Keywords: RPA، پروتئین تکثیر A; Fork collapse; Replication checkpoint; ATR; Replisome; iPONDATR, ATM and Rad3-related; RPA, Replication protein A; iPOND, Isolation of proteins on nascent DNA; ChIP, Chromatin immunoprecipitation; HU, Hydroxyurea; ssDNA, Single-stranded DNA
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Functional roles of N-terminal and C-terminal domains in the overall activity of a novel single-stranded DNA binding protein of Deinococcus radiodurans
Keywords: RPA، پروتئین تکثیر A; Deinococcus radiodurans; Ssb protein; OB folds; EMSA; RecA; Strand exchange; Topoisomerase activityESDSA, extended synthesis-dependent strand annealing; OB fold, oligonucleotide/oligosaccharide binding fold; RPA, Replication protein A; Ssb, single-strande
Diffusion of Human Replication Protein A along Single-Stranded DNA
Keywords: RPA، پروتئین تکثیر A; RPA, replication protein A; ssDNA, single-stranded DNA; hRPA, human RPA; OB, oligonucleotide/oligosaccharide binding; smTIRF, single-molecule total internal reflectance fluorescence; dsDNA, double-stranded DNARPA; single-molecule fluorescence; dynamics; D
New insights into helitron transposable elements in the mesopolyploid species Brassica rapa
Keywords: RPA، پروتئین تکثیر A; TE, transposable element; RC, rolling circle; RPA, replication protein A; TSDs, target site duplications; TIRs, terminal inverted repeats; SSR, simple sequence repeat; psRNATarget, plant small RNA target analysis server; LTR, long terminal repeat; LINE, l
The complexity of DNA double strand breaks is a critical factor enhancing end-resection
Keywords: RPA، پروتئین تکثیر A; DSBs, DNA double strand breaks; IR, ionizing radiation; HR, homologous recombination; LET, linear energy transfer; RPA, replication protein A; PIKK, phosphatidyl inositol 3′ kinase-related kinase; MEF, mouse embryonic fibroblast; MMEJ, micro homology-medi
Targeting SMARCAL1 as a novel strategy for cancer therapy
Keywords: RPA، پروتئین تکثیر A; ATM, ataxia telangiectasia-mutated; ATR, Rad3 related kinase; ATRIP, ATR interacting protein; chk2, checkpoint kinase 2; DSB, dsDNA break; HARP, HepA-related protein; RPA, replication protein A; SIOD, Schimke immuno-osseous dysplasia; SMARCAL1, SWI/SNF-re
Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods
Keywords: RPA، پروتئین تکثیر A; Replication Protein A; Inhibitors; High-throughput screen; EMSA; DockingDNA, deoxyribonucleic acid; DDR, DNA damage response; BER, base excision repair; HRR, homologous recombination repair; SMI, small molecule inhibitor; RPA, Replication Protein A; kDa,
Phenylbutyrate inhibits homologous recombination induced by camptothecin and methyl methanesulfonate
Keywords: RPA، پروتئین تکثیر A; CPT, camptothecin; Top1, topoisomerase I; HDAC, histone deacetylase; PBA, sodium phenylbutyrate; HR, homologous recombination; RPA, replication protein A; HAT, histone acetyltransferase; YPD, yeast extract-peptone-dextrose; SC, synthetic complete; TSA, tr
Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding
Keywords: RPA، پروتئین تکثیر A; APE1, apurinic endonuclease 1; BER, base excision repair; BLM, Bloom syndrome protein; bp, base pair; FEN1, flap endonuclease 1; NER, nucleotide excision repair; nt, nucleotide; RPA, replication protein A; RTS, Rothmund–Thomson syndrome; SFII, superfamily
The Single-Stranded DNA Binding Protein of Sulfolobus solfataricus Acts in the Presynaptic Step of Homologous Recombination
Keywords: RPA، پروتئین تکثیر A; SSB, single-stranded DNA binding protein; ssDNA, single-stranded DNA; SsoSSB, Sulfolobus solfataricus SSB; SsoRadA, Sulfolobus solfataricus RadA; RPA, replication protein A; EcoSSB, Escherichia coli SSB; EMSA, electrophoretic mobility shift assay; EDTA, e
Molecular Analyses of an Unusual Translesion DNA Polymerase from Methanosarcina acetivorans C2A
Keywords: RPA، پروتئین تکثیر A; CPD, cis–syn cyclobutane pyrimidine thymine–thymine dimer; PCNA, proliferating cell nuclear antigen; Pol, DNA polymerase; PIP, PCNA-interacting protein; RFC, replication factor C; RPA, replication protein A; ssDNA, single-stranded DNA; TLS, translesion DN
A tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1
Keywords: RPA، پروتئین تکثیر A; DNA damage; Checkpoints; Cell cycle; Clamps; Clamp loaders; Protein kinaseATR, ataxia telangiectasia (ATM) related protein; BRCT, Brca1 C-terminus; RPA, replication protein A; ssDNA, single stranded DNA; PCNA, proliferating cell nuclear antigen; RFC, comp
Choreography of recombination proteins during the DNA damage response
Keywords: RPA، پروتئین تکثیر A; DSB, double-strand break; DSBR, double-strand break repair; HR, homologous recombination; IR, ionizing radiation; MMS, methyl methanesulfonate; NHEJ, non-homologous end-joining; RPA, replication protein A; GFP, green fluorescent protein; CFP, cyan fluores
Identification of the SSB Binding Site on E. coli RecQ Reveals a Conserved Surface for Binding SSB's C Terminus
Keywords: RPA، پروتئین تکثیر A; SSB, single-stranded DNA binding protein; RPA, replication protein A; OB, oligosaccharide binding; ssDNA, single-stranded DNA; RecQ-WH, RecQ winged-helix; HSQC, heteronuclear single quantum coherence; 3D, three-dimensional; NOESY, nuclear Overhauser enhan
Crosslinking of nucleotide excision repair proteins with DNA containing photoreactive damages
Keywords: RPA، پروتئین تکثیر A; NER, nucleotide excision repair; RPA, replication protein A; XPA, xeroderma pigmentosum group A protein; XPC, xeroderma pigmentosum group C protein; HR23B, homolog B of Rad23; FAP-dCTP, exo-N-{2-[N-(4-azido-2,5-difluoro-3-chloropyridine-6-yl)-3-aminopropi
DNA damage and homologous recombination signaling induced by thymidylate deprivation
Keywords: RPA، پروتئین تکثیر A; HR, homologous recombination; DSBs, DNA double strand breaks; TS, thymidylate synthase; RTX, raltitrexed (Tomudex™); BER, base excision repair; RPA, replication protein A; RPA2, 32-kDa subunit of replication protein A; γ-H2AX, phsophorylated histone prote
Ferroplasma acidarmanus RPA2 Facilitates Efficient Unwinding of Forked DNA Substrates by Monomers of FacXPD Helicase
Keywords: RPA، پروتئین تکثیر A; FacXPD, XPD from Ferroplasma acidarmanus; NER, nucleotide excision repair; RPA, replication protein A; ssDNA, single-stranded DNA; SF2, superfamily II; SF1, superfamily I; TFIIH, transcription factor IIH; dsDNA, double-stranded DNA; OB, oligonucleotide/ol
The role of WRN in DNA repair is affected by post-translational modifications
Keywords: RPA، پروتئین تکثیر A; WS, Werner syndrome; HGPS, Hutchinson-Gilford syndrome; BS, Bloom syndrome; RTS, Rothmund-Thomson syndrome; ssDNA, single stranded DNA; 4-NQO, 4-nitroquinoline-1-oxide; RPA, replication protein A; PCNA, proliferating cell nuclear antigen; CPT, camptotheci
RPA Mediates Recombination Repair During Replication Stress and Is Displaced from DNA by Checkpoint Signalling in Human Cells
Keywords: RPA، پروتئین تکثیر A; Chk1, checkpoint kinase 1; DSBs, DNA double-strand breaks; HU, hydroxyurea; MRN, MRE11/RAD50/NBS1; RPA, replication protein A; siRNA, small interfering RNA; TopBP1, topoisomerase IIβ binding protein 1RPA; homologous recombination; Chk1; mammalian cells; s
Mammalian TIMELESS and Tipin are Evolutionarily Conserved Replication Fork-associated Factors
Keywords: RPA، پروتئین تکثیر A; TIM, TIMELESS protein; Tipin, TIM interacting protein; RPA, replication protein A; ssDNA, single-strand DNA; ATR, ataxia-telangiectasia and Rad3-related; BrdU, 5′-bromo-2′-deoxyuridine; IP, immunoprecipitationTIMELESS; Tipin; DNA replication; checkpoint s
UV-induced RPA phosphorylation is increased in the absence of DNA polymerase η and requires DNA-PK
Keywords: RPA، پروتئین تکثیر A; ATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3-related; ATRIP, ATR-interacting protein; CPD, cyclobutane pyrimidine dimer; DNA-PK, DNA-dependent protein kinase; Polη, polymerase η; RPA, replication protein A; XPV, xeroderma pigmentosum variantPolη;