Cardiac effects of sertindole and quetiapine: Analysis of ECGs from a randomized double-blind study in patients with schizophrenia
Keywords: T-wave; Morphology; QT; QTc; SCD;
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Cardiohemodynamic and electrophysiological effects of a selective EP4 receptor agonist ONOÂ-AE1Â-329 in the halothane-anesthetized dogs
Keywords: AH; atrio-His; ANOVA; analysis of variance; EMc; electro-mechanical coupling; EMw; electro-mechanical window; EP1, 2, 3 and 4; prostaglandin E2 type 1, 2, 3 and 4; HV; His-ventricular; LVdP/dtmax; maximum upstroke velocity of the left ventricular pressure
Cardiac late Na+ current: Proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress
Keywords: AP; action potential; APD; action potential duration; ATX-II; anemone toxin II; [Ca2+]i; intracellular calcium concentration; CaMKII; Ca2+/calmodulin-dependent protein kinase II; DAD; delayed afterdepolarization; EAD; early afterdepolarization; ICa-L; L-t
Contrasting cardiovascular properties of the µ-opioid agonists morphine and methadone in the rat
Keywords: ECG; electrocardiogram; HR; heart rate; KPSS; isotonic potassium physiological salt solution; MAP; mean arterial pressure; NO; nitric oxide; NOS; nitric oxide synthase; pEC50; the negative log10 of agonist concentration that caused 50% of the maximum resp
Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current
Keywords: AP; action potential; APD; action potential duration; ECG; electrocardiogram; IK1; inward rectifier potassium current; IKur; ultrarapid delayed rectifier potassium current; INa; sodium current; Iss; sustained potassium current; Ito; transient outward pota
Corrected QT Changes During Antipsychotic Treatment of Children and Adolescents: A Systematic Review and Meta-Analysis of Clinical Trials
Keywords: adolescents; antipsychotics; children; ECG; QTc;
Preliminary Results of Bedaquiline as Salvage Therapy for Patients With Nontuberculous Mycobacterial Lung Disease
Keywords: AFB; acid-fast bacilli; Mab; Mycobacterium abscessus; MAC; Mycobacterium avium complex; MDR-TB; multidrug-resistant TB; MTB; Mycobacterium tuberculosis; NTM; nontuberculous mycobacterial; QTc; corrected QT; TIW; three times weekly; UTHSCT; University of T
The cardiomyocyte molecular clock regulates the circadian expression of Kcnh2 and contributes to ventricular repolarization
Keywords: ECG; electrocardiographic; BMAL1; brain muscle arnt-like1; CLOCK; circadian locomotor output control kaput; iCSÎBmal1; inducible cardiomyocyte-specific deletion of Bmal1; IKr; rapidly activating delayed-rectifier K+ current; Klf15; Krüppel-like factor 1
Consistency of heart rate-QTc prolongation consistency and sudden cardiac death: The Rotterdam Study
Keywords: CI; confidence interval; ECG; electrocardiogram; HR; hazard ratio; MEANS; modular ECG analysis system; QTc; heart rate-corrected QT interval; QTcB; heart rate-corrected QT interval according to the Bazett formula; QTcF; heart rate-corrected QT inter
Clinical PotpourriCorrected QT-interval prolongation and variability in intensive care patients
Keywords: QTc; Prolongation; Variability; Continuous; Monitoring; ECG;
New formula for evaluation of the QT interval in patients with left bundle branch block
Keywords: JTb; paced JT interval; JTi; intrinsic JT interval; LBBB; left bundle branch block; QRSb; paced QRS interval; ÎQT; paced QT interval minus intrinsic QT interval; QTb; paced QT interval; QTc; corrected QT interval using the Bazett formula; QTm; modified Q
Viewpoint: PointRationale and objectives for ECG screening in infancy
Keywords: ECG; electrocardiographic/electrocardiogram; LQTS; long QT syndrome; QTc; corrected QT; SCD; sudden cardiac death; SIDS; sudden infant death syndrome; ECG screening; Infants; Long QT syndrome; Sudden cardiac death;
Oral contraceptive use and the risk of cardiac events in patients with long QT syndrome
Keywords: ACA; aborted cardiac arrest; CE; cardiac event; HR; hazard ratio; IKr; rapid component of cardiac K+ channel; IKs; slow component of cardiac K+ channel; LQTS; long QT syndrome; LQT#; long QT syndrome genotype #; OC; oral contraceptive; PWP; Prentice-Willi
Single nucleotide polymorphisms in arrhythmia genes modify the risk of cardiac events and sudden death in long QT syndrome
Keywords: CI; confidence interval; ECG; electrocardiogram; GWAS; genome wide association study; HR; hazard ratio; LQT1; long QT syndrome type 1; LQT2; long QT syndrome type 2; LQT3; long QT syndrome type 3; LQTS; long QT syndrome; NZ; New Zealand; OR; odds ratio; Q
Induced KCNQ1 autoimmunity accelerates cardiac repolarization in rabbits: Potential significance in arrhythmogenesis and antiarrhythmic therapy
Keywords: ANOVA; analysis of variance; AP; action potential; APD; action potential duration; BCL; basic cycle length; DCM; dilated cardiomyopathy; IgG; immunoglobulin G; LQT; long QT; LV; left ventricle; QTc; corrected QT interval duration; SCD; sudden cardiac deat
Genetic Variants for Long QT Syndrome among Infants and Children from a Statewide Newborn Hearing Screening Program Cohort
Keywords: bpm; Beats/min; ECG; Electrocardiogram; JLNS; Jervell and Lange-Nielsen syndrome; LQTS; Long QT syndrome; NHSP; Newborn Hearing Screening Program; QTc; Heart rate corrected QT; SNHL; Sensorineural hearing loss;
A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation
Keywords: AKAP9; A-kinase anchoring protein 9 (Yotiao); AP; action potential; APD90; steady-state action potential duration at 90% repolarization; ECG; electrocardiogram/electrocardiographic; HEK293; human embryonic kidney 293; IKs; slowly activating delayed rectif
Association of the Frontal QRS-T Angle with Adverse Cardiac Remodeling, Impaired Left and Right Ventricular Function, and Worse Outcomes in Heart Failure with Preserved Ejection Fraction
Keywords: QRS-T angle; Diastolic heart failure; Echocardiography; Outcomes; BNP; B-type natriuretic peptide; HF; Heart failure; HFpEF; Heart failure with preserved ejection fraction; LV; Left ventricular; LVEF; Left ventricular ejection fraction; QTc; Corrected QT;
Perioperative Doses of Ondansetron or Dolasetron Do Not Lengthen the QT Interval
Keywords: ASA; American Society for Anesthesiologists; BMI; body mass index; ECG; electrocardiogram; FDA; Food and Drug Administration; 5HT3R; serotonin-3 receptor; MAC; minimum alveolar concentration; PACU; postanesthesia care unit; QTc; rate-corrected QT electroc
Novel deletion mutation in the cardiac sodium channel inactivation gate causes long QT syndrome
Keywords: AV block; Atrio-ventricular block; Bpm; Beats per minute; BrS; Brugada syndrome; CCD; Cardiac conduction defects; ECG; Electrocardiogram; HR; Heart rate; ICD; Implantable cardioverter defibrillator; K; Slope factor; LQTS; Long QT syndrome; QTc; QT interva
Myocardial fibrosis and QTc are reduced following treatment with spironolactone or amiloride in stroke survivors: A randomised placebo-controlled cross-over trial
Keywords: Myocardial fibrosis; QTc; Stroke; Spironolactone; Amiloride;
Prognostic implications of mutation-specific QTc standard deviation in congenital long QT syndrome
Keywords: CI; confidence interval; ECG; electrocardiogram/electrocardiographic; HR; hazard ratio; LQTS; long QT syndrome; LQT2; long QT syndrome type 2; QTc; corrected QT interval; QTcSD; QTc standard deviation; SNP; single nucleotide polymorphism; Long QT syndrome
A public-private consortium advances cardiac safety evaluation: Achievements of the HESI Cardiac Safety Technical Committee
Keywords: ADRs; adverse drug reactions; CDER; Center for Drug Evaluation and Research; cTn; cardiac troponin; CV; cardiovascular; EMA; European Medicines Agency; EWG; Expert Working Group; ECG; electrocardiogram; HESI; Health and Environmental Sciences Institute; h
Mechanism and diagnostic potential of reciprocal ECG changes induced by acute coronary artery occlusion in pigs
Keywords: ECG; electrocardiogram; LAD; left anterior descending; LV; left ventricle/ventricular; QTc; corrected QT interval; RC; right coronary; Myocardial ischemia; Coronary occlusion; Reciprocal ECG changes; In situ heart; Isolated perfused heart; Pigs;
Long-Term Follow-Up of a Pediatric Cohort With Short QT Syndrome
Keywords: arrhythmias; atrial fibrillation; short QT syndrome; sudden cardiac death; ECG; electrocardiography; ICD; implantable cardioverter-defibrillator; IQR; interquartile range; QTc; corrected QT interval for heart rate using the Bazett formula; SCD; sudden car
Voltage-gated Ca2+ influx and mitochondrial Ca2+ initiate secretion from Aplysia neuroendocrine cells
Keywords: ATP; adenosine triphosphate; Ba2+-Cs+-TEA ASW; Ba2+, Cs+ tetraethylammonium artificial sea water; Baf; bafilomycin A; Ca2+-Cs+-TEA ASW; Ca2+, Cs+ tetraethylammonium artificial sea water; cfASW; Ca2+-free artificial salt water; Cm; membrane capacitance; Cn
Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: Discovery of DS-8108b, an orally active renin inhibitor
Keywords: HR; heart rate; PR; PR interval; QRS; QRS width; QTc; corrected QT interval; Renin inhibitor; Ketopiperazine; Plasma renin activity; Hypertension; Na channel;
A case of long QT syndrome with triple gene abnormalities: Digenic mutations in KCNH2 and SCN5A and gene variant in KCNE1
Keywords: ECG; electrocardiogram; LQTS; long QT syndrome; PAS; Per-Arnt-Sim; QTc; corrected QT interval; QTcb; QTc rectified using Bazett's formula; Digenic mutation; Compound mutation; KCNH2; SCN5A; KCNE1; molecular screening;
Benthic habitat mapping of sorted bedforms using hydroacoustic and ground-truthing methods in a coastal area of the German Bight/North Sea
Keywords: macrofauna; sediment type; community structure; hydroacoustic; QTC; island of Sylt
Can prolonged QTc and cTNT level predict the acute and long-term prognosis of stroke?
Keywords: QTc; Repolarization time; Troponin; cTNT; Stroke prognosis;
Congenital type 1 long QT syndrome unmasked by a highly caffeinated energy drink
Keywords: Long QT syndrome; Energy drink; bpm; beats per minute; ECG; electrocardiogram; ED; emergency department; LQT1; long QT type 1; LQTS; long QT syndrome; QTc; corrected QT interval;
The use of serum bepridil concentration as a safe rhythm control strategy in patients with atrial tachyarrhythmias
Keywords: Serum concentration; Atrial tachyarrhythmia; QT interval; QTc; Proarrhythmia
Beta adrenergic blockade prevents cardiac dysfunction following status epilepticus in rats
Keywords: Myocardial stunning; Self sustaining limbic status epilepticus; QTc; Cardiac output; dP/dt
Prolongation of QTc and Risk of Stroke : The REGARDS (REasons for Geographic and Racial Differences in Stroke) Study
Keywords: electrocardiogram; QTc; REGARDS; stroke riskAF, atrial fibrillation; CI, confidence interval; CVD, cardiovascular disease; ECG, electrocardiographic; HR, hazard ratio; LVH, left ventricular hypertrophy; QTc, QT interval corrected for heart rate; QTcBaz, Q
Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo
Keywords: Short-term variability; Torsades de pointes; Chronic AV block dog; Drugs; Long QT syndrome; Repolarization; Biomarkers; APD; action potential duration; BVR; beat-to-beat variability of repolarization; cAVB; chronic atrioventricular block; ECG; electrocard
5 HT3-receptor antagonists and cardiac repolarization time in patients expressing a novel genetic target associated with baseline QTc interval abnormalities
Keywords: QT; QTc; 5 HT3-receptor antagonist; NOSA1P; SNP rs10494366; Postoperative nausea; PONV
Apical Hypertrophic Cardiomyopathy: Prevalence and Correlates of Apical Outpouching
Keywords: Apical aneurysm; Apical hypertrophic cardiomyopathy; Apical outpouching; Echocardiography; Ischemia; ApHCM; Apical hypertrophic cardiomyopathy; HCM; Hypertrophic cardiomyopathy; LV; Left ventricular; MRI; Magnetic resonance imaging; QTc; Corrected QT;
Electrocardiographic and oximetric changes during partial complex and generalized seizures
Keywords: Epilepsy; Hypoxemia; Tachycardia; QTc; SUDEP;
Assessing electrocardiographic data quality and possible replacement of pharmacologic positive control in thorough QT/QTc studies by investigations of drug-free QTc stability
Keywords: ECG measurement; Measurement reproducibility; Measurement stability; Positive control; QTc interval; Thorough QT study; CI; confidence interval; QTc; corrected QT interval; SD; standard deviation; TQTS; thorough QT/QTc study;
Pharmacokinetic–pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys
Keywords: Dofetilide; Cynomolgus monkey; Moxifloxacin; PKPD; QTc; QT interval
The role of the autonomic system in rate-dependent repolarization changes
Keywords: Autonomic modulation; Ventricular repolarization; Heart rate; Rate dependency; Species specificity; AP; action potential; APD; action potential duration; βAR; beta-adrenergic receptors; CL; cycle length; MAP; monophasic action potential; QT; electrocardi
Assessment of ECG interval and restitution parameters in the canine model of short QT syndrome
Keywords: Dog; QT; QTc; Restitution; Short QT; Sling-trained
Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus
Keywords: Seizures; Sudden cardiac death; Kv4.x potassium channels; Troponin; QTc; QTcd
Influencing factors of QTc among the clinical characteristics in type 2 diabetes mellitus
Keywords: QTc; Diabetic neuropathy; Sex difference; Hypertension; Diabetic retinopathy;
Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in a guinea pig model of Andersen-Tawil syndrome
Keywords: Arrhythmia mechanism; Cellular calcium; Mapping; Repolarization; Ventricular arrhythmia; APD; action potential duration; APD50; 50% of action potential duration; ATS1; Anderson-Tawil syndrome; BCL; basic cycle length; Ca2+; calcium; [Ca2+]i; cytosolic Ca2
ECG alteration due to prolong exposure to natural gas leakage containing sulfur compounds in polluted areas of Masjid-I-Sulaiman (south of Iran)
Keywords: Sulfur compounds; QTc; PR interval; R amplitude; QRS complex
Sertindole causes distinct electrocardiographic T-wave morphology changes
Keywords: T-wave; Sertindole; Antipsychotics; QTc; Sudden death; Torsade de pointes
Reversal of Cardiac Dysfunction after Enzyme Replacement in Patients with Infantile-Onset Pompe Disease
Keywords: BNP; B-type natriuretic peptide; ECG; Electrocardiogram; ERT; Enzyme replacement therapy; GAA; Acid-α glucosidase; LV; Left ventricular; LVEF; Left ventricular ejection fraction; LVMI; Left ventricular mass index; NBS; Newborn screening; QTc; Corrected Q
Models of torsades de pointes: Effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts
Keywords: STV; short-term variability; Tp-Te; peak to end of T-wave; QTc; corrected QT interval; Chromanol 293B; Dofetilide; DPI201106; FPL64176; IKs; Langendorff; Torsades; QTc; Short-term variability;
Longitudinal ECG changes in cocaine users during extended abstinence
Keywords: Cocaine; ECG; Withdrawal; QTc; Longitudinal; Abstinence