Keywords: RPE، اپیتلیوم رنگدانه شبکیه; AAV, adeno-associated virus; AAV2, adeno-associated viral vector serotype 2; AMD, age-related macular degeneration; iPSC, induced pluripotent stem cell; RP, retinitis pigmentosa; RPE, retinal pigment epithelium; VEGF, vascular endothelial growth factor
مقالات ISI RPE، اپیتلیوم رنگدانه شبکیه (ترجمه نشده)
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Keywords: RPE، اپیتلیوم رنگدانه شبکیه; CC3, complement component 3; AMD, age-related macular degeneration; OR, odds ratio; SNP, single nucleotide polymorphism; CI, confidence interval; RPE, retinal pigment epithelium; CNV, choroidal neovascularization; PB, population-based; HB, hospital-based;
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; CFC, cystoid fluid collections; DCMD, dominant cystoid macular dystrophy; EOG, electro-oculography; ERG, electroretinography; FA, fluorescein angiography; FAF, fundus autofluorescence; OCT, optical coherence tomography; RPE, retinal pigment epithelium; VA
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; AAV, adeno-associated virus; NP, nanoparticles; LCA, Leber’s congenital amaurosis; RPE, retinal pigment epithelium; OS, outer segment; SNP, single nucleotide polymorphism; ERG, electroretinogram; CME, clathrin mediated endocytosis; CvME, caveolae mediated
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; AMD, age-related macular degeneration; RPE, retinal pigment epithelium; nvAMD, neovascular age-related macular degeneration; VEGF, vascular endothelial growth factor; HtrA1, heat temperature required factor A; IL, interleukin; TNF, tumour necrosis factor;
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; Light-induced retinal damage; Beclin1; ATG7; Park2; All-trans-retinal; Visual cycleA2E, N-retinylidine-N-retinylethanolamine; ATG, autophagy-related gene; RAL, retinal; RPE, retinal pigment epithelium; ROL, retinol
Identification and validation of reference genes for quantitative RT-PCR analysis of retinal pigment epithelium cells under hypoxia and/or hyperglycemia
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; DR, diabetic retinopathy; RPE, retinal pigment epithelium; HIF-1α, hypoxia induced factor-1α; VEGF, vascular endothelial growth factor; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; Rn18s, 18S ribosomal RNA; ACTB, actin, beta; ALAS1, 5′-aminolevulinate
Validation of RT-qPCR reference genes and determination of Robo4 expression levels in human retinal endothelial cells under hypoxia and/or hyperglycemia
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; RT-qPCR, real-time reverse transcription quantitative polymerase chain reaction; HREC, human retinal endothelial cells; DR, diabetic retinopathy; Robo4, roundabout4; RPE, retinal pigment epithelium; PDR, proliferative diabetic retinopathy; 18S, 18S riboso
Cre recombinase expression or topical tamoxifen treatment do not affect retinal structure and function, neuronal vulnerability or glial reactivity in the mouse eye
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; Cre, Cre recombinase; FLA, fluorescein angiography; GFAP, glial fibrillary acidic marker protein; INL, inner nuclear layer; ONH, optic nerve head; ONL, outer nuclear layer; OS, ora serrata; PFA, paraformaldehyde; RPE, retinal pigment epithelium; TGF, tran
Opposite expression of CYP51A1 and its natural antisense transcript AluCYP51A1 in adenovirus type 37 infected retinal pigmented epithelial cells
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; HAdV-37, human adenovirus type 37; HAdV-5, human adenovirus type 5; CYP51A1, cytochrome P450, family 51, subfamily A, polypeptide 1; RPE, retinal pigment epithelium; RNAPII, RNA polymerase II; RNAPIII, RNA polymerase IIIAdenovirus; Human adenovirus type 3
Volume-Rendering Optical Coherence Tomography Angiography of Macular Telangiectasia Type 2
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; MacTel2, macular telangiectasia type 2; OCT, optical coherence tomography; OCTA, optical coherence tomography angiography; RPE, retinal pigment epithelium
The genetics of age-related macular degeneration (AMD) – Novel targets for designing treatment options?
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; Age-related macular degeneration (AMD); Geographic atrophy; Neovascular AMD; Genetic predisposition; Complement cascade; Therapeutic approaches; Clinical trialsAMD, age-related macular degeneration; RPE, retinal pigment epithelium; GA, geographic atrophy;
Variability of miRNA expression during the differentiation of human embryonic stem cells into retinal pigment epithelial cells
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; ESC, embryonic stem cell; hESC, human embryonic stem cell; RPE, retinal pigment epithelium; miRNA, microRNA; pri-miRNA, primary miRNA; pre-miRNA, miRNA precursor; isomiR, miRNA isoform; ADAR, adenosine deaminases-acting-on-RNA; A-to-I, adenosine-to-inosin
Light-induced disulfide dimerization of recoverin under ex vivo and in vivo conditions
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; AMD, age-related macular degeneration; rOx, reactive oxygen species; NO, nitric oxide; CH, choroid; RPE, retinal pigment epithelium; PL, photoreceptor layer; ONL, outer nuclear layer; INL, inner nuclear layer; GL, ganglion cell layer; NFL, nerve fiber lay
Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; DJ-1 knockout; Retina; Morphology; Physiology; Histology; Immunohistology; Biochemistry; OxidationPD, Parkinson's disease; KO, knockout; RPE, retinal pigment epithelium; NaIO3, sodium iodate; ROS, reactive oxygen species; AMD, age-related macular degenera
Elevated amyloid β production in senescent retinal pigment epithelium, a possible mechanism of subretinal deposition of amyloid β in age-related macular degeneration
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; Aβ, amyloid β; APP, amyloid precursor protein; RPE, retinal pigment epithelium; AMD, age-related macular degeneration; AD, Alzheimer’s disease; NEP, neprilysin; BACE, beta-site amyloid precursor protein cleaving enzymeAmyloid β; Retinal pigment epithelium
TNF-α promotes human retinal pigment epithelial (RPE) cell migration by inducing matrix metallopeptidase 9 (MMP-9) expression through activation of Akt/mTORC1 signaling
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; TNF-α, tumor necrosis factor-alpha; MMP-9, matrix metallopeptidase 9; PVR, proliferative vitreoretinopathy; RRD, rhegmatogenous retinal detachment; RPE, retinal pigment epithelium; ECM, extracellular matrix; mTOR, mammalian target of rapamycin; mTORC1, mT
Cholesterol enhances amyloid β deposition in mouse retina by modulating the activities of Aβ-regulating enzymes in retinal pigment epithelial cells
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; Aβ, amyloid β; APP, amyloid precursor protein; RPE, retinal pigment epithelium; AMD, age-related macular degeneration; AD, Alzheimer’s disease; NEP, neprilysinAmyloid β; Retinal pigment epithelium; Age-related macular degeneration; Cholesterol; Neprilysin
Tumor necrosis factor-alpha (TNF-α)-mediated in vitro human retinal pigment epithelial (RPE) cell migration mainly requires Akt/mTOR complex 1 (mTORC1), but not mTOR complex 2 (mTORC2) signaling
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; AICAR, 5-amino-1-β-d-ribofuranosyl-imidazole-4-carboxamide; AMPK, AMP activated protein kinase; PVR, proliferative vitreoretinopathy; TNF-α, tumor necrosis factor-alpha; RRD, rhegmatogenous retinal detachment; RPE, retinal pigment epithelium; ECM, extrace
Spatial and temporal expressions of prune reveal a role in Müller gliogenesis during Xenopus retinal development
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; CMZ, ciliary marginal zone; kDa, kilodalton; RPE, retinal pigment epithelium; OS, optic stalk; NR, neural retina; RGC, retinal ganglion cell; IPL, inner plexiform layer; MBS, mo
Dietary antioxidants prevent age-related retinal pigment epithelium actin damage and blindness in mice lacking αvβ5 integrin
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; AMD, age-related macular degeneration; CSB, cytoskeleton stabilization buffer; ERG, electroretinography; HNE, 4-hydroxynonenal; PFA, paraformaldehyde; POS, shed photoreceptor outer segment tips; RPE, retinal pigment epithelium; TLC, thin-layer chromatogra
24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; AMD, age-related macular degeneration; DHA, docosahexaenoic acid; RGC, retinal ganglion cells; RPE, retinal pigment epithelium; SLOS, Smith-Lemli-Opitz syndromeRetina; Cholesterol; Metabolism; Glaucoma; Neuron
Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; RPE, retinal pigment epithelium; SOPT, sodium-coupled oligopeptide transporter; deltorphin II, Tyr-D-Ala-Phe-Glu-Val-Val-Gly; DADLE, Tyr-D-Ala-Gly-Phe-D-LeuOligopeptide transporters; Hepcidin; Retinal pigment epithelium; Iron homeostasis; Ferroportin
Predicting visual outcomes for macular disease using optical coherence tomography
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; ETDRS, Early Treatment Diabetic Retinopathy Study; MPS, Macular Photocoagulation Study; AMD, age-related macular degeneration; OCT, optical coherence tomography; logMAR, logarithm of the minimum angle of resolution; RPE, retinal pigment epithelium; CNV, c
Retinol dehydrogenases (RDHs) in the visual cycle
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; retinol dehydrogenase; visual cycle; oxidation; reduction; retina; retinal pigment epitheliumRDH, retinol dehydrogenases; RPE, retinal pigment epithelium; OS, outer segment; SDR, short-chain dehydrogenase/reductase; IS, inner segment; Wt, wild-type
Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; Ad-RPE65, adenovirus expressing RPE65; LCA, Leber congenital amaurosis; MOI, multiplicity of infection; RPE, retinal pigment epithelium; CHX, cycloheximideRPE65; Visual cycle; Isomerohydrolase; Leber congenital amaurosis; Retinoids
Somatostatin analogues as therapeutics in retinal disease
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; ARMD, Age-related macular degeneration; bFGF, basic fibroblast growth factor; CME, cystoid macular edema; CNV, choroidal neovascularization; DR, diabetic retinopathy; GH, growth hormone; IGF, insulin growth factor; RPE, retinal pigment epithelium; SRIF, s
Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; ATRA, all-trans retinoic acid; MSRA, methionine sulfoxide reductase A (protein, gene, general); msrA, (refers to mRNA transcripts); RAR, retinoic acid receptor; RPE, retinal pigment epithelium; RXR, retinoid X-receptor; qRT-PCR, “real time” reverse transc
Effects of human Werner helicase on intrachromosomal homologous recombination mediated DNA deletions in mice
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; BSO, buthionine sulfoximine; BER, base excision repair; HR, homologous recombination; NHEJ, non-homologous end joining; 4-NQO, 4-nitroquinoline 1-oxide; RPE, retinal pigment epithelium; WS, Werner syndrome; GSH, reduced glutathione; MMS, methyl methane-su
Connexin 43 contributes to differentiation of retinal pigment epithelial cells via cyclic AMP signaling
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; RPE, retinal pigment epithelium; Cx, connexin; GJIC, gap-junctional intercellular communication; CNV, choroidal neovascularization; AMD, age-related macular degeneration; shRNA, short hairpin RNA; rCx43, rat connexin 43; bFGF, basic FGF; CRALBP, cellular
Secondary structure of a truncated form of lecithin retinol acyltransferase in solution and evidence for its binding and hydrolytic action in monolayers
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; LRAT, Lecithin retinol acyltransferase; VCD, vibrational circular dichroism; ECD, electronic circular dichroism; tLRAT, recombinant truncated form of LRAT; RPE, retinal pigment epithelium; OG, n-octyl-β-d-glucopyranoside; SDS, sodium dodecyl sulfate; BSA,
The locations of mitochondria in mammalian photoreceptors: Relation to retinal vasculature
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; OPL, outer plexiform layer; CO, cytochrome oxidase; OLM, outer limiting membrane; RPE, retinal pigment epithelium; ONL, outer nuclear layer; SD, Sprague–Dawley; BM, Bruch's membranePhotoreceptor stability; Mitochondria; Oxygen; Cytochrome oxidase
Modeling Smoking History: A Comparison of Different Approaches in the MARS Study on Age-Related Maculopathy
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; Age-Related Maculopathy; Age-Related Macular Degeneration; Smoking; Time Since Smoking Cessation; Smoking HistoryARM, age-related maculopathy; AMD, age-related macular degeneration; RPE, retinal pigment epithelium; MARS, Muensteraner Altern- und Retina-St
Impacts of two point mutations of RPE65 from Leber’s congenital amaurosis on the stability, subcellular localization and isomerohydrolase activity of RPE65
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; CHX, cycloheximide; LCA, Leber’s congenital amaurosis; LRAT, lecithin retinol acyltransferase; MOI, multiplicity of infection; RPE, retinal pigment epithelium; ER, endoplasmic reticulumLRAT; Retinoid; Retinal degeneration; RPE; RPE65; Visual cycle
Expression of JAM-A, AF-6, PAR-3 and PAR-6 during the assembly and remodeling of RPE tight junctions
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; RPE, retinal pigment epithelium; E3, embryonic day 3; CEF, chicken embryonic fibroblastsRetinal pigment epithelium; Blood–retinal barrier; Tight junction; Adherens junction; Cell culture
Coiled–coil targeting of myocilin to intracellular membranes
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; glaucoma; secretion; TIGR; trabecular meshwork; vesicleIOP, intraocular pressure; MYOC, myocilin; GFP, green fluorescent protein; CC, coiled-coil; OLF, olfactomedin; HtH, helix-turn-helix; GST, glutathione-S-transferase; RPE, retinal pigment epithelium
The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; retinal pigment epithelium; hypoxia; cell–cell adhesion; cell–matrix adhesionVEGF, vascular endothelial growth factor; PlGF, placental growth factor; VEGFR, VEGF receptor; HIF-1, hypoxia-inducible factor-1; RPE, retinal pigment epithelium; CNV, choroidal
Oxidative stress in ARPE-19 cultures: Do melanosomes confer cytoprotection?
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; RPE, retinal pigment epithelium; tBH, tert-butyl hydroperoxide; MEM, minimum essential medium; PBS, phosphate-buffered saline; DHE, dihydroethidium; ROS, reactive oxygen species; DMSO, dimethyl sulfoxide; PI, propidium iodide; MTT, 3-[4,5-dimethylthiazol-
On the mechanism of isomerization of all-trans-retinol esters to 11-cis-retinol in retinal pigment epithelial cells: 11-Fluoro-all-trans-retinol as substrate/inhibitor in the visual cycle
Keywords: RPE، اپیتلیوم رنگدانه شبکیه; tROL, all-trans-retinol; 11-F-tROL, 11-fluoro-all-trans-retinol; tREs, all-trans-retinyl esters; LRAT, lecithin retinol acyl transferase; IMH, isomerohydrolase; RPE, retinal pigment epithelium; CRALBP, cellular retinaldehyde binding protein; BSA, bovine s