p53 as a target for the treatment of cancer
Keywords: p53; Cancer; Therapeutic target; PRIMA-1; PRIMA-1MET; Nutlin; Triple negative breast cancer;
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PRIMA-1 induces autophagy in cancer cells carrying mutant or wild type p53
Keywords: PRIMA-1; Autophagy; p53; LC3; Electron microscopy;
Hypoxia, Mn-SOD and H2O2 regulate p53 reactivation and PRIMA-1 toxicity irrespective of p53 status in human breast cancer cells
Keywords: DN-mutant p53 R175H; dominant-negative mutant p53 Arg 175His; wt; wild type; PARP; poly(ADP-ribose) polymerase; [Mn-SOD, SOD2]; manganese-dependent superoxide dismutase; [Cu/Zn-SOD, SOD1]; copper-zinc-dependent superoxide dismutase; BSO; buthionine sulf
The p53 tumor suppressor: A master regulator of diverse cellular processes and therapeutic target in cancer
Keywords: p53; Tumor suppressor; Apoptosis; Wrap53; Antisense RNA; PRIMA-1; APR-246; Cancer therapy
PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells
Keywords: PRIMA-1; Mutant p53; Nucleolus; p53 degradation; p53 ubiquitylation; Breast cancer;
The aflatoxin-induced TP53 mutation at codon 249 (R249S): Biomarker of exposure, early detection and target for therapy
Keywords: Aflatoxin; Hepatitis B virus; Codon 249; p.R249S; Biomarker; PRIMA-1
PRIMA-1 induces apoptosis by inhibiting JNK signaling but promoting the activation of Bax
Keywords: PRIMA-1; p53; Apoptosis; Breast cancer; Chromatin immunoprecipitation; ChIP; Bax; PUMA; c-Jun N-terminal kinasePRIMA-1, p53 reactivation and induction of massive apoptosis; p53BS, p53 binding site; ADR, adriamycin; ChIP, chromatin immunoprecipitation; JNK
Expression proteomics to p53 mutation reactivation with PRIMA-1 in breast cancer cells
Keywords: Proteomics; PRIMA-1; Apoptosis; Breast cancer; Mass spectrometry; 2-D gel electrophoresis; VDAC2
p53-dependent inhibition of progestin-induced VEGF expression in human breast cancer cells
Keywords: P; progesterone; PR; progesterone receptor; E; estrogen; ER; estrogen receptor; HRT; hormone replacement therapy; MPA; medroxy progesterone acetate; VEGF; vascular endothelial growth factor; PRIMA-1; p53 reactivation induction of massive apoptosis; RT; re