
Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells
Keywords: PKC، پروتئین کیناز C; DN, diabetic nephropathy; AR, aldose reductase; PKC, protein kinase C; AA, ascorbate; TGF-β, transforming growth factor-β; PARP, poly(ADP-ribose) polymerase; ARI, AR inhibitor; STZ, streptozotocin; NT, nitrotyrosine; AGE, advance glycation end-products; S