Keywords: SH2، Src همولوژی 2; RNase A, ribonuclease A; Itk, interleukin-2 tyrosine kinase; SH2, Src homology 2; G3P, gene 3 protein; EF-G, elongation factor G; CypA, cyclophilin A; FKBP, FK506 binding protein; TF, trigger factorprotein folding; protein regulation; prolyl isomerases; c
مقالات ISI SH2، Src همولوژی 2 (ترجمه نشده)
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Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm
Keywords: SH2، Src همولوژی 2; KSR, kinase suppressor of Ras; ERK, extracellular signal-regulated protein kinase; T-KSR2, testes-kinase suppressor of Ras 2; MAPK, mitogen activated protein kinase; CA, conserved area; SH2, Src homology 2; RACE, rapid amplification of cDNA ends; NDK-1, n
Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene
Keywords: SH2، Src همولوژی 2; Cten, C-terminal tensin-like; SH2, Src homology 2; PTB, phosphotyrosine-binding; Q-PCR, quantitative-PCR; 5′RAC, 5′-Rapid amplification of cDNA ends; CDS, coding regions; MSA, multiple sequence alignment (MSA); BPH, benign prostatic hyperplasia (BPH); ENC
Genetic Incorporation of a Photo-Crosslinkable Amino Acid Reveals Novel Protein Complexes with GRB2 in Mammalian Cells
Keywords: SH2، Src همولوژی 2; SH2, Src homology 2; pBpa, p-benzoyl-l-phenylalanine; EGFR, epidermal growth factor receptor; SH3, Src homology 3; pTyr, phosphorylated tyrosine; EGF, epidermal growth factor; tmdPhe, p-trifluoromethyl-diazirinyl-l-phenylalanine; TyrRS, tyrosyl-tRNA synth
Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain
Keywords: SH2، Src همولوژی 2; APP, amyloid precursor protein; AICD, APP intracellular C-terminal domain; AD, Alzheimer's disease; SH2, Src homology 2; Grb2, growth factor receptor binding protein-2; PTB, protein tyrosine binding; PDB, Protein Data Bank; CFP, cyan fluorescent protein;
Mutation of tyrosine residue 857 in the PDGF β-receptor affects cell proliferation but not migration
Keywords: SH2، Src همولوژی 2; PDGF, platelet-derived growth factor; PDGFR, PDGF receptor; Erk, extracellular regulated kinase; PAE, porcine aortic endothelial cell; PI3K, phosphatidylinositol 3-kinase; FBS, fetal bovine serum; SH2, Src homology 2; SHP-2, SH2-domain containing phosphat
What precedes the initial tyrosine phosphorylation of the high affinity IgE receptor in antigen-activated mast cell?
Keywords: SH2، Src همولوژی 2; FcεRI, high-affinity IgE receptor; MIRR, multichain immune recognition receptor; ITAM, immunoreceptor tyrosine-based activation motif; SH2, Src homology 2; PTK, protein tyrosine kinase; PTP, protein tyrosine phosphatase; RBL, rat basophilic leukemia; EGFP
Identification of an Allosteric Signaling Network within Tec Family Kinases
Keywords: SH2، Src همولوژی 2; Itk, interleukin-2 tyrosine kinase; Btk, Bruton's tyrosine kinase; SH2, Src homology 2; SH3, Src homology 3; PKA, protein kinase A; PDB, Protein Data BankItk and Btk; regulatory spine; kinase activation; gatekeeper residue; phosphorylation
Activated Rac1 requires gp130 for Stat3 activation, cell proliferation and migration
Keywords: SH2، Src همولوژی 2; STATs, Signal Transducers and Activators of Transcription; IL6, Interleukin-6; ptyr, phosphorylated tyrosine; Erk, Extracellular-signal activated kinase; SH2, Src homology 2; JAKs, Janus kinases; Hsp90, Heat shock protein 90; NFkB, Nuclear Factor-kappaB;
Functional Interaction of the Ras Effector RASSF5 with the Tyrosine Kinase Lck: Critical Role in Nucleocytoplasmic Transport and Cell Cycle Regulation
Keywords: SH2، Src همولوژی 2; NES, nuclear export signal; SH3, Src homology 3; NLS, nuclear localization signal; LMB, leptomycin B; SH2, Src homology 2; NPC, nuclear pore complex; CHX, cycloheximide; GFP, green fluorescent protein; GST, glutathione S-transferase; DMEM, Dulbecco's modi
Csk-binding protein can regulate Lyn signals controlling cell morphology
Keywords: SH2، Src همولوژی 2; Csk, COOH-terminal Src kinase; Cbp, Csk binding protein; SH2, Src homology 2; SH3, Src homology 3; Epo, erythropoietin; SOCS1, suppressor of cytokine signaling 1; STAT, signal transducer and activator of transcription; JAK, Janus kinase; PLCγ, phspholipas
SH2-Dependent Autophosphorylation within the Tec Family Kinase Itk
Keywords: SH2، Src همولوژی 2; Itk, interleukin-2 tyrosine kinase; Btk, Bruton's tyrosine kinase; SH2, Src homology 2; SH3, Src homology 3; XLA, X-linked agammaglobulinemia; Csk, C-terminal Src kinase; Irk, insulin receptor kinase; PI3K, phosphoinositide 3-kinase; HSQC, heteronuclear s
Proline Isomerization Preorganizes the Itk SH2 Domain for Binding to the Itk SH3 Domain
Keywords: SH2، Src همولوژی 2; Itk, interleukin-2 tyrosine kinase; SH3, Src homology 3; SH2, Src homology 2; PH, Pleckstrin homology; pY, phosphotyrosine; RDC, residual dipolar coupling; NOE, nuclear Overhauser enhancement; NOESY, NOE spectroscopy; 3D, three-dimensional; TOCSY, total c
Tyk2 expression and its signaling enhances the invasiveness of prostate cancer cells
Keywords: SH2، Src همولوژی 2; Jak, Janus kinase; RT-PCR, reverse transcriptase-polymerase chain reaction; SH2, Src homology 2; Stat, signal transducers and activators of transcriptionTyk2; Jak; Prostate cancer; Invasion; Metastasis
The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels
Keywords: SH2، Src همولوژی 2; SOCS, suppressors of cytokine signaling; STAT, signal transducer and activator of transcription; JAK, Janus kinase; SH2, Src homology 2; CIS, cytokine-inducible SH2-containing protein; IR, insulin receptor; IRS, insulin receptor substrate; GFP, green fluo
Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcδ activation
Keywords: SH2، Src همولوژی 2; PMA, phorbol 12-myristate 13-acetate; SOCS, suppressors of cytokine signaling; STAT, signal transducer and activator of transcription; JAK, Janus kinase; SH2, Src homology 2; CIS, cytokine-inducible SH2-containing protein; PKC, protein kinase CPMA; SOCS6;
High resolution crystal structures of the p120 RasGAP SH3 domain
Keywords: SH2، Src همولوژی 2; SH3, Src homology 3; SH2, Src homology 2; RasGAP, Ras GTPase activating protein; G3BP, RasGAP SH3 binding protein; p190, Rho GTPase activating protein; PH, pleckstrin homology; SAD, Single-wavelength anomalous diffractionRasGAP; SH3 domain; Dimerization;
Localized activation of Src-family protein kinases in the mouse egg
Keywords: SH2، Src همولوژی 2; MII, meiosis II; GST, glutathione S transferase; SH2, Src homology 2; eCG, equine chorionic gonadotropin; hCG, human chorionic gonadotropin; KSOM, potassium simplex optimized medium; PIPES, piperazine-N,N′-bis[2-ethanesulfonic acid]; EGTA, ethylene glycol
Crystal structure of the C-terminal SH3 domain of the adaptor protein GADS in complex with SLP-76 motif peptide reveals a unique SH3–SH3 interaction
Keywords: SH2، Src همولوژی 2; SH3, Src homology 3; SH2, Src homology 2; LAT, linker for activation of T cell; r.m.s.d., root-mean-square difference; PRS, prolin-rich sequencesGADS; SLP-76; SH3; SH3–SH3 interaction; Signaling transduction; X-ray crystallography
Solution Structure of a Hck SH3 Domain Ligand Complex Reveals Novel Interaction Modes
Keywords: SH2، Src همولوژی 2; Hck, hematopoietic cell kinase; SH3, Src homology 3; SH2, Src homology 2; HckSH3, Hck SH3 domain; Fyn, Fgr/Yes-related kinase; Abl, Abelson tyrosine kinase; Src, Rous sarcoma viral oncogene homolog; Nef, negative factor; ADAM, a disintegrin and metallopro
Two dimensional Blue Native-/SDS-PAGE analysis of SLP family adaptor protein complexes
Keywords: SH2، Src همولوژی 2; BCR, B cell antigen receptor; BN-PAGE, Blue Native polyacrylamide gel electrophoresis; 2D, two dimensional; Gads, Grb2-like adaptor protein downstream of Shc; MPC, multiprotein complex; SH2, Src homology 2; SH3, src homology 3; SLP, SH2 domain containing
Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130
Keywords: SH2، Src همولوژی 2; aa, amino acid; ELISA, enzyme-linked immunosorbant assay; FERM, four-point-one, ezrin, radixin, moesin; JAK, Janus kinase; R, receptor; SH2, Src homology 2; SHP2, SH2-domain-containing tyrosine phosphatase 2; SOCS, suppressor of cytokine signalling; STAT,
Regulation of Stat3 nuclear import by importin α5 and importin α7 via two different functional sequence elements
Keywords: SH2، Src همولوژی 2; STAT, Signal Transducers and Activators of Transcription; IP, immunoprecipitation; JAK, Janus kinase; SH2, Src homology 2; PCR, polymerase chain reaction; PBS, phosphate-buffered saline; TCL, total cell lysate; GST, Glutathione-S-transferase; SDS-PAGE, SD