Use of physiologically based kinetic modelling-facilitated reverse dosimetry to convert in vitro cytotoxicity data to predicted in vivo liver toxicity of lasiocarpine and riddelliine in rat
Keywords: ریدلین; Physiologically based kinetic (PBK) model; Lasiocarpine; Riddelliine; Liver toxicity; In vitro-in vivo extrapolation; Reverse dosimetry; BMDL5-BMDU5; lower/upper limit of the 90% confidence interval of the benchmark dose that gives a 5% response; BMDL10;