دانلود مقالات ISI درباره PXR، گیرنده حامل X + ترجمه فارسی

نقش گیرنده باردار حامله انسان در چاقی ناشی از رژیم غذایی با چربی در موش های ماده قبل از یائسگی

Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice

Keywords: PXR، گیرنده حامل X; HFD, high-fat diet; PXR, pregnane X receptor; mPXR, mouse PXR; hPXR, PXR-humanized or human PXR; WT, wild type; WAT, white adipose tissue; BAT, brown adipose tissue; ALT, alanine transaminase; PPARs, peroxisome proliferator-activated receptors; LBD, ligan

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells

Keywords: PXR، گیرنده حامل X; Pregnane X receptor; SUMOylation; Transcriptional activity; CYP3A4; P-gpSUMO, small ubiquitin-related modifier; PXR, pregnane X receptor; RIF, rifampicin; CYP3A4, cytochrome P450 3A4; P-gp, p-glycoprotein; MDZ, midazolam; 1′-OHMDZ, 1′-Hydroxymidazolam; Rh

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

MicroRNA-30c-1-3p is a silencer of the pregnane X receptor by targeting the 3′-untranslated region and alters the expression of its target gene cytochrome P450 3A4

Keywords: PXR، گیرنده حامل X; CYP3A4, cytochrome P450 3A4; DMEM, Dulbecco's modified eagle medium; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; miR, microRNA; PXR, pregnane X receptor; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; UTR, untranslated regionN

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Mixed-ligand copper(II) complexes activate aryl hydrocarbon receptor AhR and induce CYP1A genes expression in human hepatocytes and human cell lines

Keywords: PXR، گیرنده حامل X; AhR, aryl hydrocarbon receptor; AR, androgen receptor; CYP, cytochrome P450; DEX, dexamethasone; DHT, dihydrotestosterone; DMF, N,N dimethylformamide; GR, glucocorticoid receptor; PXR, pregnane X receptor; RIF, rifampicin; RVT, resveratrol; T3, 3,3′,5-tri

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

A SUMO-acetyl switch in PXR biology

Keywords: PXR، گیرنده حامل X; PXR, pregnane X receptor; TSA, trichostatin A; HDAC3, histone de-acetylase 3; SMRT, silencing mediator of retinoic acid and thyroid hormone receptor; PTM, post-translational modification; LC–MS/MS, liquid chromatography–tandem mass spectrometry; PIAS1, pr

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor

Keywords: PXR، گیرنده حامل X; Constitutive androstane receptor; CINPA1; Inverse agonist; TR-FRETCAR, constitutive androstane receptor; PXR, pregnane X receptor; NR, nuclear receptor; CYP2Bs, cytochrome P450, family 2, subfamily B proteins; CYP2Cs, cytochrome P450, family 2, subfamily

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2016 سفارش ترجمه

Disruption of HNF1α binding site causes inherited severe unconjugated hyperbilirubinemia

Keywords: PXR، گیرنده حامل X; CAR, Constitutive androstane receptor; CNS, Crigler-Najjar syndrome; gtPBREM, phenobarbital-responsive enhancer module; HNF1α, Hepatic nuclear factor 1α; NT, nucleotide; PXR, Pregnane X Receptor; UCB, unconjugated bilirubin; UGT1A1, Uridine Diphosphate Gl

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function

Keywords: PXR، گیرنده حامل X; PXR, pregnane X receptor; PGC-1α, peroxisome proliferator-activated receptor γ coactivator 1 alpha; SIRT1, sirtuin 1; CYP, cytochrome P450; PCN, pregnenolone-16α-carbonitrile; PPARα, peroxisome proliferator-activated receptor alpha; DMSO, dimethyl sulfoxi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells

Keywords: PXR، گیرنده حامل X; CYP, cytochrome P450; miRNA, microRNA; DMETs, drug metabolizing enzymes and transporters; PM, poor metabolizer; EM, extensive metabolizer; ERα, estrogen receptor α; CAR, constitutive androstane receptor; PXR, pregnane X receptor; RE, response element; 3′-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR

Keywords: PXR، گیرنده حامل X; DIM, , 3,3′-diindolylmethane; PXR, pregnane X receptor; hPXR, human pregnane X receptor; mPXR, mouse pregnane X receptor; rPXR, rat pregnane X receptor; CYP, cytochrome p450; CYP3A4, cytochrome p450 3A4; MDR1, multidrug resistance protein 1; DMSO, dimethy

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines

Keywords: PXR، گیرنده حامل X; AhR, aryl hydrocarbon receptor; DEX, dexamethasone; GR, glucocorticoid receptor; PXR, pregnane X receptor; RIF, rifampicin; RU486, mifepristone; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxinXenoreceptors; Gene reporter assay; Enantiospecificity; Chiral drugs;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Effect of repeated dosing on rifampin exposure in BALB/c mice

Keywords: PXR، گیرنده حامل X; CYP3A, cytochrome P450 3A; Pgp, P-glycoprotein; PXR, pregnane X receptor; TB, tuberculosisMouse; Rifampin; CYP3A; Pgp; Induction

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

PXR-mediated P-glycoprotein induction by small molecule tyrosine kinase inhibitors

Keywords: PXR، گیرنده حامل X; ABC, ATP-binding cassette; ATP, adenosine triphosphate; DMSO, dimethylsulfoxide; MDCKII, Madin Darby canine kidney II – MDCKII; MDR1, multidrug resistance protein 1; NR, nuclear receptor; PGP, P-glycoprotein; PXR, pregnane X receptor; siRNA, short inhibit

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Effects of artificial sweeteners on the AhR- and GR-dependent CYP1A1 expression in primary human hepatocytes and human cancer cells

Keywords: PXR، گیرنده حامل X; AhR, Aryl hydrocarbon Receptor; CAR, Constitutive androstane receptor; ER, estrogen receptor; GR, glucocorticoid receptor; LXR, liver X receptor; PXR, pregnane X receptor; RXR, retinoic X receptor; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxinArtificial sweet

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Role of the nuclear xenobiotic receptors CAR and PXR in induction of cytochromes P450 by non-dioxinlike polychlorinated biphenyls in cultured rat hepatocytes

Keywords: PXR، گیرنده حامل X; PCBs, polychlorinated biphenyls; DL, dioxinlike; NDL, non-dioxinlike; CAR, constitutive androstane receptor; PXR, pregnane X receptor; CYP, cytochrome P450; siRNA, small interfering RNA; OA, okadaic acid; PB, phenobarbital; Dex, dexamethasonePolychlorinat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1

Keywords: PXR، گیرنده حامل X; CYP, cytochrome P450; KET, ketoconazole; MDR1, multidrug resistance protein 1; PCN, pregnenolone-16α-carbonitrile; PIP, piperine; PXR, pregnane X receptor; RIF, rifampicin; SRC-1, steroid receptor coactivator-1; TO, T0901317Piperine; Pregnane X receptor;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase

Keywords: PXR، گیرنده حامل X; CAR, constitutive androstane receptor; PXR, pregnane X receptor; RXRα, retinoid X receptor α; DHCR24, 24-dehydrocholesterol reductase; TCPOBOP, 1,4-bis[(3,5-dichloropyridin-2-yl)oxy]benzene; CITCO, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldeh

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice

Keywords: PXR، گیرنده حامل X; CAR, constitutive androstane receptor; PXR, pregnane X receptor; PTU, propylthiouracil; WT, wild type; CYP, cytochrome P450; ND, normal diet; PTU/LI, propylthiouracil/low iodine; T4, tetraiodothyronine; CBZ, carbamazepine; MEM, minimal essential medium; W

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Primary biliary cirrhosis and bile acids

Keywords: PXR، گیرنده حامل X; FXR, Farnesoid X receptor; PBC, Primary biliary cirrhosis; PPARα, peroxisome proliferator-activated receptor alpha; PXR, Pregnane X receptor; UDCA, ursodeoxycholic acid

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Characterization of human cytochrome P450 induction by pesticides

Keywords: PXR، گیرنده حامل X; CYP, Cytochrome P450; PXR, Pregnane X receptor; CAR, Constitutive androstane receptor; XREM, Xenobiotic reponsive enhancer module; LBDs, Ligand-binding domains; AhR, Aryl hydrocarbon receptor; TCPOBOP, 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene; TMPP, Tri

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes

Keywords: PXR، گیرنده حامل X; DEC1, differentially expressed in chondrocytes 1; IL-6, interleukin-6; CYP450, cytochrome P450; PXR, pregnane X receptor; hPXR, human pregnane X receptor; Rif, rifampicin; TNF-α, tumor necrosis factor α; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; PC

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Drug–drug interactions by azole antifungals: Beyond a dogma of CYP3A4 enzyme activity inhibition

Keywords: PXR، گیرنده حامل X; CAR, constitutive androstane receptor; GR, glucocorticoid receptor; HNF4α, hepatocyte nuclear factor 4 alpha; PXR, pregnane X receptor; RXRα, retinoid X receptor alpha; SRC-1, steroid receptor co-activator 1Azoles; Cytochrome CYP3A4; Pregnane X receptor;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells

Keywords: PXR، گیرنده حامل X; CAR, constitutive androstane receptor; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; KTZ, ketoconazole; P-gp, P-glycoprotein; PXR, pregnane X receptor; Rh123, rhodamine 123; RIF, rifampicin; SL, spironolactoneHepG2 cells; Cytotoxicity; P-glycoprotein;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Identification of novel pregnane X receptor activators from traditional Chinese medicines

Keywords: PXR، گیرنده حامل X; PXR, pregnane X receptor; TCM, traditional Chinese medicine; CYP3A4, cytochrome P450 3A4; DMSO, dimethylsulfoxide; RT-PCR, reverse transcriptase-polymerase chain reaction; CAR, constitutive androstane receptor; GR, glucocorticoid receptorTraditional Chine

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Nuclear receptor PXR, transcriptional circuits and metabolic relevance

Keywords: PXR، گیرنده حامل X; CYP, cytochrome P450; DDI, drug–drug interaction; G6Pase, glucose-6-phosphatase; GST, glutathione S-transferase; NR, nuclear receptor; PCN, prenenolone-16α-carbonitrile; PEPCK, phosphoenolpyruvate carboxykinase; PXR, pregnane X receptor; RIF, rifampicin;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes

Keywords: PXR، گیرنده حامل X; PXR, pregnane X receptor; CAR, constitutive activate/androstane receptor; HNF4α, hepatocyte nuclear factor 4α; RE, response element; NCOA6, nuclear receptor coactivator 6 (PRIP/RAP250/ASC-2); PBP, peroxisome proliferator-activated receptor binding protein

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Induction of a detoxification gene in Drosophila melanogaster requires an interaction between tissue specific enhancers and a novel cis-regulatory element

Keywords: PXR، گیرنده حامل X; Xenobiotic; Cytochrome P450; Gene regulation; Tissue specific expression; Midgut; DetoxificationCRE, cis-regulatory element; PB, Phenobarbital; P450, cytochrome 450; PXR, pregnane X receptor; CAR, constitutive androstane receptor; AhR, aryl hydrocarbon re

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Cytochrome P450 is regulated by noradrenergic and serotonergic systems

Keywords: PXR، گیرنده حامل X; CYP, cytochrome P450; AhR, arylhydrocarbon receptor; CAR, constitutive androstane receptor; PXR, pregnane X receptor; GR, glucocorticoid receptor; HPLC, high performance liquid chromatography; DSP-4, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine; PCA, p-ch

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

3,4-Methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition

Keywords: PXR، گیرنده حامل X; CYP450, cytochrome P450; PXR, pregnane X receptor; MDMA, 3,4-methylenedioxymethamphetamine; DZ, diazepam; DPH, phenytoin; CLZ, clozapine; RSP, risperidone; FLX, fluoxetine; PX, paroxetine; mCPP, chlorophenylpiperazine; AP, amphetamine; R, rifampicin; PCN,

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Sex differences in nuclear receptor-regulated liver metabolic pathways

Keywords: PXR، گیرنده حامل X; NRs, nuclear receptors; ER, estrogen receptor; AR, androgen receptor; GR, glucocorticoid receptor; RXR, retinoic X receptor; LXR, liver X receptor; PPAR, peroxisome proliferator activated receptor; TR, thyroid hormone receptor; PXR, pregnane X receptor; C

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1α)-deficient mice

Keywords: PXR، گیرنده حامل X; HNF, hepatocyte nuclear factor; CYP, cytochrome P450; MODY-3, maturity onset diabetes of the young type 3; NIDDM, non-insulin-dependent diabetes mellitus; CAR, constitutive active receptor; PXR, pregnane X receptor; FXR, farnesoid X receptor; c/EBPα and β

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR

Keywords: PXR، گیرنده حامل X; PXR, pregnane X receptor; CYP, cytochrome P450; XRE, xenobiotic response element; SRC, steroid receptor co-activator; ALIS, automated ligand identification system; TdCD, temperature-dependent circular dichroism; Kd, dissociation constant; RXR, retinoic X

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Investigation of Orlistat effects on PXR activation and CYP3A4 expression in primary human hepatocytes and human intestinal LS174T cells

Keywords: PXR، گیرنده حامل X; AhR, aryl hydrocarbon receptor; CAR, constitutive androstane receptor; CYP3A4, cytochrome P450 isoform 3A4; DMSO, dimethylsulphoxide; LS174T, human Caucasian colon adenocarcinoma cell line; ORL, Orlistat; PXR, pregnane X receptor; RIF, rifampicinCytochrom

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Functions and transcriptional regulation of adult human hepatic UDP-glucuronosyl-transferases (UGTs): Mechanisms responsible for interindividual variation of UGT levels

Keywords: PXR، گیرنده حامل X; AhR, Ah receptor; CAR, constitutive androstane receptor; PPAR, peroxisome proliferator-activated receptor; PXR, pregnane X receptor; UGT, UDP-glucuronosyltransferaseHepatic UGTs; Human liver; Interindividual variation; Transcription factors; Xenosensors

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Retinoids activate RXR/CAR-mediated pathway and induce CYP3A

Keywords: PXR، گیرنده حامل X; ALHD, aldehyde dehydrogenases; CYP, cytochrome P450; RA, retinoic acid; All-trans RP, all-trans retinol palmitate; PXR, pregnane X receptor; CAR, constitutive androstane receptor; RXR, retinoid X receptor; mCAR, mouse constitutive androstane receptor; mRX

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes

Keywords: PXR، گیرنده حامل X; ARE, antioxidant responsive element; CAR, constitutive androstane receptor; CYP, cytochrome P450; Nrf2, nuclear factor-erythroid 2-related factor 2; PBREM, Phenobarbital Responsive Enhancer Module; PXR, pregnane X receptor; RXR, retinoid acid X receptorOl

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes

Keywords: PXR، گیرنده حامل X; IL-6, interleukin-6; CYP450, cytochrome P450; PXR, pregnane X receptor; hPXR, human pregnane X receptor; LPS, lipopolysaccharide; TNF-α, tumor necrosis factor α; DRB, 5,6-dichlororibosidyl-benzimidazole; GAPDH, glyceradehyde-3-phosphate dehydrogenase; PCR

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Endocrine disruptors and thyroid hormone physiology

Keywords: PXR، گیرنده حامل X; T3, triiodothyronine; T4, thyroxine; TH, thyroid hormone; TSH, thyrotropin; CAR, constitutive androstane receptor; PPAR, peroxisome proliferator-activated receptors; PXR, pregnane X receptor; RXR, retinoid X receptor; TR, thyroid hormone receptor; N-CoR,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Dexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid esfenvalerate in the induction of cytochrome P450 3A23

Keywords: PXR، گیرنده حامل X; CYP, cytochrome P450; DMEM, Dulbecco's Modified Eagle Medium; GAPDH, glyceradehyde-3-phosphate dehydrogenase; HBSS, Hank's buffered salt solution; ITS, insulin-transferrin-sodium selenite; PXR, pregnane X receptor; RT-qPCR, quantitative reverse transcript

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

The alternatively spliced murine pregnane X receptor isoform, mPXRΔ171–211 exhibits a repressive action

Keywords: PXR، گیرنده حامل X; PXR, pregnane X receptor; CYP, cytochrome P450; MDR1, Multi Drug Resistance Protein 1; P-gp, P-glycoprotein; TSA, trichostatin A; RXR, retinoid X receptor; NR, nuclear receptors; h, human; m, mouse; mRNA, messenger ribonucleic acid; mP1, mPXR431; mP2, mPX

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene

Keywords: PXR، گیرنده حامل X; eNR3A4, essential distal nuclear receptor-binding element for CYP3A4 induction; ER6, everted repeat separated by six nucleotides; prER6, ER6 in the CYP3A4 proximal promoter; DR4, direct repeat separated by four nucleotides; PXR, pregnane X receptor; RE, r

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4α

Keywords: PXR، گیرنده حامل X; CAR, nuclear constitutive active/androstane receptor; PXR, pregnane X receptor; CYP, cytochrome P450; EGR1, early growth response 1; HNF4α, hepatocyte-enriched nuclear factor 4α; OAREKI, OA response element KI; PB, phenobarbital; PBREM, PB responsive enha

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA

Keywords: PXR، گیرنده حامل X; PXR, pregnane X receptor; CAR, constitutive androstane receptor; GR, glucocorticoid receptor; PXRE, PXR response element; hPXR, human PXR; PCR, polymerase chain reaction; wt, wild-typeCryptotanshinone; Tanshinone IIA; PXR; CYP3A4; Induction

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression

Keywords: PXR، گیرنده حامل X; MDR, multidrug resistance; P-gp, P-glycoprotein; PXR, Pregnane X Receptor; PBS, phosphate-buffered saline; DMSO, dimethyl sulfoxide.Piperine; P-gp; MDR1; Digoxin transport

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced downregulation of CYP3A in fetal liver: Its repression by a low dose LPS pretreatment

Keywords: PXR، گیرنده حامل X; CYP, cytochrome; ELISA, enzyme-linked immunosorbent assay; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; LPS, lipopolysaccharide; PXR, pregnane X receptor; PTX, pentoxifylline; RT-PCR, reverse transcription polymerase chain reaction; TNF, tumor necrosi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation

Keywords: PXR، گیرنده حامل X; CAR, constitutive androstane receptor; CDK, cyclin-dependent kinase; PXR, pregnane X receptor; RXR, retinoid X receptor; UGT, UDP-glucuronosyltransferaseCAR; CDK4; MDM2; Cell proliferation; HGF; UGT1A1

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Dexamethasone suppresses the expression of multiple rat carboxylesterases through transcriptional repression: Evidence for an involvement of the glucocorticoid receptor

Keywords: PXR، گیرنده حامل X; AGP, α-1 acid glycoprotein; CYP, cytochrome P450; HA, hydrolase A; HB, hydrolase B; HS, hydrolase S; MEME, minimum essential medium eagle; GAPDH, glyceradehyde-3-phosphate dehydrogenase; HCE, human carboxylesterases; PXR, pregnane X receptor; RT-qPCR, qua

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy

Keywords: PXR، گیرنده حامل X; RT-PCR, real time PCR; RAR, retinoic acid receptor; RXR, retinoid X receptor; HNF, hepatic nuclear factor; PXR, pregnane X receptor; CAR, constitutive androstane receptor; PBS, phosphate buffered saline; TE, tris-EDTA(8) Pharmacokinetics; Drug metabolismL

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Phenobarbital suppresses vitamin D3 25-hydroxylase expression: A potential new mechanism for drug-induced osteomalacia

Keywords: PXR، گیرنده حامل X; CYP, cytochrome P450; CYP27A1, mitochondrial sterol 27-hydroxylase/vitamin D3 25-hydroxylase; CAR, constitutive androstane receptor; PXR, pregnane X receptor; RXR, retinoid X receptor; RLU, relative light unitsBioactivation of vitamin D3; 25-Hydroxylation

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: The role of a gene enhancer in the liver chromatin

Keywords: PXR، گیرنده حامل X; PCN, pregnenolone-16α-carbonitrile; D3, 1α,25-dihydroxy vitamin D3; IR0, inverted repeat-zero spacer; VDR, vitamin D receptor; PXR, pregnane X receptor; RXR-α, retinoid X receptor α; CAR, constitutive androstane receptor; ChIP, chromatin immunoprecipitati

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه