine dehydrogenase; ip, intraperitoneal; po, per oral; SAR, structure–activity relationship; UA, uric acid; sUA, serum UAXanthine oxidase inhibitors;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

A mass balance approach for calculation of recovery and binding enables the use of ultrafiltration as a rapid method for measurement of plasma protein binding for even highly lipophilic compounds

Keywords: PK، فارماکوکینتیک; ADME, absorption, distribution, metabolism, excretion; ED, equilibrium dialysis; EP, eppendorf; NSB, non-specific binding; PD, pharmacodynamics; PK, pharmacokinetics; PPB, plasma protein binding; RED, rapid equilibrium dialysis; UF, ultrafiltrationPlasma

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

The role of hepatic transport and metabolism in the interactions between pravastatin or repaglinide and two rOatp inhibitors in rats

Keywords: PK، فارماکوکینتیک; Oatp, organic anion transporting polypeptide; PK, pharmacokinetics; Oct1, organic cation transporter 1; HBSS, Hank’s balanced salt solution; LC-MS, liquid chromatography tandem mass spectrometry; HP-β cyclodextrin, 2-hydroxypropyl-beta-cyclodextrin; EDTA,

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Pegvisomant bioavailability of single 30 mg/mL subcutaneous injection compared to two 15 mg/mL subcutaneous injections: A pharmacokinetic, safety and tolerability study

Keywords: PK، فارماکوکینتیک; SC, subcutaneous or subcutaneously; IV, intravenous or intravenously; PK, pharmacokinetics; BA, bioavailability; relBA, relative bioavailabilityPegvisomant; Pharmacokinetics; Relative bioavailability; Subcutaneous injection; Acromegaly

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Application of knockout mouse models to investigate the influence of FcγR on the pharmacokinetics and anti-platelet effects of MWReg30, a monoclonal anti-GPIIb antibody

Keywords: PK، فارماکوکینتیک; IgG, immunoglobulin G; FcγR, Fc receptors for IgG; ITP, immune thrombocytopenic purpura; mAbs, monoclonal antibodies; PK, pharmacokinetics; PD, pharmacodynamics; AUC, area under the concentration vs. time profiles; CL, clearance; Vss, volume of distributi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Bisoprolol, ramipril and simvastatin determination in dried blood spot samples using LC–HRMS for assessing medication adherence

Keywords: PK، فارماکوکینتیک; PK, pharmacokinetics; DBS, dried blood spot; LC–HRMS, liquid chromatography–high resolution mass spectrometryDried blood spot (DBS); LC–HRMS; Cardiovascular drugs; Adherence

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

A biomathematical model of the restoring effects of caffeine on cognitive performance during sleep deprivation

Keywords: PK، فارماکوکینتیک; PD, Pharmacodynamic; PK, Pharmacokinetics; PVT, Psychomotor Vigilance Test; RMSE, Root Mean Squared ErrorCaffeine model; Sleep loss; PVT; Individualized modeling; Pharmacokinetic–pharmacodynamic model

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Dynamical models of biomarkers and clinical progression for personalized medicine: The HIV context

Keywords: PK، فارماکوکینتیک; HIV, Human Immunodeficiency Virus; HAART, Highly Active antiretroviral Therapy; TDM, Therapeutic Drug monitoring; STI, Structured Treatment Interruptions; ODE, Ordinary Differential Equation; PK, Pharmacokinetics; PD, Pharmacodynamics; PG, Pharmacogenomic

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Sciatic nerve regeneration is not inhibited by anti-NGF antibody treatment in the adult rat

Keywords: PK، فارماکوکینتیک; ANOVA, analysis of variance; BLQ, below level of quantitation; DRG, dorsal root ganglion; FG, Fluoro-Gold; NGF, nerve growth factor; PK, pharmacokinetics; SFI, Sciatic Functional Indexnerve growth factor; peripheral nerve regeneration; anti-NGF treatment

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

A local effect of CYP24 inhibition on lung tumor xenograft exposure to 1,25-dihydroxyvitamin D3 is revealed using a novel LC–MS/MS assay

Keywords: PK، فارماکوکینتیک; 1,25(OH)2D3, 1,25-dihydroxyvitamin D3; FBS, fetal bovine serum; GUS, β-glucuronidase; LC–MS/MS, liquid chromatography–tandem mass spectrometry; PK, pharmacokinetics; qPCR, quantitative PCRLung cancer; CTA091; CYP24; 1,25-Dihydroxyvitamin D3; Pharmacokinet

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Investigation of dried blood spot card-induced interferences in liquid chromatography/mass spectrometry

Keywords: PK، فارماکوکینتیک; DBS, dried blood spotting; PK, pharmacokinetics; RT, retention time; WB, whole blood; SDS, sodium dodecyl sulfate; IS, internal standard; DMSO, dimethyl sulfoxideLiquid chromatography/mass spectrometry; Dried blood spotting; Interference; Ion-pairing; FTA

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Validation of a gyrolab™ assay for quantification of rituximab in human serum

Keywords: PK، فارماکوکینتیک; PK, pharmacokinetics; ELISA, enzyme-linked immunosorbent assay; CD, compact disk; PBS, phosphate buffered saline; HABA, 4′-hydroxyazobenzene-2-carboxylic acid; QC, quality control; LLOQ, lower limit of quantification; ULOQ, upper limit of quantification;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Quantitative determination of atenolol in dried blood spot samples by LC–HRMS: A potential method for assessing medication adherence

Keywords: PK، فارماکوکینتیک; PK, pharmacokinetics; DBS, dried blood spot; LC–HRMS, liquid chromatography–high resolution mass spectrometryDried blood spot (DBS); Atenolol; Accurate mass; Guthrie card; LC–HRMS; Adherence

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Orally bioavailable allosteric CCR8 antagonists inhibit dendritic cell, T cell and eosinophil migration

Keywords: PK، فارماکوکینتیک; DC, dendritic cell; LPS, lipopolysaccharide; PK, pharmacokinetics; GPCR, G-protein-coupled receptor; hERG, human ether-à-go-go related gene; FEV1, forced expiratory volume 1; KO, knock-out; wt, wild-type; CYP, cytochrome P450; MEC, minimal effective conce

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Lung imaging — Two dimensional gamma scintigraphy, SPECT, CT and PET

Keywords: PK، فارماکوکینتیک; SPECT, single photon emission computed tomography; CT, computed tomography; HRCT, high resolution computed tomography; PET, positron emission tomography; PK, pharmacokinetics; MMAD, mass median aerodynamic diameter; GSD, geometric standard deviation; MDI,

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Pharmacokinetics of IgG1 monoclonal antibodies produced in humanized Pichia pastoris with specific glycoforms: A comparative study with CHO produced materials

Keywords: PK، فارماکوکینتیک; Glycoengineering; Pichia pastoris; Pharmacokinetics; Monoclonal antibody; Mannose; AfucosylationmAb, monoclonal antibody; Fc, antibody fragment crystallizable; FcRn, Neonatal Fc receptor; FcγR, Fc gamma receptor; PK, Pharmacokinetics; PD, Pharmacodynamics

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Evaluation of pharmacokinetic and pharmacodynamic relationship for oral sustained-release atenolol pellets in rats

Keywords: PK، فارماکوکینتیک; AT, atenolol; SRPs, sustained-release pellets; IRPs, immediate-release pellets; PK, pharmacokinetics; PD, pharmacodynamics; HRs, hypertensive rats; SBP, systolic pressureAtenolol; Pharmacokinetics; Pharmacodynamics; Sustained-release pellets; PK–PD relati

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Targeting angiogenesis with compounds from the extracellular matrix

Keywords: PK، فارماکوکینتیک; AAV, adeno-associated virus; ECM, extracellular matrix; FGF, fibroblast growth factor; HSPG, heparan sulfate proteoglycans; MMP, matrix metalloproteinases; NC1, non-collagenous domain 1; PD, pharmacodynamics; PK, pharmacokinetics; TIMP, tissue inhibitor o

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Absorption and tissue distribution of a novel carboxymethyldextran after oral administration

Keywords: PK، فارماکوکینتیک; i.p., Intraperitoneal injection; i.v., Intravenous injection; F, Bioavailability; AUMC, Area under the first moment curve; RGTA, for ReGeneraTing Agent; PK, Pharmacokinetics; Vd, Volume of distribution; AUCCL, Area under curve; CL, Clearance; Cmax, Maximu

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Dexamethasone quantification in dried blood spot samples using LC–MS: The potential for application to neonatal pharmacokinetic studies

Keywords: PK، فارماکوکینتیک; CLD, chronic lung disease; PK, pharmacokinetics; DBS, dried blood spotDried blood spot (DBS); Dexamethasone; Chronic lung disease; Guthrie card; LC–MS

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Drug interactions evaluation: An integrated part of risk assessment of therapeutics

Keywords: PK، فارماکوکینتیک; NDA, new drug application; NME, new molecular entity; ADME, absorption, distribution, metabolism, and/or excretion; PK, pharmacokinetics; PD, pharmacodyanmics; CYP, cytochrome P450; UGT, uridine diphosphate (UDP)-glucuronosyl transferase; P-gp, P-glycopro

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Effects of CYP2D6 status on harmaline metabolism, pharmacokinetics and pharmacodynamics, and a pharmacogenetics-based pharmacokinetic model

Keywords: PK، فارماکوکینتیک; CYP2D6, Cytochrome P450 2D6; PK, pharmacokinetics; PD, pharmacodynamics; EM, extensive metabolizer; PM, poor metabolizer; Tg-CYP2D6, CYP2D6-humanized; IDR, indirect response; HPLC, high performance liquid chromatography; LC-MS/MS, liquid chromatography ta

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Non-linear pharmacodynamics in the transfection efficiency of a non-viral gene delivery system

Keywords: PK، فارماکوکینتیک; pDNA, plasmid DNA; PK, pharmacokinetics; PD, pharmacodynamics; NCL, normal concentration lipoplex; LCL, low concentration lipoplex; CIDIQ, confocal image-assisted three-dimensionally integrated quantification; LFN, LipofectAMINE PLUS; R8-MEND, octaarginin

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Isolation of human anti-idiotypic antibodies by phage display for clinical immune response assays

Keywords: PK، فارماکوکینتیک; pK, pharmacokinetics; IR, immune response; Ab, antibody; mAb, monoclonal antibody; ADA, anti-drug antibody; IgG, immunoglobulin; λ, lambda light chain of an antibody; κ, kappa light chain of an antibody; VH, variable region of the heavy chain of an antibo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Vascular disrupting agents

Keywords: PK، فارماکوکینتیک; VTA, vascular targeting agent; VDA, vascular disrupting agent; TNF-α, tumor necrosis factor α; IFN, interferon; MTD, maximum tolerated dose; PK, pharmacokinetics; PD, pharmacodynamics; TBA, tubulin-binding agent; RhoA, ras homolog gene family (member A);

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه