
Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis
Keywords: MTX, methotrexate; 7-OHMTX, 7-hydroxymethotrexate; IC50, the drug concentration inhibiting cell growth by 50%; DHFR, dihydrofolate reductase; TS, thymidylate synthase; RFC, reduced folate carrier; FPGS, folylpolyglutamate synthetase; FPGH, folylpolyglutam