Keywords: روفلومیلاست; NCT01433666; EudraCT2011-002070-23; Roflumilast; PDE4; cAMP; Memory; Verbal learning task;
مقالات ISI روفلومیلاست (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
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Keywords: روفلومیلاست; Dry powder inhaler; Spray drying; Roflumilast; Hydroxypropyl-β-cyclodextrin; Pulmonary delivery;
Keywords: روفلومیلاست; Phosphodiesterase; Cough reflex; PDE inhibitors; Antitussive; Theophylline; Roflumilast;
Keywords: روفلومیلاست; Phosphodiesterase inhibitor; Roflumilast; Chronic cerebral hypoperfusion; Memory;
Keywords: روفلومیلاست; Prescription drugs; Benefit-harm assessment; Pharmacoepidemiology; Roflumilast; Patient preferences; Prescription drug regulation;
Keywords: روفلومیلاست; Hypertension; Rolipram; Roflumilast; Roflumilast N-oxide; Cognition
Keywords: روفلومیلاست; Chronic obstructive pulmonary disease; Roflumilast; Efficacy; Safety; Meta-analysis;
Keywords: روفلومیلاست; Enfermedad pulmonar obstructiva crónica; Roflumilast; Indacaterol; Bromuro de aclidinio; Bromuro de glicopirronio;
Keywords: روفلومیلاست; Phosphodiesterase 4 inhibitors; Roflumilast; COPD phenotypes; Gene transactivation; Combination therapies; Acute exacerbations;
Roflumilast, type 4 phosphodiesterase inhibitor, attenuates inflammation in rats with ulcerative colitis via down-regulation of iNOS and elevation of cAMP
Keywords: روفلومیلاست; Roflumilast; Dextran sulfate sodium (DSS); TNF-α; MPO; iNOS;
Effect of adding roflumilast or ciclesonide to glycopyrronium on lung volumes and exercise tolerance in patients with severe COPD: A pilot study
Keywords: روفلومیلاست; COPD; Glycopyrronium; Roflumilast; Ciclesonide; Combination therapy; Exercise tolerance;
The mediating role of phosphodiesterase type 4 in the dopaminergic modulation of motor impulsivity
Keywords: روفلومیلاست; Dopamine; Roflumilast; Phosphodiesterase 4; cAMP; Impulsivity;
Roflumilast treatment inhibits lung carcinogenesis in benzo(a)pyrene-induced murine lung cancer model
Keywords: روفلومیلاست; Roflumilast; Lung cancer;
Identification, characterization and in silico ADMET prediction of Roflumilast degradation products
Keywords: روفلومیلاست; Roflumilast; Forced degradation; NMR spectroscopy; UFLC-QTOF; in silico ADMET; Degradation products;
The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses
Keywords: روفلومیلاست; PDE4; PDE4 inhibition; Roflumilast; Rolipram; Cognition; Memory; Emesis; cAMP
Simultaneous determination of roflumilast and its metabolite in human plasma by LC–MS/MS: Application for a pharmacokinetic study
Keywords: روفلومیلاست; Roflumilast; Roflumilast N-oxide; LC–MS/MS; Human plasma; Chinese healthy volunteers
Roflumilast combined with montelukast versus montelukast alone as add-on treatment in patients with moderate-to-severe asthma
Keywords: روفلومیلاست; Asthma; roflumilast; montelukast; phosphodiesterase 4 inhibitors; ACQ; Asthma Control Questionnaire; AE; Adverse event; ANCOVA; Analysis of covariance; ATS; American Thoracic Society; BMI; Body mass index; COPD; Chronic obstructive pulmonary disease; C-SS
PDE4 Inhibition as Potential Treatment of Epidermolysis Bullosa Acquisita
Keywords: روفلومیلاست; Akt; RAC-alpha serine/threonine-protein kinase; COL7; type VII collagen; EBA; epidermolysis bullosa acquisita; IC; immune complex; MAPK; mitogen-activated protein kinase; PD; pemphigoid disease; PDE4; phosphodiesterase-4; PMA; phorbol 12-myristate 13-acet
Roflumilast for asthma: Safety findings from a pooled analysis of ten clinical studies
Keywords: روفلومیلاست; Asthma; Placebo; Roflumilast; Safety
Roflumilast for asthma: Efficacy findings in mechanism of action studies
Keywords: روفلومیلاست; Allergen; Asthma; Eosinophil; FEV1; Roflumilast
Roflumilast for asthma: Efficacy findings in placebo-controlled studies
Keywords: روفلومیلاست; Asthma; Exacerbation; FEV1; Placebo; Roflumilast
Roflumilast for asthma: Efficacy findings in non-placebo-controlled comparator and dosing studies
Keywords: روفلومیلاست; Asthma; Beclomethasone; FEV1; Montelukast; Roflumilast
Research ReportPhosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system
Keywords: روفلومیلاست; Hypertension; Cognition; Rolipram; Roflumilast; pCREB; BDNF;
Pooled subpopulation analyses of the effects of roflumilast on exacerbations and lung function in COPD
Keywords: روفلومیلاست; Chronic obstructive pulmonary disease; Roflumilast; Inhaled corticosteroids; Long-acting β2-agonists; Exacerbation; Lung function;
Validated stability-indicating HPLC-DAD method for determination of the phosphodiesterase (PDE-4) inhibitor roflumilast
Keywords: روفلومیلاست; HPLC; Diode array detection; Roflumilast; Stability-indicating assay; Forced degradation
Roflumilast N-oxide inhibits bronchial epithelial to mesenchymal transition induced by cigarette smoke in smokers with COPD
Keywords: روفلومیلاست; Epithelial to mesenchymal transition; roflumilast; COPD;
A Year in Review: New Drugs for Older Adults in 2011
Keywords: روفلومیلاست; fidaxomicin; indacaterol; rivaroxaban; roflumilast;
Additive anti-inflammatory effects of beta 2 adrenoceptor agonists or glucocorticosteroid with roflumilast in human peripheral blood mononuclear cells
Keywords: روفلومیلاست; Roflumilast; cAMP; PDE4; Salmeterol; PBMC; DexamethasonePDE4i, phosphodiesterase 4 inhibitor; COPD, chronic obstructive pulmonary disease; LABA, long-acting β2 adrenoceptor agonist; PBMC, peripheral blood mononuclear cells; TNFα, tumor necrosis factor-α;
Sensitive quantification of roflumilast and roflumilast N-oxide in human plasma by LC–MS/MS employing parallel chromatography and electrospray ionisation
Keywords: روفلومیلاست; Daxas; Roflumilast; Parallel chromatography; Tandem mass spectrometry; ESI; LC–MS/MS
Roflumilast: A Phosphodiesterase-4 Inhibitor for the Treatment of Severe Chronic Obstructive Pulmonary Disease
Keywords: روفلومیلاست; chronic bronchitis; COPD; phosphodiesterase-4 inhibitors; roflumilast
A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma
Keywords: روفلومیلاست; Chronic guinea-pig asthma models; Remodelling; Airways hyperresponsiveness; Early and late asthmatic responses; Fluticasone propionate; Roflumilast; GW274150AHR, airway hyperresponsiveness; BAL, bronchoalveolar lavage; cAMP, cyclic adenosine monophosphate
Disease-modifying effect of ASP3258, a novel phosphodiesterase type 4 inhibitor, on subchronic cigarette smoke exposure-induced lung injury in guinea pigs
Keywords: روفلومیلاست; Phosphodiesterase 4; Chronic obstructive pulmonary disease; Cigarette smoke; Guinea pig; ASP3258; Roflumilast
PDE4-inhibitors: A novel, targeted therapy for obstructive airways disease
Keywords: روفلومیلاست; PDE4-inhibitor; Roflumilast; Clinical trials; Chronic obstructive airways disease
Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slices
Keywords: روفلومیلاست; Ciliary beat frequency; COPD; PDE4; Roflumilast
The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease
Keywords: روفلومیلاست; Roflumilast; Phosphodiesterase 4; COPD; Preclinical pharmacology; Oral therapy; Inflammation
PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways
Keywords: روفلومیلاست; Phosphodiesterase-4 (PDE4) inhibitor; Roflumilast; I/R; PKA; Epac; Nitric oxide (NO)
Effect of inhaled roflumilast on the prevention and resolution of allergen-induced late phase airflow obstruction in Brown Norway rats
Keywords: روفلومیلاست; Roflumilast; Inhaled; Lung function; Inflammation; Dry powder aerosol
Phosphodiesterase inhibitors in airways disease
Keywords: روفلومیلاست; Phosphodiesterase; Phosphodiesterase inhibitor; Asthma; Chronic obstructive pulmonary disease; Cilomilast; Roflumilast; Rolipram
Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions
Keywords: روفلومیلاست; Asthma; roflumilast; phosphodiesterase type 4; allergen provocation; inflammation; late phase; AHR; Airway hyperresponsiveness; AUC; Area under the curve; cAMP; Cyclic adenosine monophosphate; COPD; Chronic obstructive pulmonary disease; EAR; Early asthma