Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa
Keywords: Pol; DNA polymerase; TLS; translesion DNA synthesis; dG; N2-deoxyguanosine; BP; benzo[a]pyrene; BPDE; benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide; (+)-BPDE-N2-dG; (+)-trans-anti-BPDE-N2-dG; (â)-BPDE-N2-dG; (â)-trans-anti-BPDE-N2-dG; F171; phenylalanin