Regions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligands
Keywords: دامنه های SH3; DLS; dynamic light scattering; ITC; isothermal titration calorimetry; PRR; proline rich region; TIRF; total internal reflection fluorescence; SH3 domains; GRB2; SOS1; CBL; Signal transduction;