Keywords: پلی کیناز 1; DICOM; Digital Imaging and Communications in Medicine; GEMM; genetically engineered mouse model; KP; KRAS TP53; micro-CT; micro-computed tomography; MTC; mass of the thoracic cavity; PLK1; polo-like kinase 1; RECIST; Response Evaluation Criteria in Soli
مقالات ISI پلی کیناز 1 (ترجمه نشده)
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Keywords: پلی کیناز 1; Kinase inhibitor; Polo-like kinase 1; Ras-driven signaling pathways; Non-ATP competitive inhibition; Anti-cancer agents;
Keywords: پلی کیناز 1; Ab; Antibody; ABC; ATP-binding cassette; AIOM; Associazione Italiana di Oncologia Medica; ALCAM; Activated leukocyte cell adhesion molecule; APOD; Apolipoprotein D; AR; androgen receptor; AURKA; Aurora kinase A; AURKB; Aurora kinase B; BCS; Biopharmaceuti
Keywords: پلی کیناز 1; Polo-like kinase 1; Cell cycle; Mitotic arrest; Slippage;
Keywords: پلی کیناز 1; DMA; 2-(dimethylamino)ethyl methacrylate; QDMA; quaternized 2-(dimethylamino)ethyl methacrylate; DEA; 2-(diethylamino)ethyl methacrylate; DPA; 2-(diisopropylamino)ethyl methacrylate; MEMA; N-(morpholino)ethyl methacrylate; FOMA; fluorooctyl methacrylate;
Cyclin-dependent kinase 1-mediated phosphorylation of YES links mitotic arrest and apoptosis during antitubulin chemotherapy
Keywords: پلی کیناز 1; YES; Mitotic phosphorylation; CDK1; Taxol sensitivity; Chemotherapy; CDK1; cyclin-dependent kinase 1; CDKN1A (p21); cyclin-dependent kinase inhibitor 1A; CRISPR; clustered regularly-interspaced short palindromic repeats; KO; knockout; Plk1; Polo-like kina
Hsa-let-7b inhibits cell proliferation by targeting PLK1 in HCC
Keywords: پلی کیناز 1; Polo-like kinase 1; Survivin; Let-7b; Proliferation; Apoptosis;
Potential role for microRNA in regulating hypoxia-induced metabolic suppression in jumbo squids
Keywords: پلی کیناز 1; OMZ; oxygen minimum zone; PO2; partial pressure of oxygen; Pcrit; passive pharyngeal critical closing pressure; miRNA; microRNA; miRISC; miRNA-induced RNA silencing complex; ROS; reactive oxygen species; NOX4; NADPH oxidase 4; ERK/MAPK; extracellular sign
Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups
Keywords: پلی کیناز 1; BRD4; BI2536; Indoline; WPF binders; c-Myc; PD-L1; BCPs; Bromodomain-containing proteins; BET; bromodomain and extra-terminal; BRD4-BD1; first bromodomain of BRD4; CREB; cyclic-AMP response element binding protein; FA; fluorescence anisotropy; FBDD; fragm
Theoretical studies on benzimidazole and imidazo[1,2-a]pyridine derivatives as Polo-like kinase 1 (Plk1) inhibitors: Pharmacophore modeling, atom-based 3D-QSAR and molecular docking approach
Keywords: پلی کیناز 1; Polo-like kinase 1; Pharmacophore modeling; 3D-QSAR; Docking; Benzimidazole; Imidazo[12-a]pyridines;
Original ArticleMutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors
Keywords: پلی کیناز 1; Polo-like kinase 1; Head neck squamous cell carcinoma; WEE1; CHK1; AJUBA; AUC; area under the curve; BrdU; bromodeoxyuridine; CCC; concordance correlation coefficient; CHK1/2; checkpoint kinases 1 and 2; FDR; false-discovery rate; HNSCC; head and neck squ
Recruitment of PP1 to the centrosomal scaffold protein CEP192
Keywords: پلی کیناز 1; CEP192; Protein phosphatase one; Polo-like kinase one; Mitosis; Centrosome; PLK1; Polo-like kinase 1; Nek2A; NIMA-related kinase 2A; CEP192; centrosomal protein of 192Â kDa; PCM; pericentriolar matrix; PP1; protein phosphatase 1;
Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor
Keywords: پلی کیناز 1; BRD4 inhibitor; Kinase; BI-2536; Dihydroquinoxalin-2(1H)-one; PLK1; Polo-like Kinase 1; JAK2; Janus kinase 2; PTMs; post-translational modifications; KAc; acetylated lysine; BET; Bromodomain and Extra-Terminal; P-TEFb; positive transcription elongation fa
Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities
Keywords: پلی کیناز 1; Nek2 inhibitors; Imidazo[1,2-a]pyridine; Antitumor activity; Selectivity; Nek2; NIMA-related kinase 2; Nlp; ninein-like protein; SAC; spindle assembly checkpoint; Mad1/2; mitotic arrest deficient 1/2; Hec1; highly expressed in cancer 1; CIN; chromosome in
Original articleDecreased PLK1 expression denotes therapy resistance and unfavourable disease-free survival in rectal cancer patients receiving neoadjuvant chemoradiotherapy
Keywords: پلی کیناز 1; CRT; chemoradiotherapy; DSB; double-strand break; FFPE; formalin-fixed paraffin-embedded; MRI; magnetic resonance imaging; MTA; microtubule-targeting agent; Plk1; Polo-like kinase 1; TMA; tissue microarray; Chemoradiotherapy; Polo-like kinase 1; Predictiv
Compression regulates gene expression of chondrocytes through HDAC4 nuclear relocation via PP2A-dependent HDAC4 dephosphorylation
Keywords: پلی کیناز 1; HDAC4; histone deacetylase 4; GFP; green fluorescent protein; PI; propidium iodide; PP2A; Ser/Thr-phosphoprotein phosphatases 2A; OA; okadaic acid; Ps-HDAC4; phosphorylated-HDAC4; LK1; polo-like kinase 1; CDKN1A; cyclin-dependent kinase inhibitor 1A; Mech
MST2 phosphorylation at serine 385 in mitosis inhibits its tumor suppressing activity
Keywords: پلی کیناز 1; CDK1; cyclin-dependent kinase 1; LATS1/2; large tumor suppressor 1/2; MST1/2; mammalian sterile 20-like kinase 1/2; PLK1; polo-like kinase 1; TAZ; transcriptional co-activator with PDZ binding domain; YAP; yes-associated protein; MST2; Mitotic phosphoryla
Identification of acylthiourea derivatives as potent Plk1 PBD inhibitors
Keywords: پلی کیناز 1; Polo-like kinase 1; Polo-box domain; Small molecular inhibitor; Halogenosulfamoylphenyl acylthiourea; Binding affinity; In vitro assay;
Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors
Keywords: پلی کیناز 1; Polo-like kinase 1; Non-ATP-competitive; Inhibitors; Structure–activity relationship
Therapeutic polo-like kinase 1 inhibition results in mitotic arrest and subsequent cell death of blasts in the bone marrow of AML patients and has similar effects in non-neoplastic cell lines
Keywords: پلی کیناز 1; PLK1; Polo-like kinase 1; AML; acute myeloid leukemia; BMB; bone marrow biopsies; AML-MRC; AML with myelodysplasia related changes; CAE; chloroacetate esterase; HPF; high power field; HSCT; hematopoietic stem cell transplantation; AML; PLK1 inhibition; BI
The Catalytic Subunit of DNA-Dependent Protein Kinase Coordinates with Polo-Like Kinase 1 to Facilitate Mitotic Entry
Keywords: پلی کیناز 1; DNA-PKcs; DNA-dependent protein kinase catalytic subunit; Plk1; polo-like kinase 1; PBD; polo box domain;
Vanillin-derived antiproliferative compounds influence Plk1 activity
Keywords: پلی کیناز 1; Antiproliferative compounds; Polo-like kinase 1; Cell cycle;
Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases
Keywords: پلی کیناز 1; PARP; poly ADP ribose polymerase; PLK1; polo-like kinase 1; PP1; protein phosphatase 1; PP2A; protein phosphatase 2A; PP6; protein phosphatase 6; Aurora A; CDK1; IK; Mitotic arrest; Protein phosphatase;
Plk1-targeted therapies in TP53- or RAS-mutated cancer
Keywords: پلی کیناز 1; Polo-like kinase 1; p53; KRAS; Prognosis; Tissue distribution; Structure
Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4
Keywords: پلی کیناز 1; ECT2; the epithelial cell transforming protein 2; DH-PH; Dbl homology domain and Pleckstrin homology domain; Plk1; Polo-like kinase 1; MKLP1; mitotic kinesin-like protein 1; ITC; isothermal titration calorimetry; TEV; tobacco etch virus; IPTG; isopropyl
Matrix metalloproteinase 2-responsive micelle for siRNA delivery
Keywords: پلی کیناز 1; siRNA delivery; Micelleplex; Cancer therapy; Matrix metalloproteinase-2 responsiveness; Polo-like kinase 1;
Aromatic diacylhydrazine derivatives as a new class of polo-like kinase 1 (PLK1) inhibitors
Keywords: پلی کیناز 1; Polo-like kinase 1; Aromatic diacylhydrazine; Computer simulation;
Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights
Keywords: پلی کیناز 1; HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki
Human ABCB1 (P-glycoprotein) and ABCG2 mediate resistance to BI 2536, a potent and selective inhibitor of Polo-like kinase 1
Keywords: پلی کیناز 1; MDR; multidrug resistance; ABC; ATP-binding cassette; Plk-1; Polo-like kinase 1; PhA; pheophorbide A; FTC; Fumitremorgin C; MTT; 3-(4,5-dimethylthiazol-yl)-2,5-diphenyllapatinibrazolium bromide; Vi; sodium orthovanadate; ABC transporter; Multidrug resista
High expression of polo-like kinase 1 is associated with the metastasis and recurrence in urothelial carcinoma of bladder
Keywords: پلی کیناز 1; Polo-like kinase 1; Bladder urothelial carcinoma; Histopathologic grade; Clinical stage; Scytonemin
Clinicopathological significance of Polo-like kinase 1 (PLK1) expression in human malignant glioma
Keywords: پلی کیناز 1; PLK1, Polo-like kinase 1; WHO, World Health Organization; KPS, Karnofsky Performance Scale; RNAi, RNA interference; RT-PCR, reverse transcriptase polymerase chain reaction; AAan, aplastic astrocytoma; GBM, Glioblastoma multiformeGlioma; Polo-like kinase 1
A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo
Keywords: پلی کیناز 1; cDNA; Complementary DNA; CHE; Cholesteryl hexadecyl ether; Chol; Cholesterol; DMEM; Dulbecco's modified Eagle medium; DMG; Dimyristoyl-sn-glycerol; DSG; Distearoyl-sn-glycerol; DODAP; 1,2-Dioleoyl-3-dimethylammonium propane; DOPC; 1,2-Dioleoyl-sn-glycero-
QSAR, molecular docking studies of thiophene and imidazopyridine derivatives as polo-like kinase 1 inhibitors
Keywords: پلی کیناز 1; Polo-like kinase 1; Quantitative structure activity relationship; CoMFA; CoMSIA; Molecular docking
In vivo tumor imaging using polo-box domain of polo-like kinase 1 targeted peptide
Keywords: پلی کیناز 1; Polo-like kinase 1; Polo-box domain; cRGDyK-S-S-CPLHSpT; Drug delivery; Molecular imaging; PET;
Overexpression of polo-like kinase 1 and its clinical significance in human non-small cell lung cancer
Keywords: پلی کیناز 1; PLK1; Polo-like kinase 1; NSCLC; non-small cell lung cancer; RNAi; RNA interference; RT-PCR; reverse transcript-polymerase chain reaction; Polo-like kinase 1; Non-small cell lung cancer; Immunohistochemistry; Prognosis; RNA interference; Apoptosis; Chemot
Reciprocal Activation Between PLK1 and Stat3 Contributes to Survival and Proliferation of Esophageal Cancer Cells
Keywords: پلی کیناز 1; Neoplasm; Signaling; Transcriptional Regulation; Cell Death; ChIP; chromatin immunoprecipitation; DN; dominant negative; EGFP; enhanced green fluorescent protein; EMSA; electrophoretic mobility shift assay; ESCC; esophageal squamous cell carcinoma; FITC;
Reduced Efficacy of the Plk1 Inhibitor BI 2536 on the Progression of Hepatocellular Carcinoma due to Low Intratumoral Drug Levels
Keywords: پلی کیناز 1; AdV; adenovirus; CMV; cytomegalia virus; FACS; fluorescence-activated cell sorting; GEM; genetically engineered mouse; HCC; hepatocellular carcinoma; MRI; magnetic resonance imaging; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PARP;
Phosphopeptides with improved cellular uptake properties as ligands for the polo-box domain of polo-like kinase 1
Keywords: پلی کیناز 1; Phosphopeptides; Cell-penetrating peptides; Polo-like kinase 1; Polo-box domain; Cellular uptake
Illumination of mitotic orchestra during cell division: A polo view
Keywords: پلی کیناز 1; Polo-like kinase 1; Protein kinase and phosphatase signaling cascade; Ubiquitination; Crosstalk; Mitosis
Polo-like kinase 1 contributes to the tumorigenicity of BEL-7402 hepatoma cells via regulation of Survivin expression
Keywords: پلی کیناز 1; Polo-like kinase 1; Survivin; BEL-7402 cells; Xenograft model; Caspase-3
Expression, adverse prognostic significance and therapeutic small molecule inhibition of Polo-like kinase 1 in multiple myeloma
Keywords: پلی کیناز 1; Polo-like kinase 1; PLK1; Multiple myeloma; Novel therapeutics
Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy
Keywords: پلی کیناز 1; siRNA delivery; Nanoparticle; RNA interference; Cancer therapy; Polo-like kinase 1
Actin cytoskeleton dynamics and the cell division cycle
Keywords: پلی کیناز 1; APC; adenomatous polyposis coli; CDK1; cyclin-dependent kinase 1; ECM; extra cellular matrix; FAK; focal adhesion kinase; GAP; GTPase-activating protein; GEF; guanine nucleotide exchange factor; MLCK; myosin light chain kinase; PAK; p21-activate kinase; P
Cytokinesis and cancer: Polo loves ROCK‘n’ Rho(A)
Keywords: پلی کیناز 1; Polo-like kinase 1; RhoA GTPase; Rho kinase; cytokinesisPlk1, Polo-like kinase 1; GEF, guanine nucleotide-exchange factor; GAP, GTPase-activating protein; ROCK, Rho-associated coiled- coil-forming kinase; MLC, myosin light chain
Many roads lead to primary autosomal recessive microcephaly
Keywords: پلی کیناز 1; 53BP1; tumor-suppressor protein p53 binding protein 1; APC; anaphase-promoting complex; ASPM; abnormal spindle-like, microcephaly associated protein; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and RAD3-related protein; BACH1; BRCA1-ass
Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells
Keywords: پلی کیناز 1; Apoptosis; Kaempferol; Polo-like kinase 1; Caspase; Poly-ADP-ribose polymerase
The polo-like kinase 1 regulates CDC25B-dependent mitosis entry
Keywords: پلی کیناز 1; CDC25B phosphatase; Polo-like kinase 1; Mitosis; G2/M checkpoint
Identification of a nuclear localization signal in the polo box domain of Plk1
Keywords: پلی کیناز 1; Polo-like kinase 1; Polo box domain; Nuclear localization signal; Transportin; Importin α
Regression of pressure-induced left ventricular hypertrophy is characterized by a distinct gene expression profile
Keywords: پلی کیناز 1; DAVID; Database for Annotation, Visualization, and Integrated Discovery; Hpcal1; hippocalin-like 1; Limma; linear models for microarray; LV; left ventricular; LVH; left ventricular hypertrophy; PCR; polymerase chain reaction; Plk1; polo-like kinase 1; SAF
Effect of trastuzumab-modified antisense oligonucleotide-loaded human serum albumin nanoparticles prepared by heat denaturation
Keywords: پلی کیناز 1; Albumin; Nanoparticle; Antisense; Drug delivery; Polo-like kinase 1; Heat stabilisation