Keywords: میکروسوم کبد موش; GSH; glutathione; LC/MS; liquid chromatography/mass spectrometry; MRM; multiple reaction monitoring; HRMS; high resolution mass spectrometry; Qtrap; triple quadrupole linear ion trap; EMS; enhanced MS; NL; neutral loss scan; PI; precursor ion scan; MIM; m
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Keywords: میکروسوم کبد موش; Liquid chromatography–mass spectrometry; Rat liver microsome; Designer drug; Metabolism
Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of Glibenclamide in rat: An herb-drug interaction study
Keywords: میکروسوم کبد موش; TC; Tinospora cordifolia; TCE; Tinospora cordifolia extract; CYP; Cytochrome P450; CAM; complementary and alternative medicine; IS; internal standard; LLOQ-QC; quality control sample at lowest limit of quantification level; LQC; low quality control sample
Herb-drug interaction potential of Berberis aristata through cytochrome P450 inhibition assay
Keywords: میکروسوم کبد موش; CYP450; cytochrome P450; HTS; high-throughput screening; IC50; the 50% inhibitory concentration; RP-HPLC; reverse phase high-performance liquid chromatography; CYP450-CO; cytochrome P450- carbon monoxide; RLM; rat liver microsome; CI; combination index; H
Identification of cytochrome P450 isoforms involved in the metabolism of Syl930, a selective S1PR1 agonist acting as a potential therapeutic agent for autoimmune encephalitis
Keywords: میکروسوم کبد موش; Syl930; Hydroxylated metabolites; CYP450 isoforms; Metabolism; LC-MS/MS; CYPs; cytochrome P450 isoforms; LM; liver microsome; HLM; human liver microsome; RLM; rat liver microsome; MS; multiple sclerosis; S1PRs; sphingosine-1-phosphate receptors; S1PR1; sp
An integrated strategy for the quantitative analysis of endogenous proteins: A case of gender-dependent expression of P450 enzymes in rat liver microsome
Keywords: میکروسوم کبد موش; Cytochrome P450s; Gender difference; Rat liver microsome; Standard curve slope;
The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement
Keywords: میکروسوم کبد موش; NaV1.7; voltage gated sodium channel 1.7; SCN9A; sodium voltage-gated channel alpha subunit 9; TM; transmembrane; VSD; voltage sensing domain; CLu; unbound clearance; HLM; human liver microsome; RLM; rat liver microsome; PX; patch express; LLE; ligand lip
A simple and sensitive UHPLC-Q-TOF-MS/MS method for sophoricoside metabolism study in vitro and in vivo
Keywords: میکروسوم کبد موش; Sophoricoside; UHPLC-Q-TOF-MS/MS; Metabolism; In vivo; Rat liver microsome;
Flavokawain A inhibits Cytochrome P450 in in vitro metabolic and inhibitory investigations
Keywords: میکروسوم کبد موش; FKA, Flavokawain A; CYP450, Cytochrome P450Flavokawain A; Cytochrome P450; Metabolism; Rat liver microsome; Molecular docking
Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC-MS/MS method determines its turnover number and correlates with its glucuronidation activities
Keywords: میکروسوم کبد موش; UGT; uridine 5â²-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase); CYP; cytochrome P450; UPLC; ultra performance liquid chromatography; MRM; multiple reaction monitoring; DP; declustering potential; CE; collision energy; CXP; collision cel
Identification of in vivo and in vitro metabolites of triptolide by liquid chromatography-tandem mass spectrometry
Keywords: میکروسوم کبد موش; Triptolide; LC-MSn; Rat liver microsome; Rat intestinal flora; Metabolite;
Quantitative shot-gun proteomics and MS-based activity assay for revealing gender differences in enzyme contents for rat liver microsome
Keywords: میکروسوم کبد موش; Rat liver microsome; Stable-isotope dimethyl labelling; Sex-dependent enzyme expression; MRM; Enzyme activity assay;
Metabolism of sanguinarine in human and in rat: Characterization of oxidative metabolites produced by human CYP1A1 and CYP1A2 and rat liver microsomes using liquid chromatography–tandem mass spectrometry
Keywords: میکروسوم کبد موش; Sanguinarine; Metabolism; Rat liver microsome; Human CYP1A; LC–MS/MS
Prediction of phospholipidosis-inducing potential of drugs by in vitro biochemical and physicochemical assays followed by multivariate analysis
Keywords: میکروسوم کبد موش; Drug-induced phospholipidosis; Cationic amphiphilic drug; Principal component analysis; Phospholipid vesicle; Rat liver microsome; Phospholipase A2; pKa; Partition coefficient
Neutral and polar lipid metabolism in liver microsomes of growing rats fed a calcium-deficient diet
Keywords: میکروسوم کبد موش; CaD; calcium-deficient; CHO; cholesterol; CHOE; cholesterol esters; CL; cardiolipine; DAG; diacylglycerides; EGTA; ethyleneglycol-bis(β-aminoethyl ether)N,Nâ²-tetraacetic acid; GLC; gas-liquid chromatography; HPLC; high performance liquid chromatograp