Viscous Drag as the Source of Active Site Perturbation during Protease Translocation: Insights into how Inhibitory Processes are Controlled by Serpin Metastability
Keywords: kinetic folding trap; metastability; α1-antitrypsin; acyl-linkage hydrolysis; conformational changeserpin, serine protease inhibitor; α1AT, α1-antitrypsin; RSL, reactive site loop; SI, stoichiometry of inhibition; PPE, porcine pancreatic elastase; HLE, hu