Amyloid-β(1-42) protofibrils stimulate a quantum of secreted IL-1β despite significant intracellular IL-1β accumulation in microglia
Keywords: پروتوفیبریل; AD, Alzheimer’s disease; Aβ, amyloid-β protein; aCSF, artificial cerebrospinal fluid; HFIP, hexafluoroisopropanol; IL-1β, interleukin-1β; SEC, size exclusion chromatography; ThT, thioflavin T; TNFα, tumor necrosis factor αAmyloid-beta protein; Protofibril