دانلود مقالات ISI درباره PS، presenilin + ترجمه فارسی

Behavioral and EEG changes in male 5xFAD mice

Keywords: PS، presenilin; Aβ, amyloid-β; AD, Alzheimer's disease; APP, amyloid precursor protein; EEG, electroencephalogramm; EMG, electromyogram; FAD, familiar Alzheimer's disease; PS, presenilin; REM, rapid eye movement sleep; SWS, slow-wave sleep; TS, total sleep; W, waking5xFA

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Brain excitability and connectivity of neuronal assemblies in Alzheimer's disease: From animal models to human findings

Keywords: PS، presenilin; AD, Alzheimer's disease; MCI, Mild Cognitive Impairment; aMCI, amnestic Mild Cognitive Impairment; CSF, cerebrospinal fluid; MRI, Magnetic Resonance Imaging; Aβ, amyloid-β; APP, Amyloid Precursor Protein; NFTs, NeuroFibrillary Tangles; PS, presenilin; CFC

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Presenilin 1-related alterations in DNA integrity in a transgenic mouse model of Alzheimer's disease

Keywords: PS، presenilin; APP, amyloid precursor protein; ISNT, in situ nick translation; PS, presenilin; SIPB, synaptophysin-immunoreactive presynaptic boutons; SL, stratum lucidum of hippocampal area CA3; SM, stratum moleculare of the dentate gyrus; SR, stratum radiatum of hippo

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Epigenetic regulation in the pathophysiology of Alzheimer's disease

Keywords: PS، presenilin; AD, Alzheimer's disease; APP, amyloid-precursor protein; PS, presenilin; fAD, familial AD; Apo, Apolipoprotein; sAD, sporadic AD; Aβ, beta-amyloid; SAM, s-adenosylmethionine; C, cytosine; G, guanine; DNMT, DNA methyltransferase; SAH, s-adenylohomocysteine

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

TRAF6 promotes ubiquitination and regulated intramembrane proteolysis of IL-1R1

Keywords: PS، presenilin; PMA, phorbol 12-myristate-13-acetate; TNF, tumor necrosis factor; TRAF6, tumor necrosis factor receptor-associated factor-6; CTD, C-terminal fragment; ICD, intracellular domain; IL, interleukin; PS, presenilin; RIP, regulated intramembrane proteolysisInte

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

An alternative spliced mouse presenilin-2 mRNA encodes a novel γ-secretase inhibitor

Keywords: PS، presenilin; PS, presenilin; PEN-2, presenilin enhancer 2; APH-1, anterior pharynx-defective phenotype 1; NCT, nicastrin; CHAPS, 3-cholamidopropyl dimethylammonio propanesulfonic acid; mRFP, monomeric red fluorescence proteinPresenilin; Alternative splicing; γ-Secreta

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1

Keywords: PS، presenilin; BACE1, β-site APP cleaving enzyme; APP, amyloid precursor protein; Aβ, β amyloid; PS, presenilin; ERK1/2, extracellular signal regulated MAP kinase; Akt, serine/threonine kinase Akt/protein kinase B; SEK, stress-activated protein kinase-ERK kinase; PAK, p

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution

Keywords: PS، presenilin; APP, β-amyloid precursor protein; PS, presenilin; NCT, nicastrin; S2P, site 2 protease; Aβ, amyloid β; EM, electron microscopy; STEM, scanning transmission electron microscopy; BN, Blue Native; MW, molecular weight; Con A, concanavalin A; MBP, maltose-bin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

In vitro reconstitution of γ-secretase activity using yeast microsomes

Keywords: PS، presenilin; Aβ, amyloid β peptides; APP, amyloid precursor protein; AICD, APP intracellular domain; Aph-1, anterior pharynx-1; CTF, carboxyl-terminal fragment; PS, presenilin; NCT, nicastrin; Pen-2, presenilin enhancer-2; wt, wildtype; PC, phosphatidyl choline; CHAPS

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Both the N-terminal fragment and the protein–protein interaction domain (PDZ domain) are required for the pro-apoptotic activity of presenilin-associated protein PSAP

Keywords: PS، presenilin; AD, Alzheimer's disease; PS, presenilin; PSAP, presenilin-associated protein; siRNA, small interfering RNA; FISH, fluorescence in situ hybridization; SMART, Simple Modular Architecture Research ToolApoptosis; Mitochondria; Caspase; Cytochrome c; Cell deat

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

The Alzheimer's disease-associated γ-secretase complex: Functional domains in the presenilin 1 protein

Keywords: PS، presenilin; AD, Alzheimer's disease; APP, amyloid β-precursor protein; Aβ, Amyloid β-peptide; PS, presenilin; TM, transmembrane; AICD, APP intracellular domain; NTF, N-terminal fragment; CTF, C-terminal fragment; RIP, regulated intramembrane proteolysis; I-CliP, intr

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels

Keywords: PS، presenilin; AD, Alzheimer's disease; FAD, familial form of Alzheimer's disease; Aβ, amyloid β-peptide; APP, amyloid precursor protein; PS, presenilin; ER, endoplasmic reticulum; IP3, inositol 1,4,5-trisphosphate; Bk, bradykinin; Hist, histamine; Cch, carbachol; Tg, t

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Blocking the cleavage at midportion between γ- and ε-sites remarkably suppresses the generation of amyloid β-protein

Keywords: PS، presenilin; Aβ, amyloid β-protein; AD, Alzheimer’s disease; APP, β-amyloid precursor protein; AICD, APP intracellular domain; βCTF, β-carboxyl-terminal fragment; CHO, Chinese hamster ovary; mt, mutant; PS, presenilin; TMD, transmembrane domain; TOF MS, time-of-flight

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه