Keywords: خشک کردن اولیه; Freeze-drying; Lyophilization; Process analytical technology; Impedance spectroscopy; Dual electrode; Primary drying; Ice interface temperature; Heat transfer coefficient; Dielectric relaxation of ice;
مقالات ISI خشک کردن اولیه (ترجمه نشده)
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Keywords: خشک کردن اولیه; Lyophilization; Freeze-drying; Ramp rate; Primary drying; Collapse; Aggressive cycle;
An Integrated Process Analytical Technology (PAT) Approach to Monitoring the Effect of Supercooling on Lyophilization Product and Process Parameters of Model Monoclonal Antibody Formulations
Keywords: خشک کردن اولیه; lyophilization; process analytical technology (PAT); primary drying; secondary drying; ice nucleation; monoclonal antibody; formulation; freeze drying; product temperature; dry layer thickness;
Lyophilization Process Design Space
Keywords: خشک کردن اولیه; freeze-drying/lyophilization; quality by design (QbD); process analytical technology (PAT); Design Space; processing; Scale-Up; heat and mass transfer; process validation; primary drying;
Determination of the Influence of Primary Drying Rates on the Microscale Structural Attributes and Physicochemical Properties of Protein Containing Lyophilized Products
Keywords: خشک کردن اولیه; lyophilization; primary drying; micro-X-ray computed tomography; bovine serum albumin; microcollapse;
In-line monitoring of the primary drying phase of the freeze-drying process in vial by means of a Kalman filter based observer
Keywords: خشک کردن اولیه; DPE, dynamic parameters estimation; EKF, extended Kalman filter; MTM, manometric temperature measurement; PRT, pressure rise test; SDP, semi-definite positiveFreeze-drying; Lyophilisation; Primary drying; Modelling; Monitoring; Extended Kalman filter
A procedure to optimize scale-up for the primary drying phase of lyophilization
Keywords: خشک کردن اولیه; freeze-drying; primary drying; computational modeling; heat and mass transfer; process development;
Development of simplified models for the freeze-drying process and investigation of the optimal operating conditions
Keywords: خشک کردن اولیه; Freeze-drying; Primary drying; Modelling; Simplified models;
Rapid determination of dry layer mass transfer resistance for various pharmaceutical formulations during primary drying using product temperature profiles
Keywords: خشک کردن اولیه; Collapse temperature; Dry layer product resistance parameters; FORTRAN; Lactose dehydrogenase (LDH); 5% Mannitol; Mass transfer resistance; Micro-collapse; Newton–Ralphson iteration; Powell's optimization algorithm; Primary drying; Primary drying subrouti