Myopathy-causing Q147P TPM2 mutation shifts tropomyosin strands further towards the open position and increases the proportion of strong-binding cross-bridges during the ATPase cycle
Keywords: TM, Tropomyosin; WT, Wild-type; S1, Myosin subfragment-1; FITC-phalloidin, Phalloidin-fluorescein isothiocyanate; 1,5-IAEDANS, N-(iodoacetaminoethyl)-1-naphthyl-amine-5-sulfonic acid; 5-IAF, 5-iodoacetamidofluorescein; SDS − PAGE, Polyacrylamide gel elect