Novel 2-(substituted benzyl)quinuclidines inhibit human α7 and α4β2 nicotinic receptors by different mechanisms
Keywords: nAChR; nicotinic acetylcholine receptor; ACh; acetylcholine; CCh; carbamylcholine; [3H]MLA; [3H]methyllycaconitine; RT; room temperature; IC50; ligand concentration that produces 50% inhibition (of binding or of agonist activation); Ki; inhibition constan