Impaired IL-7 signaling may explain a case of atypical JAK3-SCID
Keywords: JAK3; SCID; Cytokine receptors; Signal transduction; γc;
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Mental disorders among acute burn patients
Keywords: Burns; SCID; Mental disorders
Research ArticleFactors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice
Keywords: Hepatocyte transplantation; Human hepatocyte; Mouse hepatocyte; Repopulation; uPA-SCID mouse; HCV; HBV; Viral kinetics; Liver necrosis; uPA; urokinase-type plasminogen activator; SCID; severe combined immune deficient; HBV; hepatitis B virus; HCV; hepatit
Neurocognitive Function of Patients with Severe Combined Immunodeficiency
Keywords: SCID; Neurocognitive function; Late effects;
Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia
Keywords: Angiotensin II type1 receptor blocker; Ischemia/reperfusion cerebral injury; Neuroprotection; PPARγ agonist activity; Anti-inflammation; AT1; angiotensin II type1; ARB; AT1 receptor blockers; RAS; rennin-angiotensin system; PPARγ; peroxisome prolifera
Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation
Keywords: Humanized mice; SCID; Hematopoietic stem cells; IL-2R “common” gamma chain;
Engineering proteolytically-degradable artificial extracellular matrices
Keywords: ECM mimics; ECM analogs; Protease sensitive; Cell responsive; Proteolytic degradation; Enzymatic cleavage; 2D; Two-dimensional; 3D; Three-dimensional; A; Alanine; AAc; Acrylic acid; ADAM-TS; ADAMs with thrombospondin motifs; ADAMs; Metalloprotease-disinte
Advances in basic and clinical immunology in 2008
Keywords: Basic immunology; antigen presentation; regulatory T cells; clinical immunology; primary immunodeficiency; hereditary angioedema; hematopoietic stem cell transplantation; partial DiGeorge syndrome; HIV infection; ACE; Angiotensin-converting enzyme; ADA; A
Characteristics of Hemophagocytic Lymphohistiocytosis in Neonates: A Nationwide Survey in Japan
Keywords: β2-MG; beta-2-microglobulin; CSF; Cerebrospinal fluid; HLH; Hemophagocytic lymphohistiocytosis; HSV; Herpes simplex virus; LDH; Lactate dehydrogenase; SCID; Severe combined immunodeficiency; sIL-2R; Soluble interleukin-2 receptor;
The modified SCID Hypomania Module (SCID-Hba): A detailed systematic phenomenologic probing
Keywords: SCID; Hypomania; Diagnosis; Interview
Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a coronin-1A mutation and a chromosome 16p11.2 deletion
Keywords: SCID; Coronin-1A; Actin cytoskeleton; Chromosome 16p11.2; Autism spectrum; Attention deficit and hyperactivity
A histidine in the β-CASP domain of Artemis is critical for its full in vitro and in vivo functions
Keywords: Artemis; HCA; Metallo-β-lactamase; NHEJ; SCID;
Reduced central tolerance in Omenn syndrome leads to immature self-reactive oligoclonal T cells
Keywords: Omenn syndrome; autoimmunity; immunodeficiency; SCID; AIRE; tolerance; Foxp3; Treg; oligoclones; TRECAIRE, Autoimmune regulator; DN, Double-negative; DP, Double-positive; Foxp3, Forkhead box P3; NKT, Natural killer T; OS, Omenn syndrome; RAG, Recombinase-
Long-term Clinical Outcome of Patients with Severe Combined Immunodeficiency Who Received Related Donor Bone Marrow Transplants without Pretransplant Chemotherapy or Post-transplant GVHD Prophylaxis
Keywords: ADA; Adenosine-deaminase; ADHA; Attention deficit hyperactivity disorder; GVHD; Graft verus host disease; HPV; Human papilloma virus; SCID; Severe combined immunodeficiency;
Who is at risk for ongoing dizziness and psychological strain after a vestibular disorder?
Keywords: vertigo; vestibular disorders; emotional distress; anxiety; depression; BPPV; benign paroxysmal positioning vertigo; GSI; global severity index; MD; Menière's disease; SCID; structural clinical interview for DSM-IV; SCL-90R; symptom checklist 90R; SD; st
Relative CD4 lymphopenia and a skewed memory phenotype are the main immunologic abnormalities in a child with Omenn syndrome due to homozygous RAG1-C2633T hypomorphic mutation
Keywords: SCID; RAG; Omen syndrome; Hypomorphic mutation; Memory T cells
Peptides Derived from Type IV Collagen, CXC Chemokines, and Thrombospondin-1 Domain-Containing Proteins Inhibit Neovascularization and Suppress Tumor Growth in MDA-MB-231 Breast Cancer Xenografts
Keywords: HUVECs; human umbilical vein endothelial cells; SCID; severe combined immunodeficient; TSP-1; thrombospondin-1; VEGF; vascular endothelial growth factor;
Accessibility of chromosomal recombination breaks in nuclei of wild-type and DNA-PKcs-deficient cells
Keywords: DNA-PKcs; RAG1; RAG2; Scid; V(D)J recombination;
Immunologic and clinical features of 25 Amish patients with RMRP 70 A → G cartilage hair hypoplasia
Keywords: Cartilage-hair hypoplasia; Severe combined immunodeficiency; SCID; Primary immunodeficiency; Autoimmune hemolytic anemia; Juvenile rheumatoid arthritis; RMRP
Patterns and Predictors of Trajectories of Depression after an Urban Disaster
Keywords: Depression; Mental Disorders; Disasters; BSI; Brief Symptom Inventory; DSM-IV; Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition; NYC; New York City; SCID; Structured Clinical Interview for Diagnostic and Statistical Manual of Mental D
Hypoxia and the metabolic phenotype of prostate cancer cells
Keywords: ALDO; aldolase; CS; citrate synthase; COX; cytochrome c oxidase; DCA; dichloroacetate; G3PDH; glyceraldehyde-3-phosphate dehydrogenase; G6PDH; glucose-6-phosphate dehydrogenase; HK; hexokinase; HIF; hypoxia-inducible factor; LDH; lactate dehydrogenase; NR
Validation of the Leverton Questionnaire as a screening tool for postnatal depression in Hungary
Keywords: Leverton Questionnaire; Validation; Postnatal depression; Beck Depression Inventory; SCID
Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity
Keywords: Zebrafish; Mouse; rag1; Innate immunity; SCID;
ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia
Keywords: ORAI1; STIM1; CRAC; calcium channel; Ca2+; store-operated Ca2+ entry; T cells; immunodeficiency; signal transduction; congenital myopathy; anhydrotic ectodermal dysplasia; dental enamel; amelogenesis imperfecta; CRAC; Ca2+ release activated Ca2+; EDA; Ect
Improving cellular therapy for primary immune deficiency diseases: Recognition, diagnosis, and management
Keywords: Allogeneic hematopoietic stem cell transplantation; gene therapy; primary immunodeficiency; clinical trial; ADA; Adenosine deaminase; ALC; Absolute lymphocyte count; CGD; Chronic granulomatous disease; CIBMTR; Center for International Blood and Marrow Tr
Tissue-specific DNA-PK-dependent H2AX phosphorylation and γ-H2AX elimination after X-irradiation in vivo
Keywords: DSB, DNA double-strand break; ECL, enhanced chemiluminescence; γ-H2AX, phosphorylated H2AXATM; DNA-PKcs; Histone H2AX phosphorylation; Ionizing radiation; SCID
Hippocampus and amygdalar volumes in patients with refractory obsessive-compulsive disorder
Keywords: MRI; magnetic resonance imaging; OCD; obsessive-compulsive disorder; SCID; Structured Clinical Interview for the Diagnostic Schedule for Mental Disorders; Y-BOCS; Yale-Brown Obsessive-Compulsive Scale; ANCOVA; analyses of covariance.; MRI; Hippocamp
Memory impairment correlates with increased S100B serum concentrations in patients with chronic schizophrenia
Keywords: AVLT; Auditory Verbal Learning Test; CPZ; chlorpromazine; CSF; cerebrospinal fluid; DCS; Diagnostic Test of Cerebral Dysfunction; H; high S100B serum level; L; low S100B serum level; PANSS; Positive and Negative Syndrome Scale; rhEPO; recombinant human er
Effect of CAG repeat length on psychiatric disorders in Huntington’s disease
Keywords: Huntington disease; Genetics; CAG repeats; Psychiatric disorders; SCID; Neuropsychiatry
Cigarette Smoking Associated with Attention Deficit Hyperactivity Disorder
Keywords: ADHD; Attention deficit hyperactivity disorder; CD; Conduct disorder; DSM; Diagnostic and Statistical Manual of Mental Disorders; FTQ; Fagerström Tolerance Questionnaire; K-SADS-E; Schedule for Affective Disorders and Schizophrenia for School-Aged Childr
Associations between increases in plasma n-3 polyunsaturated fatty acids following supplementation and decreases in anger and anxiety in substance abusers
Keywords: AA; arachidonic acid; ALA; alpha-linolenic acid; ASI; Addiction Severity Index questionnaire; DHA; docosahexaenoic acid; DPA; docosapentaenoic acid; EPA; eicosapentaenoic acid; 5-HIAA; 5-Hydroxyindole Acetic Acid; 5-HT; serotonin; FA; fatty acid; LA; lino
Megadose CD34+ Cell Grafts Improve Recovery of T Cell Engraftment but not B Cell Immunity in Patients with Severe Combined Immunodeficiency Disease Undergoing Haplocompatible Nonmyeloablative Transplantation
Keywords: SCID; Haplocompatible; CD34 selection; T cell depletion
Evaluation of the tolerogenic effects of donor bone marrow cells using a severe combined immunodeficient mouse-human islet transplant model
Keywords: SCID; Human islet model; Bone marrow; Transplantation; Tolerance;
Th2 Cytokine-Induced Alterations in Intestinal Smooth Muscle Function Depend on Alternatively Activated Macrophages
Keywords: 5-HT; 5-hydroxytryptamine; AAMÏ; alternatively activated macrophage; BEC; S-(2-boronoethyl)-I-cysteine; CAMÏ; classically activated macrophage; Cl2MDP; clodronate; FIZZ; found in inflammatory zone; IFN-γ; interferon-γ; IGF-1; insulin-like growth facto
Constitutive CXCL12 Expression Induces Anoikis in Colorectal Carcinoma Cells
Keywords: ECM; extracellular matrix; eGFP; enhanced green fluorescent protein; ERK1/2; extracellular-regulated kinase-1/2; FAK; focal adhesion kinase; MEK1; mitogen-activated protein kinase kinase 1; poly-HEMA; polyhydroxyethylmethacrylate; SCID; severe combined im
Molecular mechanisms of mistletoe plant extract-induced apoptosis in acute lymphoblastic leukemia in vivo and in vitro
Keywords: Mistletoe; ALL; Leukemia; Apoptosis; SCID; NALM-6; Helixor; Alternative; Phytotherapy
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene
Keywords: NOD-scid; IL-2r gamma chain; Humanized mice; SCID; Transplantation; Islet; Rejection; Hu-PBL-SCID; Human; Mouse
Protective role of nuclear factor of activated T cells 2 in CD8+ long-lived memory T cells in an allergy model
Keywords: NFATc2; CD8+ T cells; IL-2; IL-10; IFN-γ; IL-17; long-lived memory cells; CD8+CD122+(IL-2Rβ)+CD127(IL-7Rα)+ T cells; allergy; model of human allergic asthma; AHR; Airway hyperresponsiveness; BALF; Bronchoalveolar lavage fluid; FACS; Fluorescence-activ
Failure of low-dose recombinant human IL-2 to support the survival of virus-specific CTL clones infused into severe combined immunodeficient foals: Lack of correlation between in vitro activity and in vivo efficacy
Keywords: EIAV; Horse; SCID; CTL; Adoptive transfer; IL-2
Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol
Keywords: CSF; Cerebrospinal fluid; H-MRS; High-resolution magnetic resonance spectroscopy; PANSS; Positive and negative symptom s.cale; SCID; Structured clinical interview for DSM-IV; SD; Standard deviation; Glia; MR-spectroscopy; Myo-inositol; S100B protein; Schi
Emergence and persistence of multiple antiviral-resistant CMV strains in a highly immunocompromised child
Keywords: Cytomegalovirus; Antiviral resistance; SCID
Higher Levels of Extroverted Hostility Detected in Gene Carriers at Risk for Huntington’s Disease
Keywords: CAG repeats; genetics; hostility; Huntington disease; psychiatric disorders; SCID
IL-7 receptor deficient SCID with a unique intronic mutation and post-transplant autoimmunity due to chronic GVHD
Keywords: Severe combined immunodeficiency; SCID; Myasthenia gravis; Myositis; Hematopoietic stem cell transplantation; HSCT; Interleukin-7 receptor; Human mutation; Intronic mutation; Mechanisms of mutation
Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model
Keywords: Pancreatic cancer; Thrombospondin-1; Angiogenesis; Anti-angiogenic therapy; Continuous administration; Orthotopic model; 3TSR; three thrombospondin-1 type 1 repeats; BSA; bovine serum albumin; HDMEC; human dermal microvessel endothelial cell; MVD; microve
Strength and corticosteroid responsiveness of mdx mice is unchanged by RAG2 gene knockout
Keywords: BW; body weight; CK; creatine kinase; FGS; forelimb grip strength; GC; glucocorticoid; RAG2; recombinase activating gene 2; SCID; severe combined immune deficiency; mdx mouse; Prednisolone; RAG2 knockout; Strength; Fatigue; Voluntary wheel running; T-cell
Classical complement activation and acquired immune response pathways are not essential for retinal degeneration in the rd1 mouse
Keywords: retinal degeneration; immune response; rd1; SCID; Rag1−/−; complement system
Existence of a threshold-like dose for γ-ray induction of thymic lymphomas and no susceptibility to radiation-induced solid tumors in SCID mice
Keywords: SCID, severe combined immune deficiency; DNA-PK, DNA-dependent protein kinase; DNA-PKcs, DNA-dependent protein kinase catalytic subunitRadiation-induced carcinogenesis; Thymic lymphoma; SCID;
Development of a model system for preliminary evaluation of tissue-engineered vascular conduits
Keywords: Tissue engineering; Vascular conduit; SCID; Mice; Decellularized; Ovine
The last 80 years in primary immunodeficiency: How far have we come, how far need we go?
Keywords: Primary immunodeficiency; history and future prospects; molecular defects; intravenous immunoglobulin treatment; bone marrow stem cell transplantation; gene therapy; CVID; Common variable immunodeficiency; HAART; Highly active antiretroviral therapy; IVIG
Novel mutations in the respiratory syncytial virus G gene identified in viral isolates from a girl with severe combined immune deficiency treated with intravenous immune globulin
Keywords: RSV, respiratory syncytial virus; IVIG, intravenous immunoglobulin; SCID, severe combined immune deficiency; PICU, pediatric intensive care unit; DFA, direct immunofluorescence assayRespiratory syncytial virus; IVIG; SCID; G glycoprotein mutations; Premat