Tumor cell migration and invasion are regulated by expression of variant integrin glycoforms
Keywords: Ras; Integrin; Sialic acid; Metastasis; Collagen; Colonocytes;
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Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors
Keywords: Bisphosphonate; Geranylgeranyl diphosphate; Geranylgeranyl diphosphate synthase; Ras; Rap1a; Prenylation; Geranylgeranylation; Farnesyl diphosphate; Farnesylation
Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3
Keywords: Mitogen activated protein kinase phosphatase-3; Extracellular signal regulated kinase; Ras
Oncogenic potential of BRAF versus RAS
Keywords: BRAF; RAS; p53;
Many faces of Ras activation
Keywords: Ras; Sos; RasGRF; RasGRP; CNrasGEF
The growth of disk abalone, Haliotis discus hannai at different culture densities in a pilot-scale recirculating aquaculture system with a baffled culture tank
Keywords: Abalone; Haliotis discus hannai; RAS; Growth; Water quality; Energy consumption
Tissue-specific functions of the Caenorhabditis elegans p120 Ras GTPase activating protein GAP-3
Keywords: Ras; GTPase; GAP; Tumor; Suppressor;
Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats
Keywords: NAFLD; non-alcoholic fatty liver disease; RAS; renin-angiotensin system; Ang II; Angiotensin II; Ren2; transgenic TG(mRen2)27(Ren2) rat; SD; Sprague-Dawley rat; NASH; non-alcoholic steatohepatitis; ROS; reactive oxygen species; ACE; angiotensin-conver
Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells
Keywords: AMP-activated protein kinase (AMPK); Berberine; Cdc42; Cyclin-dependent kinase (Cdk); Cyclin D1/D3; Platelet-derived growth factor (PDGF); Rac1; Ras; Vascular smooth muscle cell (VSMC)
The budding yeast RasGEF Cdc25 reveals an unexpected nuclear localization
Keywords: Saccharomyces cerevisiae; Nucleus; Ras
Distribution of somatostatin immunoreactive neurons and fibres in the central nervous system of a chondrostean, the Siberian sturgeon (Acipenser baeri)
Keywords: AC; anterior commissure; AP; area postrema; AU; auricula cerebelli; CB; corpus cerebelli; CC; central canal; cg; central grey; CP; choroid plexus; Dc; central part of the dorsal telencephalon; Dd+Dl; dorsal and lateral parts of the dorsal telencephalon; D
SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1
Keywords: T cell antigen receptor; AP-1; Ras; Signaling; CD3; T lymphocytes;
The Rsu-1-PINCH1-ILK complex is regulated by Ras activation in tumor cells
Keywords: Rsu-1; PINCH1; Integrin-linked kinase; Adhesion; Ras; Focal adhesion; Migration
Molecular pathology of thyroid cancer: diagnostic and clinical implications
Keywords: thyroid cancer; pathogenesis; oncogene; RET; BRAF; RAS; molecular diagnostics; PTEN; PI3 kinase
Receptor-mediated tobacco toxicity: Alterations of the NF-κB expression and activity downstream of α7 nicotinic receptor in oral keratinocytes
Keywords: Nicotinic acetylcholine receptors; Gene expression; NF-κB; Ras; Raf; ERK; MEK
Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: An angiotensin II type 2 receptor-mediated effect
Keywords: AngII, angiotensin II; AT1-receptor, angiotensin II type 1 receptor; AT2-receptor, angiotensin II type 2 receptor; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; MMP, matrix metalloproteinaseAtherosclerosis; Cathepsins; Proteolysis; RAS
A co-localization assay for the analysis of protein–protein interactions
Keywords: Grb2, growth factor receptor binding protein 2; TEV, tobacco etch virus; SOS, son-of-sevenless; cAMP, cyclic adenosine monophosphate; TPS, TEV protease substrate; OD, optical density.Yeast; Cdc25; Ras; Site-specific protease; Recruitment
Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase
Keywords: Bisphosphonate; Geranylgeranyl pyrophosphate synthase; Farnesyl pyrophosphate synthase; Isoprenoid; Mevalonate; Prenylation; Ras; Zoledronate; Digeranyl bisphosphonate
Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells
Keywords: Necl-5; Tage4; Poliovirus receptor; CD155; Nectin; Cell movement; Cell proliferation; Contact inhibition; Ras; TransformationNecl, nectin-like molecule; Nef, the fusion protein containing the extracellular region of nectin fused to the Fc portion of human
Fibrolamellar carcinomas show overexpression of genes in the RAS, MAPK, PIK3, and xenobiotic degradation pathways
Keywords: Fibrolamellar carcinoma; RAS; MAPK; PIK3; Xenobiotic degradation pathways; Chromosome 1q
Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors
Keywords: Renin inhibitor; Hypertension; 2,4-Diaminopyrimidine; Structure based drug design; Renin–angiotensin system; RAS; Conformational overlap; Scaffold hopping
Expression of estrogen induced gene 121-like (EIG121L) during early Xenopus development
Keywords: Xenopus laevis; Estrogen induced gene 121; EIG121L; Ras; Hatching gland; Cement gland; Eye; Otic vesicle; Olfactory pit; Primary mouth
Geranylgeranylacetone inhibits ovarian cancer progression in vitro and in vivo
Keywords: LPA, lysophosphatidic acid; GGA, geranylgeranylacetone; GGOH, geranylgeraniol; FOH, farnesol; ROCK, Rho-associated kinaseGeranylgeranylacetone; Lysophosphatidic acid; Rho; Ras; Geranylgeranylation; Ovarian cancer
The GAP-related domain of neurofibromin attenuates proliferation and downregulates N- and K-Ras activation in Nf1-negative AML cells
Keywords: GAP-related domain; Neurofibromin; Myeloid leukemia; Ras
Cutting Balloon Angioplasty in Children with Resistant Renal Artery Stenosis
Keywords: CBA; cutting balloon angioplasty; PTRA; percutaneous transluminal renal angioplasty; RAS; renal artery stenosis;
In vitro transformation of mesenchymal stem cells by oncogenic H-rasVal12
Keywords: Mesenchymal stem cell; TERT; Bmi1; ras; Transformation; Autophagy; Differentiation
Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity
Keywords: Ovarian cancer; Trophinin; Ras; Chemosensitivity
Ras Pathway Activation in Malignant Mesothelioma
Keywords: Ras; Mesothelioma; Translation; Cap dependent; Eukaryotic initiation factor 4E; Eukaryotic initiation factor 4E
Elevated small GTPase activation influences the cell proliferation signaling control in Niemann–Pick type C fibroblasts
Keywords: Niemann–Pick type C; RhoA; Ras; Cyclin D; p21/waf1
A novel approach based on nanotechnology for investigating the chronic actions of short-lived peptides in specific sites of the brain
Keywords: Liposomes; Angiotensin-(1–7); Angiotensin II; RVLM; RAS
Fetal functional capabilities in response to maternal hypertonicity associated with altered central and peripheral angiotensinogen mRNA in rats
Keywords: Osmoregulation; Fetal development; RAS
Erk pathways negatively regulate matrix mineralization
Keywords: Mineralization; Osteocyte; Osteoblast; Erk; Ras; Mek
Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase
Keywords: Membrane traffic; Rab45; RASEF; Rab; Ras; Small GTPase; EF-hand; Coiled-coil; Oligomerization
Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts
Keywords: ras; ras-GAP; Gap1m; Expression; MEK; Doxorubicin; Trichostatin A
MR Imaging Assessment of Changes in Renal Function with Renal Artery Stent Placement in Swine
Keywords: DSA; digital subtraction angiography; EF; ejection fraction; GFR; glomerular filtration rate; PC; phase-contrast; PTA; percutaneous transluminal angioplasty; RAS; renal artery stenosis; RBF; renal blood flow; skGFR; single-kidney glomerular filtration rat
Inhibitors of Raf kinase and MEK signaling
Keywords: Target; RAS; RAF; MEK; ERK; Signal; Transduction; Inhibitors
Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1
Keywords: Ras; Rap1; Flagellin; LPS; Toll-like receptors; Chickens; Heterophils; Innate immunity; Signal transduction
H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A
Keywords: 3T3-L1 cells; Adipogenesis; H-89; Protein kinase A; Rho kinase; Phosphoinositide 3-kinase; Akt; Ras; Extracellular signal-regulated kinase 1/2
Suppressive effect of a novel water-soluble artemisinin derivative SM905 on T cell activation and proliferation in vitro and in vivo
Keywords: SM905; Artemisinin derivative; Immunosuppression; T cell activation and proliferation; MAP kinase; Ras
Neural induction in the absence of organizer in salamanders is mediated by MAPK
Keywords: Ambystoma maculatum; Xenopus; Ras; MAPK; ERK; BMP; FGF; Brain differentiation; Smad1; Embryonic induction
Single molecule FRET for the study on structural dynamics of biomolecules
Keywords: Single molecule FRET; DNA; Ras
Role of the arginine finger in Ras·RasGAP revealed by QM/MM calculations
Keywords: Ras; Ras·RasGAP; GTP hydrolysis; Arginine finger; QM/MM; Electrostatic catalysis
Identification of Rgl3 as a potential binding partner for Rap-family small G-proteins and profilin II
Keywords: Rgl3; Rap; Ras; Profilin II
Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction
Keywords: Neuronal differentiation; PC12 cell; Rit; GTPase; Ras; ERK MAP kinase; Par6
Genetically attenuated P36p-deficient Plasmodium berghei sporozoites confer long-lasting and partial cross-species protection
Keywords: Malaria; Plasmodium; Sporozoites; RAS; GAS; Vaccine;
Ras nanoclusters: Molecular structure and assembly
Keywords: DMPC; 1,2-dimyristoyl-sn-glycero-3-phosphocholine; EM; electron microscopy; FCS; fluorescence correlation spectroscopy; FRAP; fluorescence recovery after photobleaching; FRET; fluorescence resonance energy transfer; MβCD; methyl-β-cyclodextrin; MD; mole
Development of the composite RAS (radar absorbing structure) for the X-band frequency range
Keywords: Free space method; Carbon black; RAS; Polymeric composite
The role of Ras signaling in lupus T lymphocytes: Biology and pathogenesis
Keywords: T lymphocyte; Systemic lupus erythematosus; Ras; T cell receptor; Farnesylation; RasGRP1; CAPRI; Erk; PI 3-K
Empirical rules facilitate the search for binding sites on protein surfaces
Keywords: Proteins; Enzymes; Binding sites; Docking; Lipinski's rule-of-five; RO5; Lysozyme; Ras; Ras–Raf interaction; Inhibition; Drugs; Lead compounds
Laminating rule for predicting the dielectric properties of E-glass/epoxy laminate composite
Keywords: Permittivity; Polymeric composite; RAS; Free space method; Laminating rule