Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2)
Keywords: Chemokine CC receptor subtype 2 (CCR2) antagonists; Oxa-Pictet–Spengler reaction; Ethylene sulfate; Appel reaction; Polymer-bound triphenylphosphine; Spirocyclic piperidines; Receptor binding studies; Ca2+ flux; β-Arrestin recruitment; Structure–activity-